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- W2953807663 endingPage "2348" @default.
- W2953807663 startingPage "2335" @default.
- W2953807663 abstract "Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to shrink tumors. Crucial for apoptotic function are executioner caspases, most notably caspase-3, that proteolyze a variety of proteins, inducing cell death. Paradoxically, overexpression of procaspase-3 (PC-3), the low-activity zymogen precursor to caspase-3, has been reported in a variety of cancer types. Until recently, this counterintuitive overexpression of a pro-apoptotic protein in cancer has been puzzling. Recent studies suggest subapoptotic caspase-3 activity may promote oncogenic transformation, a possible explanation for the enigmatic overexpression of PC-3. Herein, the overexpression of PC-3 in cancer and its mechanistic basis is reviewed; collectively, the data suggest the potential for exploitation of PC-3 overexpression with PC-3 activators as a targeted anticancer strategy." @default.
- W2953807663 created "2019-07-12" @default.
- W2953807663 creator A5004996669 @default.
- W2953807663 creator A5027996458 @default.
- W2953807663 creator A5038891328 @default.
- W2953807663 date "2019-07-01" @default.
- W2953807663 modified "2023-10-12" @default.
- W2953807663 title "Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential" @default.
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