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- W2953814733 abstract "Genomic instability emerges due to accumulation of mutations in the genome, preventing the normal structure and function of the chromosomes. This genomic instability may arise from hereditary mutations or may be associated with DNA damage caused either by endogenous (e.g. replication problems) or exogenous (e.g. radiation) agents. To counter this, cells have evolved various strategies that aim at detecting and repairing DNA damage or at eliminating cells with overt damage. When these strategies fail genomic instability prevails and underlies the hallmark that are key for cancer development." @default.
- W2953814733 created "2019-07-12" @default.
- W2953814733 creator A5002878895 @default.
- W2953814733 date "2019-01-01" @default.
- W2953814733 modified "2023-09-25" @default.
- W2953814733 title "Genomic Instability: DNA Repair and Cancer" @default.
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- W2953814733 doi "https://doi.org/10.1007/978-3-030-11812-9_5" @default.
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