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- W2953830193 abstract "Converging evidence supports neuroimmune factors in depression psychopathology. We previously reported reduced depression-like behavior in immunomodulatory G-protein-coupled receptor, T cell death-associated gene-8 (TDAG8) deficient mice. Here, we expand on those findings by investigating depression- and anxiety-associated behaviors, and cytokine profiles in TDAG8-deficient mice. TDAG8-deficiency reduced depression- and anxiety-associated behaviors in the forced swim test (FST), open-field test and elevated zero maze. Interestingly, cytokine expression, particularly IL-6, was attenuated within hippocampus and spleen in TDAG8-deficient mice following the FST. There were no differences in immune-cell frequencies. Collectively, these data suggest a contributory role of TDAG8 in neuroimmune regulation and depression-associated physiology." @default.
- W2953830193 created "2019-07-12" @default.
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- W2953830193 date "2019-10-01" @default.
- W2953830193 modified "2023-10-16" @default.
- W2953830193 title "Immunomodulatory T cell death associated gene-8 (TDAG8) receptor in depression-associated behaviors" @default.
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- W2953830193 doi "https://doi.org/10.1016/j.physbeh.2019.112598" @default.
- W2953830193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6701469" @default.
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- W2953830193 hasPublicationYear "2019" @default.
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