Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953850501> ?p ?o ?g. }
- W2953850501 endingPage "1739" @default.
- W2953850501 startingPage "1729" @default.
- W2953850501 abstract "Background: Many of the activities associated with pepper fruits have been attributed to piperine, the most active compound present in these spices. Objective: This paper aims to provide an overview of the known properties of piperine, i.e. piperine’s chemistry, its physiological activity, documented interactions as a bioenhancer and reported data concerning its toxicity, antioxidant properties and anticancer activity. Discussion: It is known that piperine possesses several properties. In its interaction with other drugs, it can act as a bioavailability enhancer; this effect is also manifested in combination with other nutraceuticals, e.g. with curcumin, i.e. piperine can modify curcumin’s antioxidant, anti-inflammatory, antimicrobial and anticancer effects. Piperine displays significant immunomodulating, antioxidant, chemopreventive and anticancer activity; these effects have been shown to be dose-dependent and tissue-specific. However, the main limitation associated with piperine seems to be its low bioavailability, a disadvantage that innovative formulations are overcoming. Conclusion: It is predicted that an increasing number of studies will focus on piperine, especially those directed towards unraveling its properties at molecular level. The current knowledge about the action of piperine will form a foundation for ways to improve piperine’s bioavailability e.g. exploitation of different carrier systems. The therapeutical applications of this compound will be clarified, and piperine will be recognized as an important nutraceutical." @default.
- W2953850501 created "2019-07-12" @default.
- W2953850501 creator A5021876651 @default.
- W2953850501 creator A5026101028 @default.
- W2953850501 creator A5028187109 @default.
- W2953850501 creator A5070969081 @default.
- W2953850501 creator A5083382151 @default.
- W2953850501 creator A5088767852 @default.
- W2953850501 date "2019-08-19" @default.
- W2953850501 modified "2023-10-16" @default.
- W2953850501 title "Piperine: Old Spice and New Nutraceutical?" @default.
- W2953850501 cites W1217743210 @default.
- W2953850501 cites W1276566291 @default.
- W2953850501 cites W1487719749 @default.
- W2953850501 cites W1488734028 @default.
- W2953850501 cites W1548944035 @default.
- W2953850501 cites W1690222005 @default.
- W2953850501 cites W1845711954 @default.
- W2953850501 cites W1907208869 @default.
- W2953850501 cites W1928858456 @default.
- W2953850501 cites W1965515215 @default.
- W2953850501 cites W1968744498 @default.
- W2953850501 cites W1973215369 @default.
- W2953850501 cites W1975869877 @default.
- W2953850501 cites W1976056736 @default.
- W2953850501 cites W1978452405 @default.
- W2953850501 cites W1979552036 @default.
- W2953850501 cites W1983168442 @default.
- W2953850501 cites W1984464701 @default.
- W2953850501 cites W1986684459 @default.
- W2953850501 cites W1989911437 @default.
- W2953850501 cites W1995930136 @default.
- W2953850501 cites W1999594077 @default.
- W2953850501 cites W2001743662 @default.
- W2953850501 cites W2002575276 @default.
- W2953850501 cites W2008820283 @default.
- W2953850501 cites W2009098686 @default.
- W2953850501 cites W2016719416 @default.
- W2953850501 cites W2017822826 @default.
- W2953850501 cites W2019807476 @default.
- W2953850501 cites W2022857316 @default.
- W2953850501 cites W2028491158 @default.
- W2953850501 cites W2030017799 @default.
- W2953850501 cites W2030410575 @default.
- W2953850501 cites W2031305612 @default.
- W2953850501 cites W2031683256 @default.
- W2953850501 cites W2032082746 @default.
- W2953850501 cites W2032097489 @default.
- W2953850501 cites W2032640897 @default.
- W2953850501 cites W2037793614 @default.
- W2953850501 cites W2042207765 @default.
- W2953850501 cites W2046271704 @default.
- W2953850501 cites W2047192512 @default.
- W2953850501 cites W2050150328 @default.
- W2953850501 cites W2050295118 @default.
- W2953850501 cites W2050623701 @default.
- W2953850501 cites W2054072505 @default.
- W2953850501 cites W2057355419 @default.
- W2953850501 cites W2060783095 @default.
- W2953850501 cites W2065554904 @default.
- W2953850501 cites W2067006249 @default.
- W2953850501 cites W2068813102 @default.
- W2953850501 cites W2073934073 @default.
- W2953850501 cites W2076628443 @default.
- W2953850501 cites W2079414409 @default.
- W2953850501 cites W2079576213 @default.
- W2953850501 cites W2080139920 @default.
- W2953850501 cites W2080869463 @default.
- W2953850501 cites W2082762965 @default.
- W2953850501 cites W2083463797 @default.
- W2953850501 cites W2084571480 @default.
- W2953850501 cites W2086287763 @default.
- W2953850501 cites W2088242076 @default.
- W2953850501 cites W2092032160 @default.
- W2953850501 cites W2092699991 @default.
- W2953850501 cites W2093176308 @default.
- W2953850501 cites W2098774733 @default.
- W2953850501 cites W2099482827 @default.
- W2953850501 cites W2101705215 @default.
- W2953850501 cites W2103071242 @default.
- W2953850501 cites W2104524142 @default.
- W2953850501 cites W2113087607 @default.
- W2953850501 cites W2117353004 @default.
- W2953850501 cites W2118574229 @default.
- W2953850501 cites W2124315550 @default.
- W2953850501 cites W2129778797 @default.
- W2953850501 cites W2132332591 @default.
- W2953850501 cites W2132886980 @default.
- W2953850501 cites W2139129373 @default.
- W2953850501 cites W2140355798 @default.
- W2953850501 cites W2143948414 @default.
- W2953850501 cites W2149096917 @default.
- W2953850501 cites W2149346046 @default.
- W2953850501 cites W2152871789 @default.
- W2953850501 cites W2162371396 @default.
- W2953850501 cites W2162947606 @default.
- W2953850501 cites W2180925826 @default.
- W2953850501 cites W2191930106 @default.