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- W2953886223 abstract "Objective: Pediatric systemic lupus erythematosus (PSLE) is a heterogeneous autoimmune disorder of unknown origin. PTPN22 gene polymorphisms have been associated with SLE in different populations. We investigated the associations of the rs2476601, rs1217414, rs33996649, rs1276457, and rs1310182 SNPs in the PTPN22 gene with PSLE. Materials and methods: 55 PSLE patients and 93 healthy controls were recruited. SNPs were genotyped by the real-time PCR allelic discrimination method. Results: We found that the PTPN22 polymorphisms rs1310182 A allele (p = 0.01, OR = 1.92 95% CI = 1.16–3.18), and rs1310182 AA genotype with (p < 0.001) and rs12760457 TT (p = 0.046) were associated with PSLE. No significant associations were found between other SNPs and PSLE. Conclusions: The PTPN22 rs1310182 A allele and rs1310182 AA genotype were associated with PSLE and may be a possible genetic marker for susceptibility to PSLE. However, further investigation would be required to elucidate the mechanistic role of this association." @default.
- W2953886223 created "2019-07-12" @default.
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- W2953886223 date "2019-06-24" @default.
- W2953886223 modified "2023-09-23" @default.
- W2953886223 title "<i>PTPN22</i>Gene Polymorphisms in Pediatric Systemic Lupus Erythematosus" @default.
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- W2953886223 doi "https://doi.org/10.1080/15513815.2019.1630873" @default.
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