FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953891247> ?p ?o ?g. }

• W2953891247 abstract "Abstract Plants use leucine-rich repeat receptor kinases (LRR-RKs) to sense sequence diverse peptide hormones at the cell surface. A 3.0 Å crystal structure of the LRR-RK GSO1/SGN3 regulating Casparian strip formation in the endodermis reveals a large spiral-shaped ectodomain. The domain provides a binding platform for 21 amino-acid CIF peptide ligands, which are tyrosine sulfated by the tyrosylprotein sulfotransferase TPST/SGN2. GSO1/SGN3 harbors a binding pocket for sulfotyrosine and makes extended backbone interactions with CIF2. Quantitative biochemical comparisons reveal that GSO1/SGN3 – CIF2 represents one of the strongest receptor-ligand pairs known in plants. Multiple missense mutations are required to block CIF2 binding in vitro , and GSO1/SGN3 function in vivo . Using structure-guided sequence analysis we uncover novel CIF peptides conserved among higher plants. Quantitative binding assays with known and novel CIFs suggest that the homologous LRR-RKs GSO1/SGN3 and GSO2 have evolved unique peptide binding properties to control different developmental processes. A quantitative biochemical interaction screen, a CIF peptide antagonist and genetic analyses together implicate SERK LRR-RKs as essential co-receptor kinases required for GSO1/SGN3 and GSO2 receptor activation. 0ur work provides a mechanistic framework for the recognition of sequence-divergent peptide hormones in plants. Significance Statement Two sequence-related plant membrane receptor kinases and their shape-complementary co-receptors are shown to selectively sense members of a small family of secreted peptide hormones to control formation of an important diffusion barrier in the plant root." @default.
• W2953891247 created "2019-07-12" @default.
• W2953891247 creator A5003402339 @default.
• W2953891247 creator A5014333835 @default.
• W2953891247 creator A5017104531 @default.
• W2953891247 creator A5024769340 @default.
• W2953891247 creator A5030307663 @default.
• W2953891247 creator A5046132644 @default.
• W2953891247 creator A5053143384 @default.
• W2953891247 creator A5055192188 @default.
• W2953891247 creator A5076626519 @default.
• W2953891247 creator A5089590993 @default.
• W2953891247 date "2019-07-04" @default.
• W2953891247 modified "2023-10-15" @default.
• W2953891247 title "Molecular mechanism for the recognition of sequence-divergent CIF peptides by the plant receptor kinases GSO1/SGN3 and GSO2" @default.
• W2953891247 cites W1479849091 @default.
• W2953891247 cites W1511294303 @default.
• W2953891247 cites W1966128755 @default.
• W2953891247 cites W1996835973 @default.
• W2953891247 cites W1999600272 @default.
• W2953891247 cites W2000840258 @default.
• W2953891247 cites W2008708467 @default.
• W2953891247 cites W2017746652 @default.
• W2953891247 cites W2017995274 @default.
• W2953891247 cites W2020584700 @default.
• W2953891247 cites W2034413096 @default.
• W2953891247 cites W2035503835 @default.
• W2953891247 cites W2044217417 @default.
• W2953891247 cites W2049449151 @default.
• W2953891247 cites W2053427298 @default.
• W2953891247 cites W2078937412 @default.
• W2953891247 cites W2089361961 @default.
• W2953891247 cites W2097242131 @default.
• W2953891247 cites W2112242180 @default.
• W2953891247 cites W2116122104 @default.
• W2953891247 cites W2122339645 @default.
• W2953891247 cites W2123264056 @default.
• W2953891247 cites W2124016442 @default.
• W2953891247 cites W2128288740 @default.
• W2953891247 cites W2140117843 @default.
• W2953891247 cites W2144081223 @default.
• W2953891247 cites W2144362290 @default.
• W2953891247 cites W2161791938 @default.
• W2953891247 cites W2163219308 @default.
• W2953891247 cites W2163341755 @default.
• W2953891247 cites W2167279371 @default.
• W2953891247 cites W2180229411 @default.
• W2953891247 cites W2228103413 @default.
• W2953891247 cites W2315721191 @default.
• W2953891247 cites W2326508739 @default.
• W2953891247 cites W2329700557 @default.
• W2953891247 cites W2403108876 @default.
• W2953891247 cites W2499017151 @default.
• W2953891247 cites W2556869668 @default.
• W2953891247 cites W2560103310 @default.
• W2953891247 cites W2573838227 @default.
• W2953891247 cites W2575748517 @default.
• W2953891247 cites W2621877256 @default.
• W2953891247 cites W2741131137 @default.
• W2953891247 cites W2746949165 @default.
• W2953891247 cites W2768878155 @default.
• W2953891247 cites W2784037295 @default.
• W2953891247 cites W2790282366 @default.
• W2953891247 cites W2794850753 @default.
• W2953891247 cites W2803205867 @default.
• W2953891247 cites W2890346289 @default.
• W2953891247 cites W2943358526 @default.
• W2953891247 doi "https://doi.org/10.1101/692228" @default.
• W2953891247 hasPublicationYear "2019" @default.
• W2953891247 type Work @default.
• W2953891247 sameAs 2953891247 @default.
• W2953891247 citedByCount "1" @default.
• W2953891247 countsByYear W29538912472020 @default.
• W2953891247 crossrefType "posted-content" @default.
• W2953891247 hasAuthorship W2953891247A5003402339 @default.
• W2953891247 hasAuthorship W2953891247A5014333835 @default.
• W2953891247 hasAuthorship W2953891247A5017104531 @default.
• W2953891247 hasAuthorship W2953891247A5024769340 @default.
• W2953891247 hasAuthorship W2953891247A5030307663 @default.
• W2953891247 hasAuthorship W2953891247A5046132644 @default.
• W2953891247 hasAuthorship W2953891247A5053143384 @default.
• W2953891247 hasAuthorship W2953891247A5055192188 @default.
• W2953891247 hasAuthorship W2953891247A5076626519 @default.
• W2953891247 hasAuthorship W2953891247A5089590993 @default.
• W2953891247 hasBestOaLocation W29538912471 @default.
• W2953891247 hasConcept C1009742 @default.
• W2953891247 hasConcept C101544691 @default.
• W2953891247 hasConcept C104317684 @default.
• W2953891247 hasConcept C167625842 @default.
• W2953891247 hasConcept C170493617 @default.
• W2953891247 hasConcept C184235292 @default.
• W2953891247 hasConcept C2779281246 @default.
• W2953891247 hasConcept C55493867 @default.
• W2953891247 hasConcept C86803240 @default.
• W2953891247 hasConcept C95444343 @default.
• W2953891247 hasConceptScore W2953891247C1009742 @default.
• W2953891247 hasConceptScore W2953891247C101544691 @default.
• W2953891247 hasConceptScore W2953891247C104317684 @default.
• W2953891247 hasConceptScore W2953891247C167625842 @default.
• W2953891247 hasConceptScore W2953891247C170493617 @default.

• next