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- W2953896150 abstract "Abstract Cell morphogenesis employs a diversity of membrane protrusions. They are discriminated by differences in force generation. Actin polymerization is the best studied mechanism of force generation, but growing interest in how variable molecular conditions and microenvironments alter morphogenesis has revealed other mechanisms, including intracellular pressure. Here, we show that local depletion of membrane cortex links is an essential step in the initiation of both pressure-based and actin-based protrusions. This observation challenges the quarter-century old Brownian ratchet model of actin-driven membrane protrusion, which requires an optimal balance of actin filament growth and membrane tethering. An updated model confirms membrane-filament detachment is necessary to activate the ratchet mechanism. These findings unify the regulation of different protrusion types, explaining how cells generate robust yet flexible strategies of morphogenesis." @default.
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- W2953896150 date "2019-07-08" @default.
- W2953896150 modified "2023-09-27" @default.
- W2953896150 title "A unified role for membrane-cortex detachment during cell protrusion initiation" @default.
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- W2953896150 doi "https://doi.org/10.1101/696211" @default.
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