FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953909842> ?p ?o ?g. }

• W2953909842 endingPage "279" @default.
• W2953909842 startingPage "271" @default.
• W2953909842 abstract "Sertoli and Leydig cells provide key supporting roles in spermatogenesis. Various toxins have been studied in the TM3 and TM4 mouse testis cell lines to identify their regulatory effects. Alpha-solanine (α-solanine), a toxic compound found in the potato, has cytotoxic effects on various cells, including cancer cells. However, the effect of α-solanine on testis function has not been identified. In this study, we verified for the first time the anti-proliferative effect of α-solanine in mouse testes. α-Solanine reduced cell viability in TM3 and TM4 cells and reduced the expression of the cell cycle checkpoint genes Ccnd1 and Ccne1. We also detected changes in the mitochondrial membrane potential (MMP) and in the cytosolic calcium and intracellular signal pathways in both cell lines. α-Solanine induced AKT, P70S6K, S6, ERK1/2, and JNK activation in mouse testis cells. In addition, the inhibition of AKT with a pharmacological inhibitor (LY294002) demonstrated more synergic anti-proliferative effects than in the TM3 and TM4 cell lines treated only with α-solanine. Inha and Inhba mRNA expression also decreased in both cell lines and α-solanine i.p. injected mouse testes. Collectively, the results from this study verify the toxic effects of α-solanine on testes and male reproductive function." @default.
• W2953909842 created "2019-07-12" @default.
• W2953909842 creator A5023474900 @default.
• W2953909842 creator A5046819938 @default.
• W2953909842 creator A5081217020 @default.
• W2953909842 creator A5086164670 @default.
• W2953909842 date "2019-11-01" @default.
• W2953909842 modified "2023-09-27" @default.
• W2953909842 title "Alpha-solanine inhibits cell proliferation via mitochondrial dysfunction and inhibin synthesis in mouse testis In vitro and In vivo" @default.
• W2953909842 cites W1546841623 @default.
• W2953909842 cites W1973807205 @default.
• W2953909842 cites W1982357280 @default.
• W2953909842 cites W1984781088 @default.
• W2953909842 cites W1991046191 @default.
• W2953909842 cites W1991786188 @default.
• W2953909842 cites W1997492453 @default.
• W2953909842 cites W2002425246 @default.
• W2953909842 cites W2010240511 @default.
• W2953909842 cites W2011731207 @default.
• W2953909842 cites W2025276362 @default.
• W2953909842 cites W2026986598 @default.
• W2953909842 cites W2056583090 @default.
• W2953909842 cites W2058656564 @default.
• W2953909842 cites W2060827874 @default.
• W2953909842 cites W2091743057 @default.
• W2953909842 cites W2093974862 @default.
• W2953909842 cites W2109087415 @default.
• W2953909842 cites W2133282961 @default.
• W2953909842 cites W2149342162 @default.
• W2953909842 cites W2156891215 @default.
• W2953909842 cites W2164229548 @default.
• W2953909842 cites W2175016084 @default.
• W2953909842 cites W2276262372 @default.
• W2953909842 cites W2332017164 @default.
• W2953909842 cites W2343988553 @default.
• W2953909842 cites W2490268341 @default.
• W2953909842 cites W2521642386 @default.
• W2953909842 cites W2530762733 @default.
• W2953909842 cites W2737852119 @default.
• W2953909842 cites W2752314683 @default.
• W2953909842 cites W2754930359 @default.
• W2953909842 cites W2764177986 @default.
• W2953909842 cites W2779680460 @default.
• W2953909842 cites W2788004608 @default.
• W2953909842 cites W2803348133 @default.
• W2953909842 cites W2895947362 @default.
• W2953909842 doi "https://doi.org/10.1016/j.chemosphere.2019.06.172" @default.
• W2953909842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31260867" @default.
• W2953909842 hasPublicationYear "2019" @default.
• W2953909842 type Work @default.
• W2953909842 sameAs 2953909842 @default.
• W2953909842 citedByCount "15" @default.
• W2953909842 countsByYear W29539098422020 @default.
• W2953909842 countsByYear W29539098422021 @default.
• W2953909842 countsByYear W29539098422022 @default.
• W2953909842 countsByYear W29539098422023 @default.
• W2953909842 crossrefType "journal-article" @default.
• W2953909842 hasAuthorship W2953909842A5023474900 @default.
• W2953909842 hasAuthorship W2953909842A5046819938 @default.
• W2953909842 hasAuthorship W2953909842A5081217020 @default.
• W2953909842 hasAuthorship W2953909842A5086164670 @default.
• W2953909842 hasConcept C123765429 @default.
• W2953909842 hasConcept C134018914 @default.
• W2953909842 hasConcept C142724271 @default.
• W2953909842 hasConcept C153911025 @default.
• W2953909842 hasConcept C185592680 @default.
• W2953909842 hasConcept C190283241 @default.
• W2953909842 hasConcept C2776967927 @default.
• W2953909842 hasConcept C2780687663 @default.
• W2953909842 hasConcept C2781068068 @default.
• W2953909842 hasConcept C2781069245 @default.
• W2953909842 hasConcept C29537977 @default.
• W2953909842 hasConcept C54355233 @default.
• W2953909842 hasConcept C55493867 @default.
• W2953909842 hasConcept C62112901 @default.
• W2953909842 hasConcept C62478195 @default.
• W2953909842 hasConcept C71924100 @default.
• W2953909842 hasConcept C75217442 @default.
• W2953909842 hasConcept C81885089 @default.
• W2953909842 hasConcept C86554907 @default.
• W2953909842 hasConcept C86803240 @default.
• W2953909842 hasConcept C95444343 @default.
• W2953909842 hasConceptScore W2953909842C123765429 @default.
• W2953909842 hasConceptScore W2953909842C134018914 @default.
• W2953909842 hasConceptScore W2953909842C142724271 @default.
• W2953909842 hasConceptScore W2953909842C153911025 @default.
• W2953909842 hasConceptScore W2953909842C185592680 @default.
• W2953909842 hasConceptScore W2953909842C190283241 @default.
• W2953909842 hasConceptScore W2953909842C2776967927 @default.
• W2953909842 hasConceptScore W2953909842C2780687663 @default.
• W2953909842 hasConceptScore W2953909842C2781068068 @default.
• W2953909842 hasConceptScore W2953909842C2781069245 @default.
• W2953909842 hasConceptScore W2953909842C29537977 @default.
• W2953909842 hasConceptScore W2953909842C54355233 @default.
• W2953909842 hasConceptScore W2953909842C55493867 @default.
• W2953909842 hasConceptScore W2953909842C62112901 @default.
• W2953909842 hasConceptScore W2953909842C62478195 @default.
• W2953909842 hasConceptScore W2953909842C71924100 @default.

• next