FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2953920201> ?p ?o ?g. }

• W2953920201 abstract "Relevance. A lot of conservative approaches have been proposed to the management of keloids, but none of them provides a guaranteed positive result and a stable absence of relapse.&#x0D; Objective: to evaluate the effectiveness and side effects of triple keloid scar therapy.&#x0D; Materials and methods. Thirty-three patients aged 18-69 years, who received treatment of keloids by triple medicine combination therapy, were investigated retrospectively. All patients were divided into two groups. In first one (16 patients) intralesional injections of mixture of 5-fluorouracil, triamcinolone acetonide and bovine origin hyaluronidase were performed. In the second group (17 patients) instead of triamcinolone betamethasone suspension was used. Four sessions of therapy were performed with a monthly interval. Results were assessed 1 month and 6 months after the last session. The planimetric investigation and measurement of scars’ volume were performed. The influence of treatment on the number of telangiectasias within the scar was performed with the help of our method of computer processing of its digital photographs.&#x0D; Results. There was not statistically significant difference in linear size, area and volume of the scars in patients of two groups before beginning of the treatment. One month after the fourth session scars’ width increased statistically significantly. Their length and area also increased but difference did not reach statistically significant level. At the same time maximal height of the scars over surrounding tissues (p<0.001) and their volume (p=0.012 та 0.001) reduced significantly in both groups. There was not difference in percentage of scar volume reduction ((67.4±18.01) % and (74.3±14.71) % correspondingly, p=0.308) in different groups. The main negative effect of treatment was redness of the scars due to purpura and increase of telangiectasias number. Reliable increase of the part of the scars’ surface taken by the telangiectasias was registered in both groups without difference between them. Despite the overall improvement in self-esteem, the patients noted that the change in the color of the scar after the treatment came into the first plane among the factors causing aesthetic dissatisfaction. Supplementary methods of telangiectasias and hyperemia correction were used in 12 patients of the first and 11 patients of the second group. Pain syndrome and itching were eliminated in 11 out of 14 (78.6%) patients in the first group and in 11 out of 15 (73.3%) patients in the second group (p = 0.753). Performed treatment positively influenced patients’ quality of life. Their self-esteem increased essentially ((3.4±2.16) points, p=0.005 and (3.2±1.92) points, p=0.001 correspondingly). At re-examination 6 months after the termination of triple therapy, no statistically significant changes in the size of scars were found, pain and itching did not restore. The quality of life self-esteem remained unchanged.&#x0D; Conclusion. The combined use of 5-fluorouracil, glucocorticoid, and hyaluronidase reduced the protrusion and volume of not-burn keloids in patients of both groups (by (67.4 ± 18.01) % and (74.3 ± 14.71) % respectively (p = 0.308)). Triple medicine therapy permitted to eliminate the pain syndrome and itching in 78.6 % of patients of group where triamcinolone acetonide was used, and in 73.3% of patients who received mixture that included betamethasone suspension (p=0.753). Triple medicine therapy effectiveness, both in term scars’ resizing, and eliminating clinical symptoms and improving the quality of life, was the same for both variants of the combination of drugs. The main side effect, that somewhat worsened the aesthetic result of treatment, was the increase of telangiectasias number. The part of the scar area taken by telangiectasias increased from the (3.4±1.16) % to the (9.7±3.51) %, p<0.001 in the first group and from the (3.3±1.31) % to the (9.7±3.05) %, p<0.001 in the second one. The use of glucocorticoid in triple therapy, which to a lesser extent will stimulate the formation of telangiectasias, will improve the cosmetic result of the treatment." @default.
• W2953920201 created "2019-07-12" @default.
• W2953920201 creator A5007354930 @default.
• W2953920201 creator A5073554983 @default.
• W2953920201 date "2018-06-21" @default.
• W2953920201 modified "2023-09-27" @default.
• W2953920201 title "KELOIDS TREATMENT USING TRIPLE MEDICINE COMBINATION" @default.
• W2953920201 cites W1521480454 @default.
• W2953920201 cites W1884411269 @default.
• W2953920201 cites W1906822065 @default.
• W2953920201 cites W1967692792 @default.
• W2953920201 cites W1974972454 @default.
• W2953920201 cites W1978602238 @default.
• W2953920201 cites W2001009396 @default.
• W2953920201 cites W2001710040 @default.
• W2953920201 cites W2032303062 @default.
• W2953920201 cites W2032377131 @default.
• W2953920201 cites W2052842827 @default.
• W2953920201 cites W2060604544 @default.
• W2953920201 cites W2062982285 @default.
• W2953920201 cites W2083903831 @default.
• W2953920201 cites W2087624875 @default.
• W2953920201 cites W2099540110 @default.
• W2953920201 cites W2130098890 @default.
• W2953920201 cites W2132263944 @default.
• W2953920201 cites W2145568812 @default.
• W2953920201 cites W2161423477 @default.
• W2953920201 cites W2314209392 @default.
• W2953920201 cites W2414205551 @default.
• W2953920201 cites W2593918601 @default.
• W2953920201 cites W2622107463 @default.
• W2953920201 cites W2738285618 @default.
• W2953920201 cites W2896149028 @default.
• W2953920201 doi "https://doi.org/10.32345/2664-4738.1-2.2018.06" @default.
• W2953920201 hasPublicationYear "2018" @default.
• W2953920201 type Work @default.
• W2953920201 sameAs 2953920201 @default.
• W2953920201 citedByCount "0" @default.
• W2953920201 crossrefType "journal-article" @default.
• W2953920201 hasAuthorship W2953920201A5007354930 @default.
• W2953920201 hasAuthorship W2953920201A5073554983 @default.
• W2953920201 hasBestOaLocation W29539202011 @default.
• W2953920201 hasConcept C126322002 @default.
• W2953920201 hasConcept C141071460 @default.
• W2953920201 hasConcept C16005928 @default.
• W2953920201 hasConcept C2777538232 @default.
• W2953920201 hasConcept C2777642821 @default.
• W2953920201 hasConcept C2778903070 @default.
• W2953920201 hasConcept C2781162121 @default.
• W2953920201 hasConcept C3018023364 @default.
• W2953920201 hasConcept C71924100 @default.
• W2953920201 hasConceptScore W2953920201C126322002 @default.
• W2953920201 hasConceptScore W2953920201C141071460 @default.
• W2953920201 hasConceptScore W2953920201C16005928 @default.
• W2953920201 hasConceptScore W2953920201C2777538232 @default.
• W2953920201 hasConceptScore W2953920201C2777642821 @default.
• W2953920201 hasConceptScore W2953920201C2778903070 @default.
• W2953920201 hasConceptScore W2953920201C2781162121 @default.
• W2953920201 hasConceptScore W2953920201C3018023364 @default.
• W2953920201 hasConceptScore W2953920201C71924100 @default.
• W2953920201 hasLocation W29539202011 @default.
• W2953920201 hasLocation W29539202012 @default.
• W2953920201 hasOpenAccess W2953920201 @default.
• W2953920201 hasPrimaryLocation W29539202011 @default.
• W2953920201 hasRelatedWork W1879475197 @default.
• W2953920201 hasRelatedWork W2001203218 @default.
• W2953920201 hasRelatedWork W2005530413 @default.
• W2953920201 hasRelatedWork W2010213275 @default.
• W2953920201 hasRelatedWork W2096518890 @default.
• W2953920201 hasRelatedWork W2130098890 @default.
• W2953920201 hasRelatedWork W2134341329 @default.
• W2953920201 hasRelatedWork W2160378924 @default.
• W2953920201 hasRelatedWork W2287761597 @default.
• W2953920201 hasRelatedWork W2361548447 @default.
• W2953920201 hasRelatedWork W2623359588 @default.
• W2953920201 hasRelatedWork W2805814326 @default.
• W2953920201 hasRelatedWork W2898697499 @default.
• W2953920201 hasRelatedWork W2937978633 @default.
• W2953920201 hasRelatedWork W2952642224 @default.
• W2953920201 hasRelatedWork W2971477803 @default.
• W2953920201 hasRelatedWork W3126415555 @default.
• W2953920201 hasRelatedWork W3167541822 @default.
• W2953920201 hasRelatedWork W3191464866 @default.
• W2953920201 hasRelatedWork W2907426119 @default.
• W2953920201 isParatext "false" @default.
• W2953920201 isRetracted "false" @default.
• W2953920201 magId "2953920201" @default.
• W2953920201 workType "article" @default.