FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954008672> ?p ?o ?g. }

• W2954008672 abstract "The effect of the activation of the mitochondrial ATP-dependent potassium channel (mitoKATP) on the ultrastructure of rat lung in acute hypoxic hypoxia (7% of oxygen in nitrogen, exposure 30 min) was studied. It was shown that uridine, a precursor of the mitoKATP activator UDP, exerted a protective effect against hypoxic damage to the lung. The administration of uridine to animals prior to hypoxia decreased the number of mitochondria with altered ultrastructure and prevented the hypoxia-induced mitochondrial swelling. Uridine also protected the epithelial, interstitial and endothelial layers of the air-blood barrier from the hypoxia-induced hyperhydration. The protective action of uridine against hypoxia-induced lung injury was eliminated by the selective blocker of mitoKATP 5-hydroxydecanoate. These data suggest that one of the mechanisms of the positive effect of uridine is related to the activation of the mitoKATP channel, which, according to the literature and our data, is involved in the protection of tissues from hypoxia and leads to adaptation to it. A possible role of uridine in the maintenance of the mitochondrial structure upon hypoxia-induced lung injury and the optimization of oxygen supply of the organism is discussed." @default.
• W2954008672 created "2019-07-12" @default.
• W2954008672 creator A5015391374 @default.
• W2954008672 creator A5045466260 @default.
• W2954008672 creator A5075051000 @default.
• W2954008672 creator A5083820722 @default.
• W2954008672 creator A5090002711 @default.
• W2954008672 date "2019-07-01" @default.
• W2954008672 modified "2023-10-13" @default.
• W2954008672 title "Uridine as a protector against hypoxia-induced lung injury" @default.
• W2954008672 cites W1854633548 @default.
• W2954008672 cites W1896993274 @default.
• W2954008672 cites W1970672273 @default.
• W2954008672 cites W1980307873 @default.
• W2954008672 cites W1994553865 @default.
• W2954008672 cites W1996080324 @default.
• W2954008672 cites W2006828513 @default.
• W2954008672 cites W2009574988 @default.
• W2954008672 cites W2027613805 @default.
• W2954008672 cites W2028994548 @default.
• W2954008672 cites W2049135660 @default.
• W2954008672 cites W2061558678 @default.
• W2954008672 cites W2089089301 @default.
• W2954008672 cites W2090684431 @default.
• W2954008672 cites W2100405364 @default.
• W2954008672 cites W2105362350 @default.
• W2954008672 cites W2116040786 @default.
• W2954008672 cites W2123900852 @default.
• W2954008672 cites W2129363868 @default.
• W2954008672 cites W2157659024 @default.
• W2954008672 cites W2294562584 @default.
• W2954008672 cites W2299878284 @default.
• W2954008672 cites W2300573041 @default.
• W2954008672 cites W2356307563 @default.
• W2954008672 cites W2402908635 @default.
• W2954008672 cites W2422312617 @default.
• W2954008672 cites W2542385118 @default.
• W2954008672 cites W2562137041 @default.
• W2954008672 cites W2792581798 @default.
• W2954008672 cites W2883305781 @default.
• W2954008672 doi "https://doi.org/10.1038/s41598-019-45979-2" @default.
• W2954008672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6602925" @default.
• W2954008672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31263219" @default.
• W2954008672 hasPublicationYear "2019" @default.
• W2954008672 type Work @default.
• W2954008672 sameAs 2954008672 @default.
• W2954008672 citedByCount "9" @default.
• W2954008672 countsByYear W29540086722020 @default.
• W2954008672 countsByYear W29540086722021 @default.
• W2954008672 countsByYear W29540086722022 @default.
• W2954008672 countsByYear W29540086722023 @default.
• W2954008672 crossrefType "journal-article" @default.
• W2954008672 hasAuthorship W2954008672A5015391374 @default.
• W2954008672 hasAuthorship W2954008672A5045466260 @default.
• W2954008672 hasAuthorship W2954008672A5075051000 @default.
• W2954008672 hasAuthorship W2954008672A5083820722 @default.
• W2954008672 hasAuthorship W2954008672A5090002711 @default.
• W2954008672 hasBestOaLocation W29540086721 @default.
• W2954008672 hasConcept C104317684 @default.
• W2954008672 hasConcept C126322002 @default.
• W2954008672 hasConcept C178790620 @default.
• W2954008672 hasConcept C185592680 @default.
• W2954008672 hasConcept C2777714996 @default.
• W2954008672 hasConcept C2781259782 @default.
• W2954008672 hasConcept C28859421 @default.
• W2954008672 hasConcept C540031477 @default.
• W2954008672 hasConcept C55493867 @default.
• W2954008672 hasConcept C67705224 @default.
• W2954008672 hasConcept C71924100 @default.
• W2954008672 hasConcept C7836513 @default.
• W2954008672 hasConcept C86803240 @default.
• W2954008672 hasConcept C88045685 @default.
• W2954008672 hasConcept C95444343 @default.
• W2954008672 hasConcept C98274493 @default.
• W2954008672 hasConceptScore W2954008672C104317684 @default.
• W2954008672 hasConceptScore W2954008672C126322002 @default.
• W2954008672 hasConceptScore W2954008672C178790620 @default.
• W2954008672 hasConceptScore W2954008672C185592680 @default.
• W2954008672 hasConceptScore W2954008672C2777714996 @default.
• W2954008672 hasConceptScore W2954008672C2781259782 @default.
• W2954008672 hasConceptScore W2954008672C28859421 @default.
• W2954008672 hasConceptScore W2954008672C540031477 @default.
• W2954008672 hasConceptScore W2954008672C55493867 @default.
• W2954008672 hasConceptScore W2954008672C67705224 @default.
• W2954008672 hasConceptScore W2954008672C71924100 @default.
• W2954008672 hasConceptScore W2954008672C7836513 @default.
• W2954008672 hasConceptScore W2954008672C86803240 @default.
• W2954008672 hasConceptScore W2954008672C88045685 @default.
• W2954008672 hasConceptScore W2954008672C95444343 @default.
• W2954008672 hasConceptScore W2954008672C98274493 @default.
• W2954008672 hasFunder F4320321079 @default.
• W2954008672 hasFunder F4320324099 @default.
• W2954008672 hasIssue "1" @default.
• W2954008672 hasLocation W29540086721 @default.
• W2954008672 hasLocation W29540086722 @default.
• W2954008672 hasLocation W29540086723 @default.
• W2954008672 hasLocation W29540086724 @default.
• W2954008672 hasOpenAccess W2954008672 @default.
• W2954008672 hasPrimaryLocation W29540086721 @default.
• W2954008672 hasRelatedWork W1607819183 @default.

• next