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• W2954018630 abstract "To fully exploit the potential of single-cell functional genomics in the study of development and disease, robust methods are needed to simplify the analysis of data across samples, time-points and individuals. Here we introduce a model-based factor analysis method, SDA, to analyze a novel 57,600 cell dataset from the testes of wild-type mice and mice with gonadal defects due to disruption of the genes Mlh3, Hormad1, Cul4a or Cnp. By jointly analyzing mutant and wild-type cells we decomposed our data into 46 components that identify novel meiotic gene-regulatory programs, mutant-specific pathological processes, and technical effects, and provide a framework for imputation. We identify, de novo, DNA sequence motifs associated with individual components that define temporally varying modes of gene expression control. Analysis of SDA components also led us to identify a rare population of macrophages within the seminiferous tubules of Mlh3-/- and Hormad1-/- mice, an area typically associated with immune privilege." @default.
• W2954018630 created "2019-07-12" @default.
• W2954018630 creator A5006738143 @default.
• W2954018630 creator A5023313290 @default.
• W2954018630 creator A5041774208 @default.
• W2954018630 creator A5050987953 @default.
• W2954018630 creator A5051043751 @default.
• W2954018630 creator A5052165531 @default.
• W2954018630 creator A5053073178 @default.
• W2954018630 date "2019-06-25" @default.
• W2954018630 modified "2023-10-13" @default.
• W2954018630 title "Unified single-cell analysis of testis gene regulation and pathology in five mouse strains" @default.
• W2954018630 cites W1013199396 @default.
• W2954018630 cites W1422452898 @default.
• W2954018630 cites W1542752220 @default.
• W2954018630 cites W1641263323 @default.
• W2954018630 cites W1709815505 @default.
• W2954018630 cites W1786442921 @default.
• W2954018630 cites W1860923284 @default.
• W2954018630 cites W1870600368 @default.
• W2954018630 cites W1963756058 @default.
• W2954018630 cites W1965388986 @default.
• W2954018630 cites W1969901238 @default.
• W2954018630 cites W1970283686 @default.
• W2954018630 cites W1974717740 @default.
• W2954018630 cites W1975334494 @default.
• W2954018630 cites W1980549702 @default.
• W2954018630 cites W1981979988 @default.
• W2954018630 cites W1986192649 @default.
• W2954018630 cites W1992077773 @default.
• W2954018630 cites W1996599185 @default.
• W2954018630 cites W2001246746 @default.
• W2954018630 cites W2001758686 @default.
• W2954018630 cites W2002454928 @default.
• W2954018630 cites W2004413158 @default.
• W2954018630 cites W2012034410 @default.
• W2954018630 cites W2018138402 @default.
• W2954018630 cites W2018838463 @default.
• W2954018630 cites W2022577704 @default.
• W2954018630 cites W2026469163 @default.
• W2954018630 cites W2030712966 @default.
• W2954018630 cites W2033793905 @default.
• W2954018630 cites W2035618305 @default.
• W2954018630 cites W2037055772 @default.
• W2954018630 cites W2037818631 @default.
• W2954018630 cites W2040017195 @default.
• W2954018630 cites W2042925640 @default.
• W2954018630 cites W2043851579 @default.
• W2954018630 cites W2047657819 @default.
• W2954018630 cites W2050815879 @default.
• W2954018630 cites W2054067310 @default.
• W2954018630 cites W2056566784 @default.
• W2954018630 cites W2058176738 @default.
• W2954018630 cites W2063292930 @default.
• W2954018630 cites W2064446194 @default.
• W2954018630 cites W2064690543 @default.
• W2954018630 cites W2067135122 @default.
• W2954018630 cites W2068866340 @default.
• W2954018630 cites W2073365040 @default.
• W2954018630 cites W2073738799 @default.
• W2954018630 cites W2080484525 @default.
• W2954018630 cites W2086250805 @default.
• W2954018630 cites W2092764328 @default.
• W2954018630 cites W2097891387 @default.
• W2954018630 cites W2099943594 @default.
• W2954018630 cites W2102212449 @default.
• W2954018630 cites W2103777723 @default.
• W2954018630 cites W2107945594 @default.
• W2954018630 cites W2112363802 @default.
• W2954018630 cites W2114104545 @default.
• W2954018630 cites W2116321167 @default.
• W2954018630 cites W2118015545 @default.
• W2954018630 cites W2120892748 @default.
• W2954018630 cites W2122954165 @default.
• W2954018630 cites W2125663691 @default.
• W2954018630 cites W2129097232 @default.
• W2954018630 cites W2133403778 @default.
• W2954018630 cites W2133894023 @default.
• W2954018630 cites W2135607284 @default.
• W2954018630 cites W2136787567 @default.
• W2954018630 cites W2139696807 @default.
• W2954018630 cites W2145825942 @default.
• W2954018630 cites W2148541040 @default.
• W2954018630 cites W2151778936 @default.
• W2954018630 cites W2160762623 @default.
• W2954018630 cites W2161758325 @default.
• W2954018630 cites W2164353716 @default.
• W2954018630 cites W2169456326 @default.
• W2954018630 cites W2192255382 @default.
• W2954018630 cites W2214918006 @default.
• W2954018630 cites W2219596071 @default.
• W2954018630 cites W2220933714 @default.
• W2954018630 cites W2236442446 @default.
• W2954018630 cites W2256812860 @default.
• W2954018630 cites W2257489030 @default.
• W2954018630 cites W2269758801 @default.
• W2954018630 cites W2275186331 @default.
• W2954018630 cites W2281478543 @default.
• W2954018630 cites W2282317268 @default.
• W2954018630 cites W2286142055 @default.

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