FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954022024> ?p ?o ?g. }

• W2954022024 endingPage "1912" @default.
• W2954022024 startingPage "1912" @default.
• W2954022024 abstract "Diffuse large B cell lymphoma (DLBCL) is a heterogenous disease that has been distinguished into at least two major molecular entities, the germinal center-like B cell (GCB) DLBCL and activated-like B cell (ABC) DLBCL, based on transcriptome expression profiling. A recurrent ch11q24.3 gain is observed in roughly a fourth of DLBCL cases resulting in the overexpression of two ETS transcription factor family members, ETS1 and FLI1. Here, we knocked down ETS1 expression by siRNA and analyzed expression changes integrating them with ChIP-seq data to identify genes directly regulated by ETS1. ETS1 silencing affected expression of genes involved in B cell signaling activation, B cell differentiation, cell cycle, and immune processes. Integration of RNA-Seq (RNA sequencing) data and ChIP-Seq (chromatin immunoprecipitation sequencing) identified 97 genes as bona fide, positively regulated direct targets of ETS1 in ABC-DLBCL. Among these was the Fc receptor for IgM, FCMR (also known as FAIM3 or Toso), which showed higher expression in ABC- than GCB-DLBCL clinical specimens. These findings show that ETS1 is contributing to the lymphomagenesis in a subset of DLBCL and identifies FCMR as a novel target of ETS1, predominantly expressed in ABC-DLBCL." @default.
• W2954022024 created "2019-07-12" @default.
• W2954022024 creator A5007167867 @default.
• W2954022024 creator A5009234092 @default.
• W2954022024 creator A5012537023 @default.
• W2954022024 creator A5013747036 @default.
• W2954022024 creator A5014403308 @default.
• W2954022024 creator A5015790909 @default.
• W2954022024 creator A5016760892 @default.
• W2954022024 creator A5020962624 @default.
• W2954022024 creator A5037493613 @default.
• W2954022024 creator A5039142430 @default.
• W2954022024 creator A5039188583 @default.
• W2954022024 creator A5047236032 @default.
• W2954022024 creator A5066518317 @default.
• W2954022024 creator A5073945848 @default.
• W2954022024 creator A5077930649 @default.
• W2954022024 creator A5079771818 @default.
• W2954022024 date "2020-07-15" @default.
• W2954022024 modified "2023-10-14" @default.
• W2954022024 title "Role of ETS1 in the Transcriptional Network of Diffuse Large B Cell Lymphoma of the Activated B Cell-Like Type" @default.
• W2954022024 cites W1614801520 @default.
• W2954022024 cites W1647059547 @default.
• W2954022024 cites W1769620789 @default.
• W2954022024 cites W1801682147 @default.
• W2954022024 cites W1804456496 @default.
• W2954022024 cites W1889485333 @default.
• W2954022024 cites W1916587252 @default.
• W2954022024 cites W1951934566 @default.
• W2954022024 cites W1971659434 @default.
• W2954022024 cites W1972805802 @default.
• W2954022024 cites W1973340070 @default.
• W2954022024 cites W2013320104 @default.
• W2954022024 cites W2019913536 @default.
• W2954022024 cites W2032088412 @default.
• W2954022024 cites W2037428417 @default.
• W2954022024 cites W2037796411 @default.
• W2954022024 cites W2037904581 @default.
• W2954022024 cites W2039746209 @default.
• W2954022024 cites W2041497115 @default.
• W2954022024 cites W2045273474 @default.
• W2954022024 cites W2047342587 @default.
• W2954022024 cites W2055709915 @default.
• W2954022024 cites W2057358582 @default.
• W2954022024 cites W2058687263 @default.
• W2954022024 cites W2066487093 @default.
• W2954022024 cites W2090316299 @default.
• W2954022024 cites W2108244474 @default.
• W2954022024 cites W2114675572 @default.
• W2954022024 cites W2126616111 @default.
• W2954022024 cites W2130294014 @default.
• W2954022024 cites W2131309445 @default.
• W2954022024 cites W2132608570 @default.
• W2954022024 cites W2133131759 @default.
• W2954022024 cites W2133345063 @default.
• W2954022024 cites W2136309995 @default.
• W2954022024 cites W2136550451 @default.
• W2954022024 cites W2139429481 @default.
• W2954022024 cites W2144451670 @default.
• W2954022024 cites W2149664784 @default.
• W2954022024 cites W2154499883 @default.
• W2954022024 cites W2169849153 @default.
• W2954022024 cites W2178122647 @default.
• W2954022024 cites W2536954905 @default.
• W2954022024 cites W2544405043 @default.
• W2954022024 cites W2570881722 @default.
• W2954022024 cites W2580655888 @default.
• W2954022024 cites W2597805413 @default.
• W2954022024 cites W2612734518 @default.
• W2954022024 cites W2753595907 @default.
• W2954022024 cites W2765262832 @default.
• W2954022024 cites W2791328101 @default.
• W2954022024 cites W2800080453 @default.
• W2954022024 cites W2801763724 @default.
• W2954022024 cites W2893946769 @default.
• W2954022024 cites W2941404034 @default.
• W2954022024 cites W2943161370 @default.
• W2954022024 cites W2952176762 @default.
• W2954022024 cites W3012464003 @default.
• W2954022024 cites W3016044607 @default.
• W2954022024 doi "https://doi.org/10.3390/cancers12071912" @default.
• W2954022024 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7409072" @default.
• W2954022024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32679859" @default.
• W2954022024 hasPublicationYear "2020" @default.
• W2954022024 type Work @default.
• W2954022024 sameAs 2954022024 @default.
• W2954022024 citedByCount "4" @default.
• W2954022024 countsByYear W29540220242021 @default.
• W2954022024 countsByYear W29540220242022 @default.
• W2954022024 countsByYear W29540220242023 @default.
• W2954022024 crossrefType "journal-article" @default.
• W2954022024 hasAuthorship W2954022024A5007167867 @default.
• W2954022024 hasAuthorship W2954022024A5009234092 @default.
• W2954022024 hasAuthorship W2954022024A5012537023 @default.
• W2954022024 hasAuthorship W2954022024A5013747036 @default.
• W2954022024 hasAuthorship W2954022024A5014403308 @default.
• W2954022024 hasAuthorship W2954022024A5015790909 @default.
• W2954022024 hasAuthorship W2954022024A5016760892 @default.

• next