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- W2954037135 abstract "Most large pharmaceutical companies have downscaled or closed their clinical neuroscience research programs in response to the low clinical success rate for drugs that showed tremendous promise in animal experiments intended to model psychiatric pathophysiology. These failures have raised serious concerns about the role of preclinical research in the identification and evaluation of new pharmacotherapies for psychiatry. In the absence of a comprehensive understanding of the neurobiology of psychiatric disorders, the task of developing “animal models” seems elusive. The purpose of this review is to highlight emerging strategies to enhance the utility of preclinical research in the drug development process. We address this issue by reviewing how advances in neuroscience, coupled with new conceptual approaches, have recently revolutionized the way we can diagnose and treat common psychiatric conditions. We discuss the implications of these new tools for modeling psychiatric conditions in animals and advocate for the use of systematic reviews of preclinical work as a prerequisite for conducting psychiatric clinical trials. We believe that work in animals is essential for elucidating human psychopathology and that improving the predictive validity of animal models is necessary for developing more effective interventions for mental illness." @default.
- W2954037135 created "2019-07-12" @default.
- W2954037135 creator A5002896292 @default.
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- W2954037135 creator A5071039477 @default.
- W2954037135 creator A5082466876 @default.
- W2954037135 date "2019-01-01" @default.
- W2954037135 modified "2023-09-27" @default.
- W2954037135 title "Enhancing the Utility of Preclinical Research in Neuropsychiatry Drug Development" @default.
- W2954037135 cites W137181320 @default.
- W2954037135 cites W14049348 @default.
- W2954037135 cites W1581771528 @default.
- W2954037135 cites W1662235811 @default.
- W2954037135 cites W1719300997 @default.
- W2954037135 cites W1891681766 @default.
- W2954037135 cites W1927796084 @default.
- W2954037135 cites W1944272128 @default.
- W2954037135 cites W1964057931 @default.
- W2954037135 cites W1964627324 @default.
- W2954037135 cites W1974420087 @default.
- W2954037135 cites W1975218744 @default.
- W2954037135 cites W1977465442 @default.
- W2954037135 cites W1978686840 @default.
- W2954037135 cites W1979990721 @default.
- W2954037135 cites W1982298072 @default.
- W2954037135 cites W1985603549 @default.
- W2954037135 cites W1987834950 @default.
- W2954037135 cites W1990151307 @default.
- W2954037135 cites W1996280829 @default.
- W2954037135 cites W1998980503 @default.
- W2954037135 cites W2000209446 @default.
- W2954037135 cites W2003973869 @default.
- W2954037135 cites W2004118951 @default.
- W2954037135 cites W2007739659 @default.
- W2954037135 cites W2007816528 @default.
- W2954037135 cites W2011526626 @default.
- W2954037135 cites W2012342199 @default.
- W2954037135 cites W2013016395 @default.
- W2954037135 cites W2024950964 @default.
- W2954037135 cites W2038138464 @default.
- W2954037135 cites W2048701325 @default.
- W2954037135 cites W2049703902 @default.
- W2954037135 cites W2051089361 @default.
- W2954037135 cites W2051458338 @default.
- W2954037135 cites W2058396187 @default.
- W2954037135 cites W2062376845 @default.
- W2954037135 cites W2068478010 @default.
- W2954037135 cites W2071358231 @default.
- W2954037135 cites W2071419830 @default.
- W2954037135 cites W2071635877 @default.
- W2954037135 cites W2075757880 @default.
- W2954037135 cites W2079203942 @default.
- W2954037135 cites W2080496806 @default.
- W2954037135 cites W2083022185 @default.
- W2954037135 cites W2086313373 @default.
- W2954037135 cites W2088714934 @default.
- W2954037135 cites W2089613882 @default.
- W2954037135 cites W2089993812 @default.
- W2954037135 cites W2090851494 @default.
- W2954037135 cites W2090985998 @default.
- W2954037135 cites W2091345402 @default.
- W2954037135 cites W2095996740 @default.
- W2954037135 cites W2100027531 @default.
- W2954037135 cites W2109761979 @default.
- W2954037135 cites W2111038577 @default.
- W2954037135 cites W2113374471 @default.
- W2954037135 cites W2118238128 @default.
- W2954037135 cites W2118347738 @default.
- W2954037135 cites W2119279206 @default.
- W2954037135 cites W2120184832 @default.
- W2954037135 cites W2122745354 @default.
- W2954037135 cites W2124035485 @default.
- W2954037135 cites W2125029186 @default.
- W2954037135 cites W2128010155 @default.
- W2954037135 cites W2130424909 @default.
- W2954037135 cites W2131167630 @default.
- W2954037135 cites W2133108957 @default.
- W2954037135 cites W2133304638 @default.
- W2954037135 cites W2134555567 @default.
- W2954037135 cites W2135080231 @default.
- W2954037135 cites W2136936616 @default.
- W2954037135 cites W2138977668 @default.
- W2954037135 cites W2143629083 @default.
- W2954037135 cites W2147270524 @default.
- W2954037135 cites W2148239317 @default.
- W2954037135 cites W2150691073 @default.
- W2954037135 cites W2151488696 @default.
- W2954037135 cites W2151926428 @default.
- W2954037135 cites W2154708789 @default.
- W2954037135 cites W2158553737 @default.
- W2954037135 cites W2160028381 @default.
- W2954037135 cites W2162313714 @default.
- W2954037135 cites W2165333049 @default.
- W2954037135 cites W2167720733 @default.
- W2954037135 cites W2180085345 @default.
- W2954037135 cites W2237631658 @default.
- W2954037135 cites W2274785614 @default.