FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954049377> ?p ?o ?g. }

• W2954049377 abstract "It has been proposed that peroxisome proliferator-activated receptor-γ (PPARγ) agonists might reduce renal fibrosis, however, several studies had contradictory results. Moreover, the possible interaction of TGF-β1, PPARγ, and transcription factors in renal fibrosis have not been investigated. We hypothesized that oral pioglitazone treatment would inhibit TGF-β-driven renal fibrosis and its progression, by modulating profibrotic transcription factors in TGF-β1 transgenic mice.Male C57Bl/6 J mice (control, CTL, n = 14) and TGF-β overexpressing transgenic mice (TGFβ, n = 14, having elevated plasma TGF-β1 level) were divided in two sets at 10 weeks of age. Mice in the first set were fed with regular rodent chow (CTL and TGFβ, n = 7/group). Mice in the second set were fed with chow containing pioglitazone (at a dose of 20 mg/kg/day, CTL + Pio and TGFβ+Pio, n = 7/group). After 5 weeks of treatment, blood pressure was assessed and urine samples were collected, and the kidneys were analyzed for histology, mRNA and protein expression.TGF-β1 induced glomerulosclerosis and tubulointerstitial damage were significantly reduced by pioglitazone. Pioglitazone inhibited renal mRNA expression of all the profibrotic effectors: type-III collagen, TGF-β1, CTGF and TIMP-1, and alike transcription factors cFos/cJun and protein expression of EGR-1, and STAT3 protein phosphorylation.Oral administration of PPARγ agonist pioglitazone significantly reduces TGF-β1-driven renal fibrosis, via the attenuation of EGR-1, STAT3 and AP-1. This implies that PPARγ agonists might be effective in the treatment of chronic kidney disease patients." @default.
• W2954049377 created "2019-07-12" @default.
• W2954049377 creator A5009139896 @default.
• W2954049377 creator A5024662322 @default.
• W2954049377 creator A5054873598 @default.
• W2954049377 creator A5068266000 @default.
• W2954049377 creator A5073812680 @default.
• W2954049377 date "2019-07-05" @default.
• W2954049377 modified "2023-10-09" @default.
• W2954049377 title "The PPARγ agonist pioglitazone prevents TGF-β induced renal fibrosis by repressing EGR-1 and STAT3" @default.
• W2954049377 cites W1484016032 @default.
• W2954049377 cites W1943161153 @default.
• W2954049377 cites W1975405608 @default.
• W2954049377 cites W1976454629 @default.
• W2954049377 cites W1980325398 @default.
• W2954049377 cites W1982976290 @default.
• W2954049377 cites W1995049975 @default.
• W2954049377 cites W2001370885 @default.
• W2954049377 cites W2002670032 @default.
• W2954049377 cites W2007586155 @default.
• W2954049377 cites W2012532020 @default.
• W2954049377 cites W2014763555 @default.
• W2954049377 cites W2021644664 @default.
• W2954049377 cites W2024059588 @default.
• W2954049377 cites W2027819891 @default.
• W2954049377 cites W2035838779 @default.
• W2954049377 cites W2036224418 @default.
• W2954049377 cites W2042426555 @default.
• W2954049377 cites W2056894900 @default.
• W2954049377 cites W2082401103 @default.
• W2954049377 cites W2085133650 @default.
• W2954049377 cites W2088829415 @default.
• W2954049377 cites W2090801607 @default.
• W2954049377 cites W2103031848 @default.
• W2954049377 cites W2108698393 @default.
• W2954049377 cites W2122808924 @default.
• W2954049377 cites W2137263316 @default.
• W2954049377 cites W2143770053 @default.
• W2954049377 cites W2161162374 @default.
• W2954049377 cites W2274836352 @default.
• W2954049377 cites W2307614235 @default.
• W2954049377 cites W2319066204 @default.
• W2954049377 cites W2398853487 @default.
• W2954049377 cites W2476542314 @default.
• W2954049377 cites W2610276095 @default.
• W2954049377 cites W2732931893 @default.
• W2954049377 cites W2753798482 @default.
• W2954049377 cites W2791419854 @default.
• W2954049377 cites W4245689467 @default.
• W2954049377 cites W4376595379 @default.
• W2954049377 cites W7538965 @default.
• W2954049377 cites W98196760 @default.
• W2954049377 doi "https://doi.org/10.1186/s12882-019-1431-x" @default.
• W2954049377 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6610924" @default.
• W2954049377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31277592" @default.
• W2954049377 hasPublicationYear "2019" @default.
• W2954049377 type Work @default.
• W2954049377 sameAs 2954049377 @default.
• W2954049377 citedByCount "43" @default.
• W2954049377 countsByYear W29540493772020 @default.
• W2954049377 countsByYear W29540493772021 @default.
• W2954049377 countsByYear W29540493772022 @default.
• W2954049377 countsByYear W29540493772023 @default.
• W2954049377 crossrefType "journal-article" @default.
• W2954049377 hasAuthorship W2954049377A5009139896 @default.
• W2954049377 hasAuthorship W2954049377A5024662322 @default.
• W2954049377 hasAuthorship W2954049377A5054873598 @default.
• W2954049377 hasAuthorship W2954049377A5068266000 @default.
• W2954049377 hasAuthorship W2954049377A5073812680 @default.
• W2954049377 hasBestOaLocation W29540493771 @default.
• W2954049377 hasConcept C118131993 @default.
• W2954049377 hasConcept C126322002 @default.
• W2954049377 hasConcept C134018914 @default.
• W2954049377 hasConcept C170493617 @default.
• W2954049377 hasConcept C187345961 @default.
• W2954049377 hasConcept C2775960820 @default.
• W2954049377 hasConcept C2777180221 @default.
• W2954049377 hasConcept C2777390665 @default.
• W2954049377 hasConcept C2778384471 @default.
• W2954049377 hasConcept C2778938600 @default.
• W2954049377 hasConcept C2779561371 @default.
• W2954049377 hasConcept C2780091579 @default.
• W2954049377 hasConcept C2780559512 @default.
• W2954049377 hasConcept C2780631158 @default.
• W2954049377 hasConcept C54847362 @default.
• W2954049377 hasConcept C555293320 @default.
• W2954049377 hasConcept C71924100 @default.
• W2954049377 hasConceptScore W2954049377C118131993 @default.
• W2954049377 hasConceptScore W2954049377C126322002 @default.
• W2954049377 hasConceptScore W2954049377C134018914 @default.
• W2954049377 hasConceptScore W2954049377C170493617 @default.
• W2954049377 hasConceptScore W2954049377C187345961 @default.
• W2954049377 hasConceptScore W2954049377C2775960820 @default.
• W2954049377 hasConceptScore W2954049377C2777180221 @default.
• W2954049377 hasConceptScore W2954049377C2777390665 @default.
• W2954049377 hasConceptScore W2954049377C2778384471 @default.
• W2954049377 hasConceptScore W2954049377C2778938600 @default.
• W2954049377 hasConceptScore W2954049377C2779561371 @default.
• W2954049377 hasConceptScore W2954049377C2780091579 @default.
• W2954049377 hasConceptScore W2954049377C2780559512 @default.

• next