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• W2954069360 abstract "Membranoproliferative (mesangiocapillary) glomerulonephritis (MPGN) is an uncommon cause of end stage kidney disease (ESKD). We describe the dialysis and kidney transplant outcomes of patients with ESKD secondary to MPGN using patient records from the Australian and New Zealand Dialysis and Transplant (ANZDATA) Registry. All patients with ESKD secondary to glomerulonephritis who commenced dialysis or kidney transplantation in Australia and New Zealand between 1996 and 2016 were included. Patients with ESKD secondary to MPGN were compared to those with ESKD secondary to any other glomerulonephritis (other GNs) using a 1:4 propensity score (PS) matched case-control analysis. Patient and death-censored renal allograft survival were analysed by Kaplan-Meier and multivariable Cox proportional hazards model regression. Competing risk regression was performed as a sensitivity analysis. Competing risks were transplantation and renal recovery for dialysis patient survival, allograft failure for transplant patient survival and patient death for death-censored allograft survival. There were 456 patients with ESKD secondary to MPGN and 12,660 patients with ESKD from other GNs. Patients with MPGN were more likely to be Maori or Pacific Islander (15% vs. 7%, p<0.01) or have hepatitis C (10% vs. 1%, p<0.01). In the PS-matched case-control analysis, patients with MPGN experienced lower 10-year dialysis survival rates compared to those with other GNs (30% vs. 39%, p<0.01; Cox adjusted hazard ratio [HR] 1.22, 95% CI 1.01-1.4; competing risk HR 1.16, 95% CI 0.98-1.27). Following kidney transplantation, patients with MPGN (n=190) experienced poorer death-censored graft survival compared with patients with other GNs (n=5519) (10 year survival 62% vs. 75%, p=0.04; Cox-adjusted HR 1.51, CI 1.09-2.08; competing risk HR 1.50, 95% CI 1.13-1.99). Disease relapse was the second most common cause of graft loss in patients with MPGN after rejection and was significantly more common than in patients with other GNs (32% vs. 6%, p<0.01). Overall transplant patient survival was comparable between the two groups (10 year survival 89% vs. 90%, p=0.96; Cox-adjusted HR 0.82, CI 0.42-1.58; competing risk HR 0.96, 95% CI 0.56-1.64). Compared with other forms of glomerulonephritis, patients with MPGN have poorer survival on dialysis and, following kidney transplantation, have poorer allograft survival primarily due to a significantly increased risk of disease relapse. Patients of Maori and Pacific Islander ethnicity or those with hepatitis C have a significantly increased risk of developing MPGN." @default.
• W2954069360 created "2019-07-12" @default.
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• W2954069360 date "2019-07-01" @default.
• W2954069360 modified "2023-09-26" @default.
• W2954069360 title "SUN-041 THE CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH END STAGE KIDNEY DISEASE SECONDARY TO MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS IN AUSTRALIA AND NEW ZEALAND" @default.
• W2954069360 doi "https://doi.org/10.1016/j.ekir.2019.05.436" @default.
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