Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954069384> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2954069384 endingPage "S82" @default.
- W2954069384 startingPage "S81" @default.
- W2954069384 abstract "Chronic kidney disease usually has no characteristic symptoms. The processes started in childhood often lead to end-stage renal failure in the future. Commonly used markers of renal function (creatinine, cystatin c, albuminuria, eGFR) do not have high sensitivity. Therefore, searching for candidates for an early, sensitive and specific biomarker became very popular. The tested new biomarkers may be more useful in the pediatric population than in adult patients, as children are usually not affected by other non-renal pathologies that may influence the results. There are several concepts of risk factors for chronic kidney disease: e.g. post-inflammatory scarring in renoscintigraphy and glomerular hyperfiltration. The aim of the study is the apraisal of the usefulness of new markers: KIM-1, FGF-23, NAG, NGAL, uromodulin in monitoring early stage of renal damage in children. 59 children (15 boys, 44 girls from 6 months to 17 years old) with kidney disorders, which had clinical indications for renoscintigraphy, were included in the study. The exclusion criteria were: elevated creatinine level, albuminuria, proteinuria, hypertension. Firstly, all patients were divided depending on the result of renoscintigraphy: the study group consisted of children with renal scarring, the control group consisted of children with normal kidney picture. Secondly, all patients were divided depending on the level of glomerular filtration calculated during isotopic scanning: the study group included children with glomerular hyperfiltration (>200ml/min), the control group included children with normal glomerular filtration rate. Concentration of KIM-1, FGF-23, NAG, NGAL in serum as well as concentration of NGAL and uromoduline in urine was measured in all patients. The results were compared in the above-mentioned groups. In children with renal glomerular hyperfiltration statistically significantly higher serum values of FGF-23 and NGAL were found in comparison to children with normal glomerular filtration rate (p<0,05). There were no statistically significant differences in serum concentrations of the tested markers in children with confirmed scars in the renal parenchyma in the renoscintigraphy compared to children with normal renal image. There were no statistically significant differences in concentration of tested markers in urine. The results of the study indicate the usefulness of FGF-23 and NGAL in monitoring the early stage of renal disease with glomerular hyperfiltration in children." @default.
- W2954069384 created "2019-07-12" @default.
- W2954069384 creator A5018110406 @default.
- W2954069384 creator A5023781295 @default.
- W2954069384 date "2019-07-01" @default.
- W2954069384 modified "2023-09-25" @default.
- W2954069384 title "SAT-177 THE ASSESSMENT OF THE UTILITY OF SELECTED EARLY MARKERS OF CHRONIC KIDNEY DISEASE IN CHILDREN WITH URINARY TRACT DISORDERS SUBJECTED TO RENOSCINTIGRAPHY" @default.
- W2954069384 doi "https://doi.org/10.1016/j.ekir.2019.05.211" @default.
- W2954069384 hasPublicationYear "2019" @default.
- W2954069384 type Work @default.
- W2954069384 sameAs 2954069384 @default.
- W2954069384 citedByCount "0" @default.
- W2954069384 crossrefType "journal-article" @default.
- W2954069384 hasAuthorship W2954069384A5018110406 @default.
- W2954069384 hasAuthorship W2954069384A5023781295 @default.
- W2954069384 hasBestOaLocation W29540693841 @default.
- W2954069384 hasConcept C126322002 @default.
- W2954069384 hasConcept C126894567 @default.
- W2954069384 hasConcept C159641895 @default.
- W2954069384 hasConcept C185592680 @default.
- W2954069384 hasConcept C2776174234 @default.
- W2954069384 hasConcept C2776179406 @default.
- W2954069384 hasConcept C2778653478 @default.
- W2954069384 hasConcept C2779548226 @default.
- W2954069384 hasConcept C2779561371 @default.
- W2954069384 hasConcept C2779922275 @default.
- W2954069384 hasConcept C2780091579 @default.
- W2954069384 hasConcept C2780306776 @default.
- W2954069384 hasConcept C2781197716 @default.
- W2954069384 hasConcept C2908647359 @default.
- W2954069384 hasConcept C55493867 @default.
- W2954069384 hasConcept C71924100 @default.
- W2954069384 hasConcept C74460091 @default.
- W2954069384 hasConcept C77411442 @default.
- W2954069384 hasConcept C99454951 @default.
- W2954069384 hasConceptScore W2954069384C126322002 @default.
- W2954069384 hasConceptScore W2954069384C126894567 @default.
- W2954069384 hasConceptScore W2954069384C159641895 @default.
- W2954069384 hasConceptScore W2954069384C185592680 @default.
- W2954069384 hasConceptScore W2954069384C2776174234 @default.
- W2954069384 hasConceptScore W2954069384C2776179406 @default.
- W2954069384 hasConceptScore W2954069384C2778653478 @default.
- W2954069384 hasConceptScore W2954069384C2779548226 @default.
- W2954069384 hasConceptScore W2954069384C2779561371 @default.
- W2954069384 hasConceptScore W2954069384C2779922275 @default.
- W2954069384 hasConceptScore W2954069384C2780091579 @default.
- W2954069384 hasConceptScore W2954069384C2780306776 @default.
- W2954069384 hasConceptScore W2954069384C2781197716 @default.
- W2954069384 hasConceptScore W2954069384C2908647359 @default.
- W2954069384 hasConceptScore W2954069384C55493867 @default.
- W2954069384 hasConceptScore W2954069384C71924100 @default.
- W2954069384 hasConceptScore W2954069384C74460091 @default.
- W2954069384 hasConceptScore W2954069384C77411442 @default.
- W2954069384 hasConceptScore W2954069384C99454951 @default.
- W2954069384 hasIssue "7" @default.
- W2954069384 hasLocation W29540693841 @default.
- W2954069384 hasOpenAccess W2954069384 @default.
- W2954069384 hasPrimaryLocation W29540693841 @default.
- W2954069384 hasRelatedWork W2042710484 @default.
- W2954069384 hasRelatedWork W2053422287 @default.
- W2954069384 hasRelatedWork W2124543160 @default.
- W2954069384 hasRelatedWork W2124955738 @default.
- W2954069384 hasRelatedWork W2180564022 @default.
- W2954069384 hasRelatedWork W3021673416 @default.
- W2954069384 hasRelatedWork W3132812123 @default.
- W2954069384 hasRelatedWork W3148712325 @default.
- W2954069384 hasRelatedWork W4243973908 @default.
- W2954069384 hasRelatedWork W593504957 @default.
- W2954069384 hasVolume "4" @default.
- W2954069384 isParatext "false" @default.
- W2954069384 isRetracted "false" @default.
- W2954069384 magId "2954069384" @default.
- W2954069384 workType "article" @default.