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- W295408030 abstract "Previously we reported that the GPX1 overexpressing mice (OE) developed a metabolic syndrome-like phenotype at 6-months of age. Subsequent characterization illustrated hyperinsulinemia as the primary effect of GPX1 overproduction. The objective of this study was to determine if the long-term obesity and insulin resistance led to overt type 2 diabetes at old age. Five OE and wild-type (WT) mice each were fed a Se-adequate diet until 1 year of age and used for glucose and insulin analysis. Compared with the WT, the OE mice were 44% heavier (36.0 ± 4.2 vs. 51.9 ± 3.8 g, P < 0.05), had 5-fold greater fasting plasma insulin concentration (0.21 ± 0.13 vs. 1.45 ± 0.33 ng/ml, P< 0.05), showed 50% less plasma glucose decrease (P < 0.05) at 30, 60, and 240 min after an injection of insulin (1 U/kg), and secreted 4 to 8 times more (P < 0.05) insulin at 15, 30, and 60 min after an injection of glucose (2 g/kg). However, the old OE mice exhibited only mild fasting hyperglycemia (100 ± 15 vs.144 ± 20 mg/dl) and improved glucose clearance, without glucosuria. In conclusion, the old OE mice seemed to be a novel obesity model that might be resistant to the development of overt type 2 diabetes (NIH DK53018)." @default.
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- W295408030 date "2009-04-01" @default.
- W295408030 modified "2023-09-27" @default.
- W295408030 title "Old obese GPX1 overexpressing mice do not develop overt type 2 diabetes" @default.
- W295408030 doi "https://doi.org/10.1096/fasebj.23.1_supplement.338.4" @default.
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