FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954080470> ?p ?o ?g. }

• W2954080470 endingPage "1479" @default.
• W2954080470 startingPage "1469" @default.
• W2954080470 abstract "Abstract Aberrant loss of tumor‐suppressor genes plays a crucial role in tumorigenesis and development of colorectal cancer (CRC). Extensive studies have reported tha hypermethylation of Ras association domain family member 6 (RASSF6) is common in various solid tumors. Another important mode of epigenetic regulation, microRNA (miRNA) regulation of RASSF6, is far from clear. The aim of the present work was to screen out novel miRNA regulating RASSF6, and to explore its underlying mechanism in CRC. With the use of bioinformatics, clinical sample data, and luciferase binding assay, we determined that microRNA‐496 (miR‐496) could be a novel oncomiR that directly binds to RASSF6. Next, a series of miR‐496 mimics or inhibitor, or RASSF6 small interfering RNA (siRNA) introduced into CRC cells were applied to examine the effect of miR‐496 on CRC cell viability, migration, and epithelial‐mesenchymal transition (EMT). The results demonstrated that miR‐496/RASSF6 could promote cell migration and EMT via Wnt signaling activation, but had no effect on cell viability. Our results confirmed that the miR‐496/RASSF6 axis is involved in Wnt pathway‐mediated tumor metastasis, highlighting its potential as a therapeutic target for CRC." @default.
• W2954080470 created "2019-07-12" @default.
• W2954080470 creator A5017083884 @default.
• W2954080470 creator A5017899711 @default.
• W2954080470 creator A5020615499 @default.
• W2954080470 creator A5027090738 @default.
• W2954080470 creator A5053725057 @default.
• W2954080470 creator A5076014156 @default.
• W2954080470 creator A5085242835 @default.
• W2954080470 creator A5088858663 @default.
• W2954080470 date "2019-07-04" @default.
• W2954080470 modified "2023-10-17" @default.
• W2954080470 title "MiR‐496 promotes migration and epithelial‐mesenchymal transition by targeting RASSF6 in colorectal cancer" @default.
• W2954080470 cites W1980385207 @default.
• W2954080470 cites W1998484183 @default.
• W2954080470 cites W2004339436 @default.
• W2954080470 cites W2049812522 @default.
• W2954080470 cites W2058693339 @default.
• W2954080470 cites W2115014783 @default.
• W2954080470 cites W2115792588 @default.
• W2954080470 cites W2139992910 @default.
• W2954080470 cites W2173293677 @default.
• W2954080470 cites W2191616177 @default.
• W2954080470 cites W2272984102 @default.
• W2954080470 cites W2335789248 @default.
• W2954080470 cites W2336674565 @default.
• W2954080470 cites W2395024433 @default.
• W2954080470 cites W2563941098 @default.
• W2954080470 cites W2735555398 @default.
• W2954080470 cites W2779263916 @default.
• W2954080470 cites W2779372229 @default.
• W2954080470 cites W2795549746 @default.
• W2954080470 cites W2808935360 @default.
• W2954080470 cites W2883038666 @default.
• W2954080470 cites W2883184095 @default.
• W2954080470 cites W2885571568 @default.
• W2954080470 cites W2895877601 @default.
• W2954080470 cites W2905949588 @default.
• W2954080470 doi "https://doi.org/10.1002/jcp.29066" @default.
• W2954080470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31273789" @default.
• W2954080470 hasPublicationYear "2019" @default.
• W2954080470 type Work @default.
• W2954080470 sameAs 2954080470 @default.
• W2954080470 citedByCount "30" @default.
• W2954080470 countsByYear W29540804702019 @default.
• W2954080470 countsByYear W29540804702020 @default.
• W2954080470 countsByYear W29540804702021 @default.
• W2954080470 countsByYear W29540804702022 @default.
• W2954080470 countsByYear W29540804702023 @default.
• W2954080470 crossrefType "journal-article" @default.
• W2954080470 hasAuthorship W2954080470A5017083884 @default.
• W2954080470 hasAuthorship W2954080470A5017899711 @default.
• W2954080470 hasAuthorship W2954080470A5020615499 @default.
• W2954080470 hasAuthorship W2954080470A5027090738 @default.
• W2954080470 hasAuthorship W2954080470A5053725057 @default.
• W2954080470 hasAuthorship W2954080470A5076014156 @default.
• W2954080470 hasAuthorship W2954080470A5085242835 @default.
• W2954080470 hasAuthorship W2954080470A5088858663 @default.
• W2954080470 hasConcept C104317684 @default.
• W2954080470 hasConcept C121608353 @default.
• W2954080470 hasConcept C137620995 @default.
• W2954080470 hasConcept C145059251 @default.
• W2954080470 hasConcept C179185449 @default.
• W2954080470 hasConcept C2779013556 @default.
• W2954080470 hasConcept C41091548 @default.
• W2954080470 hasConcept C502942594 @default.
• W2954080470 hasConcept C526805850 @default.
• W2954080470 hasConcept C54355233 @default.
• W2954080470 hasConcept C555283112 @default.
• W2954080470 hasConcept C60365752 @default.
• W2954080470 hasConcept C62203573 @default.
• W2954080470 hasConcept C62478195 @default.
• W2954080470 hasConcept C67705224 @default.
• W2954080470 hasConcept C76419328 @default.
• W2954080470 hasConcept C86803240 @default.
• W2954080470 hasConcept C95444343 @default.
• W2954080470 hasConceptScore W2954080470C104317684 @default.
• W2954080470 hasConceptScore W2954080470C121608353 @default.
• W2954080470 hasConceptScore W2954080470C137620995 @default.
• W2954080470 hasConceptScore W2954080470C145059251 @default.
• W2954080470 hasConceptScore W2954080470C179185449 @default.
• W2954080470 hasConceptScore W2954080470C2779013556 @default.
• W2954080470 hasConceptScore W2954080470C41091548 @default.
• W2954080470 hasConceptScore W2954080470C502942594 @default.
• W2954080470 hasConceptScore W2954080470C526805850 @default.
• W2954080470 hasConceptScore W2954080470C54355233 @default.
• W2954080470 hasConceptScore W2954080470C555283112 @default.
• W2954080470 hasConceptScore W2954080470C60365752 @default.
• W2954080470 hasConceptScore W2954080470C62203573 @default.
• W2954080470 hasConceptScore W2954080470C62478195 @default.
• W2954080470 hasConceptScore W2954080470C67705224 @default.
• W2954080470 hasConceptScore W2954080470C76419328 @default.
• W2954080470 hasConceptScore W2954080470C86803240 @default.
• W2954080470 hasConceptScore W2954080470C95444343 @default.
• W2954080470 hasIssue "2" @default.
• W2954080470 hasLocation W29540804701 @default.
• W2954080470 hasLocation W29540804702 @default.
• W2954080470 hasOpenAccess W2954080470 @default.

• next