Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954087010> ?p ?o ?g. }
- W2954087010 endingPage "2513" @default.
- W2954087010 startingPage "2492" @default.
- W2954087010 abstract "The spatial organization of the genome is enigmatic. Direct evidence of physical contacts between chromosomes and their visualization at nanoscale resolution has been limited. We used superresolution microscopy to demonstrate that ribosomal DNA (rDNA) can form linkages between chromosomes. We observed rDNA linkages in many different human cell types and demonstrated their resolution in anaphase. rDNA linkages are coated by the transcription factor UBF and their formation depends on UBF, indicating that they regularly occur between transcriptionally active loci. Overexpression of c-Myc increases rDNA transcription and the frequency of rDNA linkages, further suggesting that their formation depends on active transcription. Linkages persist in the absence of cohesion, but inhibition of topoisomerase II prevents their resolution in anaphase. We propose that linkages are topological intertwines occurring between transcriptionally active rDNA loci spatially colocated in the same nucleolar compartment. Our findings suggest that active DNA loci engage in physical interchromosomal connections that are an integral and pervasive feature of genome organization." @default.
- W2954087010 created "2019-07-12" @default.
- W2954087010 creator A5008688636 @default.
- W2954087010 creator A5016119539 @default.
- W2954087010 creator A5017521861 @default.
- W2954087010 creator A5031265292 @default.
- W2954087010 creator A5033229097 @default.
- W2954087010 creator A5033459990 @default.
- W2954087010 creator A5067830488 @default.
- W2954087010 date "2019-07-03" @default.
- W2954087010 modified "2023-10-12" @default.
- W2954087010 title "Superresolution microscopy reveals linkages between ribosomal DNA on heterologous chromosomes" @default.
- W2954087010 cites W1505408219 @default.
- W2954087010 cites W1551874820 @default.
- W2954087010 cites W158943628 @default.
- W2954087010 cites W1638194466 @default.
- W2954087010 cites W1848563179 @default.
- W2954087010 cites W1916421631 @default.
- W2954087010 cites W1963884797 @default.
- W2954087010 cites W1972778166 @default.
- W2954087010 cites W1972863838 @default.
- W2954087010 cites W1977961184 @default.
- W2954087010 cites W1979353111 @default.
- W2954087010 cites W1979401608 @default.
- W2954087010 cites W1982399647 @default.
- W2954087010 cites W1984479378 @default.
- W2954087010 cites W1994680231 @default.
- W2954087010 cites W2002263141 @default.
- W2954087010 cites W2006981649 @default.
- W2954087010 cites W2009356080 @default.
- W2954087010 cites W2018388970 @default.
- W2954087010 cites W2021764678 @default.
- W2954087010 cites W2037228253 @default.
- W2954087010 cites W2037875706 @default.
- W2954087010 cites W2038752369 @default.
- W2954087010 cites W2050788953 @default.
- W2954087010 cites W2050915272 @default.
- W2954087010 cites W2064038671 @default.
- W2954087010 cites W2064782430 @default.
- W2954087010 cites W2067325456 @default.
- W2954087010 cites W2072980043 @default.
- W2954087010 cites W2073031672 @default.
- W2954087010 cites W2080615813 @default.
- W2954087010 cites W2081211504 @default.
- W2954087010 cites W2083103029 @default.
- W2954087010 cites W2083483319 @default.
- W2954087010 cites W2092499706 @default.
- W2954087010 cites W2106320156 @default.
- W2954087010 cites W2107277218 @default.
- W2954087010 cites W2108194932 @default.
- W2954087010 cites W2114591008 @default.
- W2954087010 cites W2114800213 @default.
- W2954087010 cites W2114979281 @default.
- W2954087010 cites W2115737236 @default.
- W2954087010 cites W2116541338 @default.
- W2954087010 cites W2118483219 @default.
- W2954087010 cites W2121413649 @default.
- W2954087010 cites W2122077019 @default.
- W2954087010 cites W2123355529 @default.
- W2954087010 cites W2128677827 @default.
- W2954087010 cites W2131823236 @default.
- W2954087010 cites W2136817553 @default.
- W2954087010 cites W2138237282 @default.
- W2954087010 cites W2140561448 @default.
- W2954087010 cites W2143493955 @default.
- W2954087010 cites W2145802624 @default.
- W2954087010 cites W2147804306 @default.
- W2954087010 cites W2149241780 @default.
- W2954087010 cites W2150470497 @default.
- W2954087010 cites W2151757310 @default.
- W2954087010 cites W2152242262 @default.
- W2954087010 cites W2158441437 @default.
- W2954087010 cites W2158603579 @default.
- W2954087010 cites W2185201703 @default.
- W2954087010 cites W2188730338 @default.
- W2954087010 cites W2192080449 @default.
- W2954087010 cites W2269415927 @default.
- W2954087010 cites W2320565618 @default.
- W2954087010 cites W2410580121 @default.
- W2954087010 cites W2412089407 @default.
- W2954087010 cites W2417181772 @default.
- W2954087010 cites W2476271072 @default.
- W2954087010 cites W2516096734 @default.
- W2954087010 cites W2523410070 @default.
- W2954087010 cites W2529592315 @default.
- W2954087010 cites W2691619554 @default.
- W2954087010 cites W2694636033 @default.
- W2954087010 cites W2734388176 @default.
- W2954087010 cites W2767575105 @default.
- W2954087010 cites W2768303680 @default.
- W2954087010 cites W2793070095 @default.
- W2954087010 cites W4235139267 @default.
- W2954087010 doi "https://doi.org/10.1083/jcb.201810166" @default.
- W2954087010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6683752" @default.
- W2954087010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31270138" @default.
- W2954087010 hasPublicationYear "2019" @default.
- W2954087010 type Work @default.
- W2954087010 sameAs 2954087010 @default.