Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954111370> ?p ?o ?g. }
- W2954111370 abstract "Abstract Exogenous metabolites from microbial and dietary origins have profound effects on host metabolism. Here, we report that a sub-population of lipid droplets (LDs), which are conserved organelles for fat storage, is defined by metabolite-modulated targeting of the C. elegans seipin ortholog, SEIP-1. Loss of SEIP-1 function reduces the size of a subset of LDs while over-expression of SEIP-1 has the opposite effect. Ultrastructural analysis reveals SEIP-1 enrichment in an endoplasmic reticulum (ER) subdomain, which co-purifies with LDs. Analyses of C. elegans and bacterial genetic mutants indicate a requirement of polyunsaturated fatty acids (PUFAs) and microbial cyclopropane fatty acids (CFAs) for SEIP-1 enrichment, as confirmed by dietary supplementation experiments. In mammalian cells, heterologously expressed SEIP-1 engages nascent lipid droplets and promotes their subsequent expansion in a conserved manner. Our results suggest that microbial and polyunsaturated fatty acids serve unexpected roles in regulating cellular fat storage by promoting LD diversity." @default.
- W2954111370 created "2019-07-12" @default.
- W2954111370 creator A5003347576 @default.
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- W2954111370 date "2019-07-01" @default.
- W2954111370 modified "2023-10-06" @default.
- W2954111370 title "Dietary fatty acids promote lipid droplet diversity through seipin enrichment in an ER subdomain" @default.
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