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- W2954130923 abstract "New World (NW) arenaviruses are a diverse family of emerging zoonotic viruses that merit significant attention as important public health problems. The close genetic relationship of nonpathogenic NW arenaviruses with their highly pathogenic cousins suggests that few mutations may be sufficient to enhance virulence. The identification of molecular determinants of virulence of NW arenaviruses is therefore of great importance. Here we undertook a side-by-side comparison of the innate immune responses against the highly pathogenic Junin virus (JUNV) and the related nonpathogenic Tacaribe virus (TCRV) in human cells. We consistently found that TCRV induces a stronger type I interferon (IFN-I) response than JUNV. Transcriptome profiling revealed an overlapping pattern of IFN-induced gene expression and similar low sensitivities to IFN-I treatment. However, the double-stranded RNA (dsRNA)-dependent protein kinase R (PKR) contributed to the control of TCRV, but not JUNV, providing the first evidence for differential innate recognition and control of JUNV and TCRV." @default.
- W2954130923 created "2019-07-12" @default.
- W2954130923 creator A5000327534 @default.
- W2954130923 creator A5011303680 @default.
- W2954130923 creator A5012038468 @default.
- W2954130923 creator A5036383920 @default.
- W2954130923 creator A5064923292 @default.
- W2954130923 date "2019-10-01" @default.
- W2954130923 modified "2023-10-18" @default.
- W2954130923 title "Comparison of the Innate Immune Responses to Pathogenic and Nonpathogenic Clade B New World Arenaviruses" @default.
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