Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954133033> ?p ?o ?g. }
- W2954133033 endingPage "919" @default.
- W2954133033 startingPage "913" @default.
- W2954133033 abstract "Pancreatic cancer (PDAC) with localized stage includes resectable (RPC), borderline resectable (BRPC), or locally advanced unresectable (LAPC). Standard of care for RPC is adjuvant chemotherapy. There are no prospective randomized trials for best treatment of BRPC and LAPC. We evaluate the impact of induction chemotherapy on localized PDAC.Charts of PDAC patients treated at Emory University between 2009 and 2016 were reviewed. The primary end point was overall survival (OS).A total of 409 localized PDACs were identified. Resectability was prospectively determined at a multidisciplinary tumor conference. Median age was 67 years (range, 30-92 years), 49% were male, 66% were white, 171 had RPC, 131 had BRPC, and 107 had LAPC. Median OSs for RPC, BRPC, and LAPC were 19.5, 16.1, and 12.7 months, respectively. Type of chemotherapy and age were predictors of OS. Induction chemotherapy was used in 106 with BRPC (81%) and 74 with RPC (56.5%); patients with BRPC who received combination chemotherapy and resection had a median OS of 31.5 compared with 19.5 months in patients with RPC (P = 0.0049). Patients with LAPC had a median OS of 12.7 months.In patients with BRPC who undergo resection after induction treatment, the OS was significantly better than in patients with RPC. Neoadjuvant treatment should be considered for all localized PDACs." @default.
- W2954133033 created "2019-07-12" @default.
- W2954133033 creator A5025036628 @default.
- W2954133033 creator A5025524746 @default.
- W2954133033 creator A5027872333 @default.
- W2954133033 creator A5029089899 @default.
- W2954133033 creator A5034318734 @default.
- W2954133033 creator A5040346817 @default.
- W2954133033 creator A5041204638 @default.
- W2954133033 creator A5046255337 @default.
- W2954133033 creator A5047220835 @default.
- W2954133033 creator A5057176768 @default.
- W2954133033 creator A5061782206 @default.
- W2954133033 creator A5064900192 @default.
- W2954133033 creator A5078652492 @default.
- W2954133033 creator A5089966579 @default.
- W2954133033 date "2019-07-02" @default.
- W2954133033 modified "2023-10-01" @default.
- W2954133033 title "Induction Therapy in Localized Pancreatic Cancer" @default.
- W2954133033 cites W1990383064 @default.
- W2954133033 cites W1992458280 @default.
- W2954133033 cites W2005127510 @default.
- W2954133033 cites W2013507617 @default.
- W2954133033 cites W2022501291 @default.
- W2954133033 cites W2054625398 @default.
- W2954133033 cites W2079753351 @default.
- W2954133033 cites W2079934168 @default.
- W2954133033 cites W2092083235 @default.
- W2954133033 cites W2138582833 @default.
- W2954133033 cites W2151253787 @default.
- W2954133033 cites W2165480504 @default.
- W2954133033 cites W2167628315 @default.
- W2954133033 cites W2171950337 @default.
- W2954133033 cites W2176024655 @default.
- W2954133033 cites W2264945221 @default.
- W2954133033 cites W2332844714 @default.
- W2954133033 cites W2345822778 @default.
- W2954133033 cites W2403094648 @default.
- W2954133033 cites W2581973599 @default.
- W2954133033 cites W2598492433 @default.
- W2954133033 cites W2737789729 @default.
- W2954133033 cites W2791666791 @default.
- W2954133033 cites W2805624157 @default.
- W2954133033 cites W2807081886 @default.
- W2954133033 cites W2889751734 @default.
- W2954133033 cites W4247785462 @default.
- W2954133033 doi "https://doi.org/10.1097/mpa.0000000000001353" @default.
- W2954133033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31268982" @default.
- W2954133033 hasPublicationYear "2019" @default.
- W2954133033 type Work @default.
- W2954133033 sameAs 2954133033 @default.
- W2954133033 citedByCount "7" @default.
- W2954133033 countsByYear W29541330332020 @default.
- W2954133033 countsByYear W29541330332021 @default.
- W2954133033 countsByYear W29541330332022 @default.
- W2954133033 countsByYear W29541330332023 @default.
- W2954133033 crossrefType "journal-article" @default.
- W2954133033 hasAuthorship W2954133033A5025036628 @default.
- W2954133033 hasAuthorship W2954133033A5025524746 @default.
- W2954133033 hasAuthorship W2954133033A5027872333 @default.
- W2954133033 hasAuthorship W2954133033A5029089899 @default.
- W2954133033 hasAuthorship W2954133033A5034318734 @default.
- W2954133033 hasAuthorship W2954133033A5040346817 @default.
- W2954133033 hasAuthorship W2954133033A5041204638 @default.
- W2954133033 hasAuthorship W2954133033A5046255337 @default.
- W2954133033 hasAuthorship W2954133033A5047220835 @default.
- W2954133033 hasAuthorship W2954133033A5057176768 @default.
- W2954133033 hasAuthorship W2954133033A5061782206 @default.
- W2954133033 hasAuthorship W2954133033A5064900192 @default.
- W2954133033 hasAuthorship W2954133033A5078652492 @default.
- W2954133033 hasAuthorship W2954133033A5089966579 @default.
- W2954133033 hasConcept C121608353 @default.
- W2954133033 hasConcept C126322002 @default.
- W2954133033 hasConcept C143998085 @default.
- W2954133033 hasConcept C146357865 @default.
- W2954133033 hasConcept C151730666 @default.
- W2954133033 hasConcept C2776611710 @default.
- W2954133033 hasConcept C2776694085 @default.
- W2954133033 hasConcept C2780210213 @default.
- W2954133033 hasConcept C71924100 @default.
- W2954133033 hasConcept C86803240 @default.
- W2954133033 hasConceptScore W2954133033C121608353 @default.
- W2954133033 hasConceptScore W2954133033C126322002 @default.
- W2954133033 hasConceptScore W2954133033C143998085 @default.
- W2954133033 hasConceptScore W2954133033C146357865 @default.
- W2954133033 hasConceptScore W2954133033C151730666 @default.
- W2954133033 hasConceptScore W2954133033C2776611710 @default.
- W2954133033 hasConceptScore W2954133033C2776694085 @default.
- W2954133033 hasConceptScore W2954133033C2780210213 @default.
- W2954133033 hasConceptScore W2954133033C71924100 @default.
- W2954133033 hasConceptScore W2954133033C86803240 @default.
- W2954133033 hasIssue "7" @default.
- W2954133033 hasLocation W29541330331 @default.
- W2954133033 hasLocation W29541330332 @default.
- W2954133033 hasOpenAccess W2954133033 @default.
- W2954133033 hasPrimaryLocation W29541330331 @default.
- W2954133033 hasRelatedWork W1561150073 @default.
- W2954133033 hasRelatedWork W167319750 @default.