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• W2954144423 endingPage "58" @default.
• W2954144423 startingPage "58" @default.
• W2954144423 abstract "Candida auris is an emerging multidrug-resistant yeast first described in 2009 that has since caused healthcare-associated outbreaks of severe human infections around the world. In some hospitals, it has become a leading cause of invasive candidiasis. C. auris is markedly different from most other pathogenic Candida species in its genetics, antifungal resistance, and ability to spread between patients. The reasons why this fungus began spreading widely in the last decade remain a mystery. We examine available data on C. auris and related species, including genomic epidemiology, phenotypic characteristics, and sites of detection, to put forth hypotheses on its possible origins. C. auris has not been detected in the natural environment; related species have been detected in in plants, insects, and aquatic environments, as well as from human body sites. It can tolerate hypersaline environments and higher temperatures than most Candida species. We explore hypotheses about the pre-emergence niche of C. auris, whether in the environmental or human microbiome, and speculate on factors that might have led to its spread, including the possible roles of healthcare, antifungal use, and environmental changes, including human activities that might have expanded its presence in the environment or caused increased human contact." @default.
• W2954144423 created "2019-07-12" @default.
• W2954144423 creator A5008885135 @default.
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• W2954144423 creator A5060071132 @default.
• W2954144423 creator A5072347654 @default.
• W2954144423 creator A5089720853 @default.
• W2954144423 date "2019-07-06" @default.
• W2954144423 modified "2023-10-16" @default.
• W2954144423 title "On the Origins of a Species: What Might Explain the Rise of Candida auris?" @default.
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• W2954144423 doi "https://doi.org/10.3390/jof5030058" @default.
• W2954144423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6787658" @default.
• W2954144423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31284576" @default.
• W2954144423 hasPublicationYear "2019" @default.
• W2954144423 type Work @default.

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