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- W2954146522 abstract "Biofilm formation is one of the resistance mechanisms of Pseudomonas aeruginosa against antimicrobial compounds. Biofilm formation also characterizes for the infection and pathogenesis of P. aeruginosa, along with production of various virulence factors. With recent development of nanotechnology, the present study aims to employ the synthetic iron nanoparticle (FeOOH-NP) as an active agent to inhibit the formation of P. aeruginosa biofilm. The FeOOH-NP was synthesized and characterized with rod shape and average size of 40 nm. Inhibition of biofilm formation by the FeOOH-NP is in a concentration-dependent manner, with inhibition of biofilm formation increased as the FeOOH-NP concentration increased. Microscopic observations also confirmed the disruption of the biofilm architecture in the presence of the FeOOH-NP. In addition, the presence of the FeOOH-NP was also found to modulate bacterial motility as well as some other important virulence factors produced simultaneously with biofilm formation. These findings provide insights to anti-biofilm effect of a new iron NP, contributing to the search for an effective agent to combat P. aeruginosa infections resulted from biofilm formation." @default.
- W2954146522 created "2019-07-12" @default.
- W2954146522 creator A5016264590 @default.
- W2954146522 creator A5042787491 @default.
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- W2954146522 creator A5078915948 @default.
- W2954146522 creator A5086765317 @default.
- W2954146522 creator A5088583277 @default.
- W2954146522 date "2019-06-27" @default.
- W2954146522 modified "2023-10-14" @default.
- W2954146522 title "Biofilm inhibition, modulation of virulence and motility properties by FeOOH nanoparticle in Pseudomonas aeruginosa" @default.
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- W2954146522 doi "https://doi.org/10.1007/s42770-019-00108-z" @default.
- W2954146522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6863290" @default.
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- W2954146522 hasPublicationYear "2019" @default.
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