FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954160980> ?p ?o ?g. }

• W2954160980 endingPage "3134" @default.
• W2954160980 startingPage "3134" @default.
• W2954160980 abstract "Since many oncogenes, including BCR-ABL, may promote the acquisition and maintenance of the glycolytic phenotype, we tested whether treatment of BCR-ABL-driven human leukemia cells with imatinib, a selective BCR-ABL inhibitor, can modulate the expression of key glycolytic enzymes and mitochondrial complex subunits thus causing alterations of glucose metabolism. BCR-ABL-driven K562 and KCL-22 cells were incubated with increasing concentrations of imatinib to preliminarily test drug sensitivity. Then untreated and treated cells were analyzed for levels of BCR-ABL signaling mediators and key proteins of glycolytic cascade and oxidative phosphorylation. Effective inhibition of BCR-ABL caused a concomitant reduction of p-ERK1/2, p-AKT, phosphorylated form of STAT3 (at Tyr705 and Ser727), c-Myc and cyclin D1 along with an increase of cleaved PARP and caspase 3 at 48 h after treatment. Furthermore, a strong reduction of the hexokinase II (HKII), phosphorylated form of PKM2 (at Tyr105 and Ser37) and lactate dehydrogenase A (LDH-A) was observed in response to imatinib along with a strong upregulation of mitochondrial complexes (OXPHOS). According to these findings, a significant reduction of glucose consumption and lactate secretion along with an increase of intracellular ATP levels was observed in response to imatinib. Our findings indicate that imatinib treatment of BCR-ABL-driven human leukemia cells reactivates mitochondrial oxidative phosphorylation thus allowing potential co-targeting of BCR-ABL and OXPHOS." @default.
• W2954160980 created "2019-07-12" @default.
• W2954160980 creator A5009252844 @default.
• W2954160980 creator A5049072084 @default.
• W2954160980 creator A5057946202 @default.
• W2954160980 creator A5060413805 @default.
• W2954160980 creator A5064673445 @default.
• W2954160980 creator A5078017458 @default.
• W2954160980 date "2019-06-27" @default.
• W2954160980 modified "2023-10-09" @default.
• W2954160980 title "Coordinate Modulation of Glycolytic Enzymes and OXPHOS by Imatinib in BCR-ABL Driven Chronic Myelogenous Leukemia Cells" @default.
• W2954160980 cites W1969836970 @default.
• W2954160980 cites W1982218359 @default.
• W2954160980 cites W1995444593 @default.
• W2954160980 cites W2012828386 @default.
• W2954160980 cites W2015207840 @default.
• W2954160980 cites W2021413430 @default.
• W2954160980 cites W2054334049 @default.
• W2954160980 cites W2086344594 @default.
• W2954160980 cites W2100260504 @default.
• W2954160980 cites W2125490827 @default.
• W2954160980 cites W2136238497 @default.
• W2954160980 cites W2145678539 @default.
• W2954160980 cites W2154297950 @default.
• W2954160980 cites W2164689218 @default.
• W2954160980 cites W2167275598 @default.
• W2954160980 cites W2329648702 @default.
• W2954160980 cites W2553644640 @default.
• W2954160980 cites W2586770430 @default.
• W2954160980 cites W2791252431 @default.
• W2954160980 doi "https://doi.org/10.3390/ijms20133134" @default.
• W2954160980 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6651622" @default.
• W2954160980 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31252559" @default.
• W2954160980 hasPublicationYear "2019" @default.
• W2954160980 type Work @default.
• W2954160980 sameAs 2954160980 @default.
• W2954160980 citedByCount "18" @default.
• W2954160980 countsByYear W29541609802019 @default.
• W2954160980 countsByYear W29541609802020 @default.
• W2954160980 countsByYear W29541609802021 @default.
• W2954160980 countsByYear W29541609802022 @default.
• W2954160980 countsByYear W29541609802023 @default.
• W2954160980 crossrefType "journal-article" @default.
• W2954160980 hasAuthorship W2954160980A5009252844 @default.
• W2954160980 hasAuthorship W2954160980A5049072084 @default.
• W2954160980 hasAuthorship W2954160980A5057946202 @default.
• W2954160980 hasAuthorship W2954160980A5060413805 @default.
• W2954160980 hasAuthorship W2954160980A5064673445 @default.
• W2954160980 hasAuthorship W2954160980A5078017458 @default.
• W2954160980 hasBestOaLocation W29541609801 @default.
• W2954160980 hasConcept C125418893 @default.
• W2954160980 hasConcept C170493617 @default.
• W2954160980 hasConcept C171122931 @default.
• W2954160980 hasConcept C181199279 @default.
• W2954160980 hasConcept C185592680 @default.
• W2954160980 hasConcept C20251656 @default.
• W2954160980 hasConcept C203014093 @default.
• W2954160980 hasConcept C2776960273 @default.
• W2954160980 hasConcept C2777583451 @default.
• W2954160980 hasConcept C2778461978 @default.
• W2954160980 hasConcept C2778729363 @default.
• W2954160980 hasConcept C2779826832 @default.
• W2954160980 hasConcept C2910680157 @default.
• W2954160980 hasConcept C3019892230 @default.
• W2954160980 hasConcept C42362537 @default.
• W2954160980 hasConcept C43907098 @default.
• W2954160980 hasConcept C502942594 @default.
• W2954160980 hasConcept C55493867 @default.
• W2954160980 hasConcept C57600042 @default.
• W2954160980 hasConcept C62478195 @default.
• W2954160980 hasConcept C86803240 @default.
• W2954160980 hasConcept C95444343 @default.
• W2954160980 hasConceptScore W2954160980C125418893 @default.
• W2954160980 hasConceptScore W2954160980C170493617 @default.
• W2954160980 hasConceptScore W2954160980C171122931 @default.
• W2954160980 hasConceptScore W2954160980C181199279 @default.
• W2954160980 hasConceptScore W2954160980C185592680 @default.
• W2954160980 hasConceptScore W2954160980C20251656 @default.
• W2954160980 hasConceptScore W2954160980C203014093 @default.
• W2954160980 hasConceptScore W2954160980C2776960273 @default.
• W2954160980 hasConceptScore W2954160980C2777583451 @default.
• W2954160980 hasConceptScore W2954160980C2778461978 @default.
• W2954160980 hasConceptScore W2954160980C2778729363 @default.
• W2954160980 hasConceptScore W2954160980C2779826832 @default.
• W2954160980 hasConceptScore W2954160980C2910680157 @default.
• W2954160980 hasConceptScore W2954160980C3019892230 @default.
• W2954160980 hasConceptScore W2954160980C42362537 @default.
• W2954160980 hasConceptScore W2954160980C43907098 @default.
• W2954160980 hasConceptScore W2954160980C502942594 @default.
• W2954160980 hasConceptScore W2954160980C55493867 @default.
• W2954160980 hasConceptScore W2954160980C57600042 @default.
• W2954160980 hasConceptScore W2954160980C62478195 @default.
• W2954160980 hasConceptScore W2954160980C86803240 @default.
• W2954160980 hasConceptScore W2954160980C95444343 @default.
• W2954160980 hasIssue "13" @default.
• W2954160980 hasLocation W29541609801 @default.
• W2954160980 hasLocation W29541609802 @default.
• W2954160980 hasLocation W29541609803 @default.

• next