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• W2954167373 abstract "Abstract Milk fat content is an important criterion for assessing milk quality and is one of the main target traits of dairy cattle breeding. Recent studies have shown the importance of melatonin in regulating lipid metabolism, but the potential effects of melatonin on milk fat synthesis in bovine mammary epithelial cells ( BMEC s) remain unclear. Here, we showed that melatonin supplementation at 10 μmol/L significantly downregulated the mRNA expression of lipid metabolism–related genes and resulted in lower lipid droplet formation and triglyceride accumulation. Moreover, melatonin significantly upregulated melatonin receptor subtype melatonin receptor 1a ( MT 1) gene expression, and the negative effects of melatonin on milk fat synthesis were reversed by treatment with the nonselective MT 1/melatonin receptor subtype melatonin receptor 1b ( MT 2) antagonist. However, a selective MT 2 antagonist did not modify the negative effects of melatonin on milk fat synthesis. In addition, KEGG analysis revealed that melatonin inhibition of milk fat synthesis may occur via the mTOR signaling pathway. Further analysis revealed that melatonin significantly suppressed the activation of the mTOR pathway by restricting the phosphorylation of mTOR , 4E‐ BP 1, and p70S6K, and the inhibition of melatonin on milk fat synthesis was reversed by mTOR activator MHY 1485 in BMEC s. Furthermore, in vivo experiments in Holstein dairy cows showed that exogenous melatonin significantly decreased milk fat concentration. Our data from in vitro and in vivo studies revealed that melatonin suppresses milk fat synthesis by inhibiting the mTOR signaling pathway via the MT 1 receptor in BMEC s. These findings lay a foundation to identify a new potential means for melatonin to modulate the fat content of raw milk in Holstein dairy cows." @default.
• W2954167373 created "2019-07-12" @default.
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• W2954167373 date "2019-07-23" @default.
• W2954167373 modified "2023-10-18" @default.
• W2954167373 title "Melatonin suppresses milk fat synthesis by inhibiting the <scp>mTOR</scp> signaling pathway via the <scp>MT</scp>1 receptor in bovine mammary epithelial cells" @default.
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• W2954167373 doi "https://doi.org/10.1111/jpi.12593" @default.
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