FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954184150> ?p ?o ?g. }

• W2954184150 endingPage "201" @default.
• W2954184150 startingPage "194" @default.
• W2954184150 abstract "Oral carcinoma (OSCC) is one of the most important causes of cancer death worldwide. OSCC cell lines and preclinical rodent models are crucial to addressing the mechanisms of OSCC and helping the development of new therapeutic strategies and interventions. The establishment of murine OSCC cell lines and syngeneic models are necessary to allow concordant investigation of both in vitro and in vivo pathogenesis. In this study, we established two murine tongue squamous cell carcinoma cell lines, designated MTCQ1 and MTCQ2, from 4NQO-induced OSCC using C57BL/6 mice. These cell lines express a variety of epithelial markers but produce only a tiny amount of E-cadherin. The expression of mesenchymal and stemness regulators are evident, and this is associated with the high mobility in these cell lines. MTCQ1 also shows high Ki67 and PCNA expression, and complicated alterations in p53 expression, which may underlie its high clonogenic potential and rapid orthotopic tumor induction. Using the MTCQ1 cell subclone tagged with GFP (MTCQ1-GFP), extensive neck nodal metastasis and lung metastasis were identified by immunostaining and fluorescence imaging. Inhibition of oncogenic miRNAs, particularly miR-134, was able to attenuate the oncogenicity of MTCQ1-GFP. Cisplatin treatment inhibited both in vitro and in vivo growth of MTCQ1-GFP, and it was found to decrease miR-134 expression in this subclone. The anti-PD-L1 treatment enhanced the inhibitory effects of cisplatin against tumorigenesis. This syngeneic preclinical model should help provide valuable mechanistic insights into OSCC, as well as helping with the development of new approaches to treating this disease." @default.
• W2954184150 created "2019-07-12" @default.
• W2954184150 creator A5005811575 @default.
• W2954184150 creator A5038097727 @default.
• W2954184150 creator A5046475025 @default.
• W2954184150 creator A5051622628 @default.
• W2954184150 creator A5054851354 @default.
• W2954184150 date "2019-08-01" @default.
• W2954184150 modified "2023-10-17" @default.
• W2954184150 title "Establishment of syngeneic murine model for oral cancer therapy" @default.
• W2954184150 cites W1498533438 @default.
• W2954184150 cites W1604362135 @default.
• W2954184150 cites W1780018678 @default.
• W2954184150 cites W1950794025 @default.
• W2954184150 cites W1971147829 @default.
• W2954184150 cites W2001150039 @default.
• W2954184150 cites W2010267706 @default.
• W2954184150 cites W2022748596 @default.
• W2954184150 cites W2051308361 @default.
• W2954184150 cites W2054144628 @default.
• W2954184150 cites W2064135765 @default.
• W2954184150 cites W2082304528 @default.
• W2954184150 cites W2091153869 @default.
• W2954184150 cites W2100575330 @default.
• W2954184150 cites W2100629274 @default.
• W2954184150 cites W2134297435 @default.
• W2954184150 cites W2141522277 @default.
• W2954184150 cites W2149008645 @default.
• W2954184150 cites W2151592927 @default.
• W2954184150 cites W2161450478 @default.
• W2954184150 cites W2240026504 @default.
• W2954184150 cites W2401473471 @default.
• W2954184150 cites W2593744895 @default.
• W2954184150 cites W2613898758 @default.
• W2954184150 cites W2750364489 @default.
• W2954184150 cites W2755794599 @default.
• W2954184150 cites W2810049731 @default.
• W2954184150 cites W2887577080 @default.
• W2954184150 cites W2911841653 @default.
• W2954184150 cites W2942667504 @default.
• W2954184150 cites W2944380828 @default.
• W2954184150 doi "https://doi.org/10.1016/j.oraloncology.2019.06.026" @default.
• W2954184150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31345390" @default.
• W2954184150 hasPublicationYear "2019" @default.
• W2954184150 type Work @default.
• W2954184150 sameAs 2954184150 @default.
• W2954184150 citedByCount "15" @default.
• W2954184150 countsByYear W29541841502020 @default.
• W2954184150 countsByYear W29541841502022 @default.
• W2954184150 countsByYear W29541841502023 @default.
• W2954184150 crossrefType "journal-article" @default.
• W2954184150 hasAuthorship W2954184150A5005811575 @default.
• W2954184150 hasAuthorship W2954184150A5038097727 @default.
• W2954184150 hasAuthorship W2954184150A5046475025 @default.
• W2954184150 hasAuthorship W2954184150A5051622628 @default.
• W2954184150 hasAuthorship W2954184150A5054851354 @default.
• W2954184150 hasConcept C104317684 @default.
• W2954184150 hasConcept C117262875 @default.
• W2954184150 hasConcept C121608353 @default.
• W2954184150 hasConcept C145059251 @default.
• W2954184150 hasConcept C207001950 @default.
• W2954184150 hasConcept C2779013556 @default.
• W2954184150 hasConcept C502942594 @default.
• W2954184150 hasConcept C54355233 @default.
• W2954184150 hasConcept C555283112 @default.
• W2954184150 hasConcept C81885089 @default.
• W2954184150 hasConcept C86803240 @default.
• W2954184150 hasConceptScore W2954184150C104317684 @default.
• W2954184150 hasConceptScore W2954184150C117262875 @default.
• W2954184150 hasConceptScore W2954184150C121608353 @default.
• W2954184150 hasConceptScore W2954184150C145059251 @default.
• W2954184150 hasConceptScore W2954184150C207001950 @default.
• W2954184150 hasConceptScore W2954184150C2779013556 @default.
• W2954184150 hasConceptScore W2954184150C502942594 @default.
• W2954184150 hasConceptScore W2954184150C54355233 @default.
• W2954184150 hasConceptScore W2954184150C555283112 @default.
• W2954184150 hasConceptScore W2954184150C81885089 @default.
• W2954184150 hasConceptScore W2954184150C86803240 @default.
• W2954184150 hasFunder F4320322795 @default.
• W2954184150 hasLocation W29541841501 @default.
• W2954184150 hasLocation W29541841502 @default.
• W2954184150 hasOpenAccess W2954184150 @default.
• W2954184150 hasPrimaryLocation W29541841501 @default.
• W2954184150 hasRelatedWork W1988174701 @default.
• W2954184150 hasRelatedWork W2004339436 @default.
• W2954184150 hasRelatedWork W2022458244 @default.
• W2954184150 hasRelatedWork W2034722665 @default.
• W2954184150 hasRelatedWork W2046673025 @default.
• W2954184150 hasRelatedWork W2056443990 @default.
• W2954184150 hasRelatedWork W2113725788 @default.
• W2954184150 hasRelatedWork W2347271642 @default.
• W2954184150 hasRelatedWork W2413364007 @default.
• W2954184150 hasRelatedWork W3144241576 @default.
• W2954184150 hasVolume "95" @default.
• W2954184150 isParatext "false" @default.
• W2954184150 isRetracted "false" @default.
• W2954184150 magId "2954184150" @default.
• W2954184150 workType "article" @default.