FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954194865> ?p ?o ?g. }

• W2954194865 endingPage "3173" @default.
• W2954194865 startingPage "3173" @default.
• W2954194865 abstract "Several studies have demonstrated that metformin (MTF) acts with variable efficiency as an anticancer agent. The pleiotropic anticancer effects of MTF on cancer cells have not been fully explored yet. By interrogating the Gene Expression Omnibus (GEO) for microarray expression data, we identified eight eligible submissions, representing five different studies, that employed various conditions including different cell lines, MTF concentrations, treatment durations, and cellular components. A compilation of the data sets of 13 different conditions contained 443 repeatedly up- and 387 repeatedly down-regulated genes; the majority of these 830 differentially expressed genes (DEGs) were associated with higher MTF concentrations and longer MTF treatment. The most frequently upregulated genes include DNA damage inducible transcript 4 (DDIT4), chromodomain helicase DNA binding protein 2 (CHD2), endoplasmic reticulum to nucleus signaling 1 (ERN1), and growth differentiation factor 15 (GDF15). The most commonly downregulated genes include arrestin domain containing 4 (ARRDC4), and thioredoxin interacting protein (TXNIP). The most significantly (p-value < 0.05, Fisher’s exact test) overrepresented protein class was entitled, nucleic acid binding. Cholesterol biosynthesis and other metabolic pathways were specifically affected by downregulated pathway molecules. In addition, cell cycle pathways were significantly related to the data set. Generated networks were significantly related to, e.g., carbohydrate and lipid metabolism, cancer, cell cycle, and DNA replication, recombination, and repair. A second compilation comprised genes that were at least under one condition up- and in at least another condition down-regulated. Herein, the most frequently deregulated genes include nuclear paraspeckle assembly transcript 1 (NEAT1) and insulin induced gene 1 (INSIG1). The most significantly overrepresented protein classes in this compilation were entitled, nucleic acid binding, ubiquitin-protein ligase, and mRNA processing factor. In conclusion, this study provides a comprehensive list of deregulated genes and biofunctions related to in vitro MTF application and individual responses to different conditions. Biofunctions affected by MTF include, e.g., cholesterol synthesis and other metabolic pathways, cell cycle, and DNA replication, recombination, and repair. These findings can assist in defining the conditions in which MTF exerts additive or synergistic effects in cancer treatment." @default.
• W2954194865 created "2019-07-12" @default.
• W2954194865 creator A5000747807 @default.
• W2954194865 creator A5003960456 @default.
• W2954194865 date "2019-06-28" @default.
• W2954194865 modified "2023-09-25" @default.
• W2954194865 title "Meta-Analysis of Microarray Expression Studies on Metformin in Cancer Cell Lines" @default.
• W2954194865 cites W1883153868 @default.
• W2954194865 cites W1990340849 @default.
• W2954194865 cites W1995069275 @default.
• W2954194865 cites W1995532066 @default.
• W2954194865 cites W2025569306 @default.
• W2954194865 cites W2060078714 @default.
• W2954194865 cites W2071396361 @default.
• W2954194865 cites W2080654617 @default.
• W2954194865 cites W2088469990 @default.
• W2954194865 cites W2094953050 @default.
• W2954194865 cites W2106255153 @default.
• W2954194865 cites W2109488005 @default.
• W2954194865 cites W2116036650 @default.
• W2954194865 cites W2118258530 @default.
• W2954194865 cites W2121173674 @default.
• W2954194865 cites W2122335272 @default.
• W2954194865 cites W2134907909 @default.
• W2954194865 cites W2138226825 @default.
• W2954194865 cites W2146512944 @default.
• W2954194865 cites W2154981570 @default.
• W2954194865 cites W2158217645 @default.
• W2954194865 cites W2158240289 @default.
• W2954194865 cites W2164882663 @default.
• W2954194865 cites W2168453644 @default.
• W2954194865 cites W2169675397 @default.
• W2954194865 cites W2194856154 @default.
• W2954194865 cites W222186390 @default.
• W2954194865 cites W2277130803 @default.
• W2954194865 cites W2283176855 @default.
• W2954194865 cites W2323045903 @default.
• W2954194865 cites W2340898396 @default.
• W2954194865 cites W2345568057 @default.
• W2954194865 cites W2413609923 @default.
• W2954194865 cites W2534268229 @default.
• W2954194865 cites W2559466477 @default.
• W2954194865 cites W2561702225 @default.
• W2954194865 cites W2583018095 @default.
• W2954194865 cites W2605757478 @default.
• W2954194865 cites W2617961052 @default.
• W2954194865 cites W2734671954 @default.
• W2954194865 cites W2752701187 @default.
• W2954194865 cites W2761870610 @default.
• W2954194865 cites W2763871199 @default.
• W2954194865 cites W2771111778 @default.
• W2954194865 cites W2783770364 @default.
• W2954194865 cites W2783939587 @default.
• W2954194865 cites W2786720589 @default.
• W2954194865 cites W2789513217 @default.
• W2954194865 cites W2793788114 @default.
• W2954194865 cites W2795771650 @default.
• W2954194865 cites W2796861241 @default.
• W2954194865 cites W2806173386 @default.
• W2954194865 cites W2807334922 @default.
• W2954194865 cites W2809723455 @default.
• W2954194865 cites W2810293702 @default.
• W2954194865 cites W2884113333 @default.
• W2954194865 cites W2885414463 @default.
• W2954194865 cites W2891277144 @default.
• W2954194865 cites W2891475742 @default.
• W2954194865 cites W2900816654 @default.
• W2954194865 cites W2902150071 @default.
• W2954194865 cites W2915536738 @default.
• W2954194865 cites W4250359879 @default.
• W2954194865 cites W4300749991 @default.
• W2954194865 doi "https://doi.org/10.3390/ijms20133173" @default.
• W2954194865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6650866" @default.
• W2954194865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31261735" @default.
• W2954194865 hasPublicationYear "2019" @default.
• W2954194865 type Work @default.
• W2954194865 sameAs 2954194865 @default.
• W2954194865 citedByCount "8" @default.
• W2954194865 countsByYear W29541948652020 @default.
• W2954194865 countsByYear W29541948652021 @default.
• W2954194865 countsByYear W29541948652022 @default.
• W2954194865 countsByYear W29541948652023 @default.
• W2954194865 crossrefType "journal-article" @default.
• W2954194865 hasAuthorship W2954194865A5000747807 @default.
• W2954194865 hasAuthorship W2954194865A5003960456 @default.
• W2954194865 hasBestOaLocation W29541948651 @default.
• W2954194865 hasConcept C104317684 @default.
• W2954194865 hasConcept C134935766 @default.
• W2954194865 hasConcept C150194340 @default.
• W2954194865 hasConcept C153911025 @default.
• W2954194865 hasConcept C29537977 @default.
• W2954194865 hasConcept C54355233 @default.
• W2954194865 hasConcept C8415881 @default.
• W2954194865 hasConcept C86803240 @default.
• W2954194865 hasConcept C95444343 @default.
• W2954194865 hasConceptScore W2954194865C104317684 @default.
• W2954194865 hasConceptScore W2954194865C134935766 @default.
• W2954194865 hasConceptScore W2954194865C150194340 @default.

• next