FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954203505> ?p ?o ?g. }

• W2954203505 endingPage "105807" @default.
• W2954203505 startingPage "105807" @default.
• W2954203505 abstract "The primary goal of an exploratory oncology clinical trial is to identify an effective drug for further development. To account for tumor indication selection error, multiple tumor indications are often selected for simultaneous testing in a basket trial. In this article, we propose optimal and minimax two-stage basket trial designs for exploratory clinical trials. Inactive tumor indications are pruned in stage 1 and the active tumor indications are pooled at end of stage 2 to assess overall effectiveness of the test drug. The proposed designs explicitly control the type I and type II error rates with closed-form sample size formula. They can be viewed as a natural extension of Simon's optimal and minimax two-stage designs for single arm trials to multi-arm basket trials. A simulation study shows that the proposed design method has desirable operating characteristics as compared to other commonly used design methods for exploratory basket trials." @default.
• W2954203505 created "2019-07-12" @default.
• W2954203505 creator A5008880551 @default.
• W2954203505 creator A5029492518 @default.
• W2954203505 creator A5067331026 @default.
• W2954203505 creator A5074861706 @default.
• W2954203505 creator A5085025467 @default.
• W2954203505 creator A5091003095 @default.
• W2954203505 date "2019-10-01" @default.
• W2954203505 modified "2023-10-16" @default.
• W2954203505 title "Optimal two-stage designs for exploratory basket trials" @default.
• W2954203505 cites W1846586690 @default.
• W2954203505 cites W1965815757 @default.
• W2954203505 cites W2007648830 @default.
• W2954203505 cites W2029409133 @default.
• W2954203505 cites W2040875390 @default.
• W2954203505 cites W2071848682 @default.
• W2954203505 cites W2088695439 @default.
• W2954203505 cites W2092335024 @default.
• W2954203505 cites W2129994551 @default.
• W2954203505 cites W2134318552 @default.
• W2954203505 cites W2216798916 @default.
• W2954203505 cites W2266105780 @default.
• W2954203505 cites W2401455386 @default.
• W2954203505 cites W2410993226 @default.
• W2954203505 cites W2481072071 @default.
• W2954203505 cites W2597858800 @default.
• W2954203505 cites W2624426279 @default.
• W2954203505 cites W2750847244 @default.
• W2954203505 cites W2758592311 @default.
• W2954203505 cites W2763584377 @default.
• W2954203505 cites W2774533844 @default.
• W2954203505 cites W2789555072 @default.
• W2954203505 doi "https://doi.org/10.1016/j.cct.2019.06.021" @default.
• W2954203505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31260789" @default.
• W2954203505 hasPublicationYear "2019" @default.
• W2954203505 type Work @default.
• W2954203505 sameAs 2954203505 @default.
• W2954203505 citedByCount "13" @default.
• W2954203505 countsByYear W29542035052020 @default.
• W2954203505 countsByYear W29542035052021 @default.
• W2954203505 countsByYear W29542035052022 @default.
• W2954203505 countsByYear W29542035052023 @default.
• W2954203505 crossrefType "journal-article" @default.
• W2954203505 hasAuthorship W2954203505A5008880551 @default.
• W2954203505 hasAuthorship W2954203505A5029492518 @default.
• W2954203505 hasAuthorship W2954203505A5067331026 @default.
• W2954203505 hasAuthorship W2954203505A5074861706 @default.
• W2954203505 hasAuthorship W2954203505A5085025467 @default.
• W2954203505 hasAuthorship W2954203505A5091003095 @default.
• W2954203505 hasConcept C105795698 @default.
• W2954203505 hasConcept C126255220 @default.
• W2954203505 hasConcept C126322002 @default.
• W2954203505 hasConcept C129848803 @default.
• W2954203505 hasConcept C144024400 @default.
• W2954203505 hasConcept C146357865 @default.
• W2954203505 hasConcept C148482608 @default.
• W2954203505 hasConcept C149728462 @default.
• W2954203505 hasConcept C151730666 @default.
• W2954203505 hasConcept C19165224 @default.
• W2954203505 hasConcept C19527891 @default.
• W2954203505 hasConcept C2779318504 @default.
• W2954203505 hasConcept C33923547 @default.
• W2954203505 hasConcept C40696583 @default.
• W2954203505 hasConcept C535046627 @default.
• W2954203505 hasConcept C71924100 @default.
• W2954203505 hasConcept C85973986 @default.
• W2954203505 hasConcept C86803240 @default.
• W2954203505 hasConceptScore W2954203505C105795698 @default.
• W2954203505 hasConceptScore W2954203505C126255220 @default.
• W2954203505 hasConceptScore W2954203505C126322002 @default.
• W2954203505 hasConceptScore W2954203505C129848803 @default.
• W2954203505 hasConceptScore W2954203505C144024400 @default.
• W2954203505 hasConceptScore W2954203505C146357865 @default.
• W2954203505 hasConceptScore W2954203505C148482608 @default.
• W2954203505 hasConceptScore W2954203505C149728462 @default.
• W2954203505 hasConceptScore W2954203505C151730666 @default.
• W2954203505 hasConceptScore W2954203505C19165224 @default.
• W2954203505 hasConceptScore W2954203505C19527891 @default.
• W2954203505 hasConceptScore W2954203505C2779318504 @default.
• W2954203505 hasConceptScore W2954203505C33923547 @default.
• W2954203505 hasConceptScore W2954203505C40696583 @default.
• W2954203505 hasConceptScore W2954203505C535046627 @default.
• W2954203505 hasConceptScore W2954203505C71924100 @default.
• W2954203505 hasConceptScore W2954203505C85973986 @default.
• W2954203505 hasConceptScore W2954203505C86803240 @default.
• W2954203505 hasLocation W29542035051 @default.
• W2954203505 hasLocation W29542035052 @default.
• W2954203505 hasOpenAccess W2954203505 @default.
• W2954203505 hasPrimaryLocation W29542035051 @default.
• W2954203505 hasRelatedWork W1983336023 @default.
• W2954203505 hasRelatedWork W2028545055 @default.
• W2954203505 hasRelatedWork W2082770695 @default.
• W2954203505 hasRelatedWork W2084726038 @default.
• W2954203505 hasRelatedWork W2162168145 @default.
• W2954203505 hasRelatedWork W2301701445 @default.
• W2954203505 hasRelatedWork W2752553904 @default.
• W2954203505 hasRelatedWork W2888888819 @default.

• next