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• W2954204036 abstract "HIV neuropathogenesis has been attributed in large measure to neurotoxicity of viral proteins and inflammatory factors produced by infected monocytic cells in the brain. We show here that HIV expression in mouse brain causes lasting memory impairment by a mechanism involving injury to hippocampal synaptodendritic arbors and neuronal function but not overt neuronal loss in the region. Our results mirror the observation of minimal neurodegeneration in cognitively impaired HIV patients on antiretroviral therapy and demonstrate that HIV is nonneurotoxic in certain brain abnormalities that it causes. If neurons comprising the cognition-related networks survive HIV insult, at least for some time, there is a window of opportunity for disease treatment." @default.
• W2954204036 created "2019-07-12" @default.
• W2954204036 creator A5018221928 @default.
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• W2954204036 creator A5091754437 @default.
• W2954204036 date "2019-08-27" @default.
• W2954204036 modified "2023-10-16" @default.
• W2954204036 title "Efficient Expression of HIV in Immunocompetent Mouse Brain Reveals a Novel Nonneurotoxic Viral Function in Hippocampal Synaptodendritic Injury and Memory Impairment" @default.
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• W2954204036 doi "https://doi.org/10.1128/mbio.00591-19" @default.
• W2954204036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6606797" @default.
• W2954204036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31266862" @default.

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