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• W2954204707 endingPage "062029" @default.
• W2954204707 startingPage "062029" @default.
• W2954204707 abstract "Abstract Aerobic glycolysis is commonly used as the main energy source for cancer cell growth. Adenylate kinase 2 (AK2) plays an important role in maintenance of ATP production in the mitochondria. Neoandrographolide in Andrographis paniculata potentially inhibit AK2 activity in silico . This study aimed to investigate the inhibitory effect of A. paniculata extract on proliferation of breast cancer cell line. This experimental laboratory used MCF-7 cell line and A. paniculata plants, which were extracted using the maceration method with 70% ethanol. Neoandrographolide concentration in A. paniculata extract was determined using HPLC. A total 1x10 4 MCF-7 cells were incubated for 24 hours with or without 0.4% (v/v) dimethyl sulfoxide as solvent (SC) or negative control (NC) group. The same amount of MCF-7 cells was treated with A. paniculata extract with 3 different dosages: 222 ppm (AE1), 111 ppm (AE2) and 55.5 ppm (AE3). The inhibition of cell proliferation used the 3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolium bromide (MTT) assay. Data were analyzed using ANOVA and LSD tests with p value <0.05.Ethanol extract of A. paniculata contained 4.43 µM neoandrographolide. The inhibition of MCF-7 cell proliferation was found in AE1 (47.98%) and AE2 (30.50%) groups and was significantly different from the NC group. While the percentage of MCF-7 cell inhibition in the AE1 group differed from NC (p = 0.002) and SC (p = 0.013) groups. Ethanol extract of A. paniculata can inhibit MCF-7 cell proliferation. Further Study is needed to investigate the role of neoandrographolide on inhibition of AK2 activity in MCF-7 cells." @default.
• W2954204707 created "2019-07-12" @default.
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• W2954204707 date "2019-06-01" @default.
• W2954204707 modified "2023-09-24" @default.
• W2954204707 title "The inhibitory effect ofAndrographis paniculataextract on proliferation of breast cancer cell line" @default.
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• W2954204707 doi "https://doi.org/10.1088/1757-899x/546/6/062029" @default.
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