FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954205159> ?p ?o ?g. }

• W2954205159 endingPage "107387" @default.
• W2954205159 startingPage "107387" @default.
• W2954205159 abstract "Cardiovascular disease remains the leading cause of death for both men and women. The observation that premenopausal women are protected from cardiovascular disease relative to age-matched men, and that this protection is lost with menopause, has led to extensive study of the role of sex steroid hormones in the pathogenesis of cardiovascular disease. However, the molecular basis for sex differences in cardiovascular disease is still not fully understood, limiting the ability to tailor therapies to male and female patients. Therefore, there is a growing need to investigate molecular pathways outside of traditional sex hormone signaling to fully understand sex differences in cardiovascular disease. Emerging evidence points to the mineralocorticoid receptor (MR), a steroid hormone receptor activated by the adrenal hormone aldosterone, as one such mediator of cardiovascular disease risk, potentially serving as a sex-dependent link between cardiovascular risk factors and disease. Enhanced activation of the MR by aldosterone is associated with increased risk of cardiovascular disease. Emerging evidence implicates the MR specifically within the endothelial cells lining the blood vessels in mediating some of the sex differences observed in cardiovascular pathology. This review summarizes the available clinical and preclinical literature concerning the role of the MR in the pathophysiology of endothelial dysfunction, hypertension, atherosclerosis, and heart failure, with a special emphasis on sex differences in the role of endothelial-specific MR in these pathologies. The available data regarding the molecular mechanisms by which endothelial-specific MR may contribute to sex differences in cardiovascular disease is also summarized. A paradigm emerges from synthesis of the literature in which endothelial-specific MR regulates vascular function in a sex-dependent manner in response to cardiovascular risk factors to contribute to disease. Limitations in this field include the relative paucity of women in clinical trials and, until recently, the nearly exclusive use of male animals in preclinical investigations. Enhanced understanding of the sex-specific roles of endothelial MR could lead to novel mechanistic insights underlying sex differences in cardiovascular disease incidence and outcomes and could identify additional therapeutic targets to effectively treat cardiovascular disease in men and women." @default.
• W2954205159 created "2019-07-12" @default.
• W2954205159 creator A5015102832 @default.
• W2954205159 creator A5019853698 @default.
• W2954205159 creator A5038018721 @default.
• W2954205159 date "2019-11-01" @default.
• W2954205159 modified "2023-10-18" @default.
• W2954205159 title "The endothelial mineralocorticoid receptor: Contributions to sex differences in cardiovascular disease" @default.
• W2954205159 cites W1571027240 @default.
• W2954205159 cites W1744019794 @default.
• W2954205159 cites W1818378016 @default.
• W2954205159 cites W1872613035 @default.
• W2954205159 cites W1940950287 @default.
• W2954205159 cites W1951373717 @default.
• W2954205159 cites W1953196136 @default.
• W2954205159 cites W1958022600 @default.
• W2954205159 cites W1964626513 @default.
• W2954205159 cites W1964702657 @default.
• W2954205159 cites W1965301500 @default.
• W2954205159 cites W1968663020 @default.
• W2954205159 cites W1968999388 @default.
• W2954205159 cites W1969889097 @default.
• W2954205159 cites W1977038176 @default.
• W2954205159 cites W1983323298 @default.
• W2954205159 cites W1985006642 @default.
• W2954205159 cites W1985141838 @default.
• W2954205159 cites W1985307512 @default.
• W2954205159 cites W1985757967 @default.
• W2954205159 cites W1987827916 @default.
• W2954205159 cites W1990952007 @default.
• W2954205159 cites W1993289579 @default.
• W2954205159 cites W1999145399 @default.
• W2954205159 cites W1999425425 @default.
• W2954205159 cites W2001367511 @default.
• W2954205159 cites W2001835897 @default.
• W2954205159 cites W2003047888 @default.
• W2954205159 cites W2007951685 @default.
• W2954205159 cites W2009235563 @default.
• W2954205159 cites W2010743737 @default.
• W2954205159 cites W2015497140 @default.
• W2954205159 cites W2016749879 @default.
• W2954205159 cites W2019020433 @default.
• W2954205159 cites W2020837851 @default.
• W2954205159 cites W2021453893 @default.
• W2954205159 cites W2021709130 @default.
• W2954205159 cites W2021739252 @default.
• W2954205159 cites W2023476322 @default.
• W2954205159 cites W2024518923 @default.
• W2954205159 cites W2031159533 @default.
• W2954205159 cites W2032110253 @default.
• W2954205159 cites W2036043627 @default.
• W2954205159 cites W2037790468 @default.
• W2954205159 cites W2038266542 @default.
• W2954205159 cites W2040671157 @default.
• W2954205159 cites W2040925848 @default.
• W2954205159 cites W2041992162 @default.
• W2954205159 cites W2042221545 @default.
• W2954205159 cites W2049363817 @default.
• W2954205159 cites W2049517086 @default.
• W2954205159 cites W2052724934 @default.
• W2954205159 cites W2052968067 @default.
• W2954205159 cites W2054472012 @default.
• W2954205159 cites W2055814634 @default.
• W2954205159 cites W2058838648 @default.
• W2954205159 cites W2059001288 @default.
• W2954205159 cites W2060034277 @default.
• W2954205159 cites W2061320385 @default.
• W2954205159 cites W2067481123 @default.
• W2954205159 cites W2068367174 @default.
• W2954205159 cites W2073143479 @default.
• W2954205159 cites W2077436901 @default.
• W2954205159 cites W2080418085 @default.
• W2954205159 cites W2083620691 @default.
• W2954205159 cites W2087076671 @default.
• W2954205159 cites W2087842498 @default.
• W2954205159 cites W2088660937 @default.
• W2954205159 cites W2089717835 @default.
• W2954205159 cites W2090222281 @default.
• W2954205159 cites W2090608637 @default.
• W2954205159 cites W2092915897 @default.
• W2954205159 cites W2093249614 @default.
• W2954205159 cites W2096117281 @default.
• W2954205159 cites W2104209472 @default.
• W2954205159 cites W2105265963 @default.
• W2954205159 cites W2105438333 @default.
• W2954205159 cites W2107861279 @default.
• W2954205159 cites W2109299968 @default.
• W2954205159 cites W2109560663 @default.
• W2954205159 cites W2111017518 @default.
• W2954205159 cites W2111785233 @default.
• W2954205159 cites W2113829060 @default.
• W2954205159 cites W2116389513 @default.
• W2954205159 cites W2117451333 @default.
• W2954205159 cites W2119084971 @default.
• W2954205159 cites W2120763912 @default.
• W2954205159 cites W2123021239 @default.
• W2954205159 cites W2124317932 @default.
• W2954205159 cites W2125826979 @default.

• next