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• W2954221431 startingPage "1907" @default.
• W2954221431 abstract "Since successful cloning of thrombopoietin (TPO) in 1994, significant advances have been made in the development of recombinant TPO receptor agonists. The US Food and Drug Administration (FDA) has approved 2 agents for use in patients with immune thrombocytopenia (ITP): eltrombopag and romiplostim. Romiplostim is a once-weekly subcutaneous injection that has been shown to increase the platelet count, lessen bleeding, and reduce concurrent medication use in adults with ITP. In December 2018, the US FDA approved romiplostim for use in pediatric patients ≥1 year of age with ITP of >6 months’ duration and insufficient response to corticosteroids, immunoglobulins, or splenectomy, based on similarly favorable clinical trial data. In addition, romiplostim is well tolerated, making it an attractive option for the treatment of children. Expansion of off-label romiplostim use is being reported in children for ITP <6 months, neonatal thrombocytopenia, hereditary thrombocytopenias, and chemotherapy- and bone marrow transplant–associated thrombocytopenia. We review here the development of romiplostim with a focus on pediatric use. Subjects: Clinical Trials and Observations, Drug Advances, Platelets and Thrombopoiesis Topics: pediatrics, romiplostim, thrombocytopenia due to immune destruction, platelet count measurement, thrombocytopenia, eltrombopag, purpura, thrombocytopenic, idiopathic, child, hemorrhage" @default.
• W2954221431 created "2019-07-12" @default.
• W2954221431 creator A5014340929 @default.
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• W2954221431 date "2019-06-25" @default.
• W2954221431 modified "2023-10-03" @default.
• W2954221431 title "Romiplostim for the management of pediatric immune thrombocytopenia: drug development and current practice" @default.
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• W2954221431 doi "https://doi.org/10.1182/bloodadvances.2019000279" @default.
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