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- W2954236468 endingPage "881" @default.
- W2954236468 startingPage "867" @default.
- W2954236468 abstract "The observation that cysteine is the top gainer amino acid during evolution attracted the attention of scientists dealing with protein chemistry. The thiol group of cysteine, indeed, is a potential site for several types of reactions with variable specificity and strength. This feature proved to be promising also in the field of membrane transporters that represent boundary proteins fundamental for cell homeostasis. These proteins are classified, according to the driving force for transport, in primary or secondary active transporters. Another frequently used classification is nowadays based on phylogenesis. Two major groups are identified that take into account both criteria: the ABC and the SLC transporters, the second being much more numerous. The cellular localization of the transporters makes them very attractive for drug design. Moreover, the presence of at least one cysteine residue in all the annotated SLC transporters, so far, highlights the possibility of using the thiol (SH) residue for covalent drug targeting. Even if a delay exists in this research field due to the scarce knowledge of structure/function relationships, the setup of novel experimental tools for studying SLC proteins of plasma and organelle membranes opens an important perspective in pharmacology." @default.
- W2954236468 created "2019-07-12" @default.
- W2954236468 creator A5002150589 @default.
- W2954236468 creator A5023202830 @default.
- W2954236468 creator A5023301307 @default.
- W2954236468 creator A5029021626 @default.
- W2954236468 creator A5044257332 @default.
- W2954236468 creator A5050482110 @default.
- W2954236468 creator A5073327143 @default.
- W2954236468 date "2019-10-01" @default.
- W2954236468 modified "2023-10-11" @default.
- W2954236468 title "Exploiting Cysteine Residues of SLC Membrane Transporters as Targets for Drugs" @default.
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