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• W2954293812 abstract "Aneuploidy (changes in chromosome number) and loss of heterozygosity (LOH) occur frequently in the human-pathogenic yeast Candida albicans and are associated with adaptation to stress and to antifungal drugs. Aneuploidy and LOH can also be induced during laboratory manipulations, such as during genetic transformation. We find that C. albicans strain SN152, commonly used to generate gene deletions, has undergone a major LOH event on chromosome 2. One deletion strain generated in this background has acquired extra copies of chromosomes 5 and 7. We find that trisomy (three copies) of chromosome 7 is associated with sensitivity to fatty acids." @default.
• W2954293812 created "2019-07-12" @default.
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• W2954293812 date "2019-06-26" @default.
• W2954293812 modified "2023-09-27" @default.
• W2954293812 title "Susceptibility to Medium-Chain Fatty Acids Is Associated with Trisomy of Chromosome 7 in <i>Candida albicans</i>" @default.
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• W2954293812 doi "https://doi.org/10.1128/msphere.00402-19" @default.
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