Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954298794> ?p ?o ?g. }
- W2954298794 abstract "Abstract Tendon disorders frequently occur and recent evidence has clearly implicated the presence of immune cells and inflammatory events during early tendinopathy. However, the origin and properties of these cells remain poorly defined. Therefore, the aim of this study was to determine the presence of myleoid cells in healthy rodent and human tendon tissue and to characterize them. Using various transgenic reporter mouse models, we demonstrate the presence of tendon cells in the dense matrix of the tendon core expressing the fractalkine (Fkn) receptor CX3CR1 and its cognate ligand CX3CL1/Fkn. Pro-inflammatory stimulation of 3D tendon-like constructs in vitro resulted in a significant increase in the expression of IL-1β, IL-6, Mmp3, Mmp9, Cx3cl1, and epiregulin which has been reported to contribute to inflammation, wound healing, and tissue repair. Furthermore, we demonstrate that inhibition of the fractalkine receptor blocked tendon cell migration in vitro and show the presence of CX3CR1/CX3CL1/EREG expressing cells in healthy human tendons. Taken together, we demonstrate the presence of CX3CL1+/CX3CR1+ “tenophages” within the healthy tendon proper potentially fulfilling surveillance functions in tendons. Summary Statement Here, we demonstrate the presence of a macrophage-like, CX3CL1/CX3CR1-expressing cell population within the healthy tendon proper potentially fulfilling a surveillance function." @default.
- W2954298794 created "2019-07-12" @default.
- W2954298794 creator A5000692676 @default.
- W2954298794 creator A5024161366 @default.
- W2954298794 creator A5027901669 @default.
- W2954298794 creator A5034230405 @default.
- W2954298794 creator A5035986184 @default.
- W2954298794 creator A5040101603 @default.
- W2954298794 creator A5054394977 @default.
- W2954298794 creator A5057164907 @default.
- W2954298794 creator A5075691726 @default.
- W2954298794 creator A5080158579 @default.
- W2954298794 date "2019-07-04" @default.
- W2954298794 modified "2023-09-29" @default.
- W2954298794 title "CX3CL1 and CX3CR1 Expressing Tendon Cells – A novel Immune Cell Population in the Tendon Core" @default.
- W2954298794 cites W1496307550 @default.
- W2954298794 cites W1535567348 @default.
- W2954298794 cites W1577577364 @default.
- W2954298794 cites W193983472 @default.
- W2954298794 cites W1977245294 @default.
- W2954298794 cites W1980955814 @default.
- W2954298794 cites W1982931411 @default.
- W2954298794 cites W1984115097 @default.
- W2954298794 cites W1985502949 @default.
- W2954298794 cites W1987670613 @default.
- W2954298794 cites W2008669330 @default.
- W2954298794 cites W2009302738 @default.
- W2954298794 cites W2026239870 @default.
- W2954298794 cites W2026578487 @default.
- W2954298794 cites W2043939614 @default.
- W2954298794 cites W2055221807 @default.
- W2954298794 cites W2056955500 @default.
- W2954298794 cites W2059858274 @default.
- W2954298794 cites W2063215851 @default.
- W2954298794 cites W2064063596 @default.
- W2954298794 cites W2080066374 @default.
- W2954298794 cites W2080844075 @default.
- W2954298794 cites W2085600478 @default.
- W2954298794 cites W2088098711 @default.
- W2954298794 cites W2089836937 @default.
- W2954298794 cites W2111827378 @default.
- W2954298794 cites W2118037848 @default.
- W2954298794 cites W2124392720 @default.
- W2954298794 cites W2127514713 @default.
- W2954298794 cites W2128174415 @default.
- W2954298794 cites W2128514908 @default.
- W2954298794 cites W2130755020 @default.
- W2954298794 cites W2130812933 @default.
- W2954298794 cites W2138882004 @default.
- W2954298794 cites W2148163330 @default.
- W2954298794 cites W2157068274 @default.
- W2954298794 cites W2161057248 @default.
- W2954298794 cites W2263276375 @default.
- W2954298794 cites W2297608814 @default.
- W2954298794 cites W2465161746 @default.
- W2954298794 cites W2506892818 @default.
- W2954298794 cites W2626556529 @default.
- W2954298794 cites W2742580821 @default.
- W2954298794 cites W2765651830 @default.
- W2954298794 cites W2778461527 @default.
- W2954298794 cites W2785747601 @default.
- W2954298794 cites W2789956380 @default.
- W2954298794 cites W2915828703 @default.
- W2954298794 cites W4233297768 @default.
- W2954298794 cites W938579619 @default.
- W2954298794 cites W2912796589 @default.
- W2954298794 doi "https://doi.org/10.1101/693317" @default.
- W2954298794 hasPublicationYear "2019" @default.
- W2954298794 type Work @default.
- W2954298794 sameAs 2954298794 @default.
- W2954298794 citedByCount "0" @default.
- W2954298794 crossrefType "posted-content" @default.
- W2954298794 hasAuthorship W2954298794A5000692676 @default.
- W2954298794 hasAuthorship W2954298794A5024161366 @default.
- W2954298794 hasAuthorship W2954298794A5027901669 @default.
- W2954298794 hasAuthorship W2954298794A5034230405 @default.
- W2954298794 hasAuthorship W2954298794A5035986184 @default.
- W2954298794 hasAuthorship W2954298794A5040101603 @default.
- W2954298794 hasAuthorship W2954298794A5054394977 @default.
- W2954298794 hasAuthorship W2954298794A5057164907 @default.
- W2954298794 hasAuthorship W2954298794A5075691726 @default.
- W2954298794 hasAuthorship W2954298794A5080158579 @default.
- W2954298794 hasBestOaLocation W29542987941 @default.
- W2954298794 hasConcept C12823836 @default.
- W2954298794 hasConcept C13373296 @default.
- W2954298794 hasConcept C137738243 @default.
- W2954298794 hasConcept C142724271 @default.
- W2954298794 hasConcept C1491633281 @default.
- W2954298794 hasConcept C203014093 @default.
- W2954298794 hasConcept C2776914184 @default.
- W2954298794 hasConcept C2778911562 @default.
- W2954298794 hasConcept C2780105995 @default.
- W2954298794 hasConcept C2908647359 @default.
- W2954298794 hasConcept C31179232 @default.
- W2954298794 hasConcept C54355233 @default.
- W2954298794 hasConcept C71924100 @default.
- W2954298794 hasConcept C82321936 @default.
- W2954298794 hasConcept C86803240 @default.
- W2954298794 hasConcept C95444343 @default.
- W2954298794 hasConcept C99454951 @default.