FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954326918> ?p ?o ?g. }

• W2954326918 endingPage "118472" @default.
• W2954326918 startingPage "118472" @default.
• W2954326918 abstract "Candida albicans, as the main causative fungus of vaginal candidiasis, is currently a global issue of concern due to its high prevalence, biofilm formation and emergence of resistance. Ketoconazole (KTZ), an antifungal drug, which has poor water-solubility and penetration capacity, is ineffective against deep-seated Candida infection. Considering these issues, this work aimed to develop a novel multifunctional carrier for KTZ via encapsulation of KTZ/β-cyclodextrin (β-CD) co-ground mixture into chitosan/gellan gum gel-flakes (threadlike and polygonal structures). Analytical studies revealed existence of electrostatic-derived complexes between negatively charged gellan gum and positively charged chitosan. Gel-flakes were then loaded in in situ gel of pluronic F-127 (PF-127). Based on gelation temperature (Tgel), viscosity and release studies; selected formulation was further evaluated, showing significant in vitro anti-candida activity. Despite reduced dosage regimen (50 mg/daily/three days), KTZ flakes in situ gel was as effective as Gynoconazol vaginal cream® (80 mg terconazole/daily/three days) in improving patient complaints and Candida eradication. Multifunctionality of KTZ carrier was based on efficient spreading and coating of the vagina due to free-flowing properties during application, flakes entanglement within folded vaginal epithelia, sustained release and increased penetration capacity of KTZ to reach deep-seated infections. In conclusion, flakes in situ gel could be considered as a highly promising KTZ delivery option for treatment of vaginal candidiasis." @default.
• W2954326918 created "2019-07-12" @default.
• W2954326918 creator A5004197854 @default.
• W2954326918 creator A5005646734 @default.
• W2954326918 creator A5014605545 @default.
• W2954326918 creator A5044113842 @default.
• W2954326918 creator A5054000263 @default.
• W2954326918 creator A5066619473 @default.
• W2954326918 date "2019-08-01" @default.
• W2954326918 modified "2023-09-23" @default.
• W2954326918 title "Efficacy of ketoconazole gel-flakes in treatment of vaginal candidiasis: Formulation, in vitro and clinical evaluation" @default.
• W2954326918 cites W1983269317 @default.
• W2954326918 cites W1986888271 @default.
• W2954326918 cites W1987065337 @default.
• W2954326918 cites W1988088986 @default.
• W2954326918 cites W1991173262 @default.
• W2954326918 cites W2000109642 @default.
• W2954326918 cites W2001570423 @default.
• W2954326918 cites W2005117134 @default.
• W2954326918 cites W2008995016 @default.
• W2954326918 cites W2021982767 @default.
• W2954326918 cites W2036156670 @default.
• W2954326918 cites W2037267605 @default.
• W2954326918 cites W2040284399 @default.
• W2954326918 cites W2040810538 @default.
• W2954326918 cites W2052634646 @default.
• W2954326918 cites W2053080702 @default.
• W2954326918 cites W2056255938 @default.
• W2954326918 cites W2058509094 @default.
• W2954326918 cites W2061408471 @default.
• W2954326918 cites W2063801124 @default.
• W2954326918 cites W2064135629 @default.
• W2954326918 cites W2071713533 @default.
• W2954326918 cites W2075432922 @default.
• W2954326918 cites W2081405820 @default.
• W2954326918 cites W2082276469 @default.
• W2954326918 cites W2082593275 @default.
• W2954326918 cites W2090766334 @default.
• W2954326918 cites W2091742793 @default.
• W2954326918 cites W2095934059 @default.
• W2954326918 cites W2117973832 @default.
• W2954326918 cites W2138170968 @default.
• W2954326918 cites W2140911881 @default.
• W2954326918 cites W2147286931 @default.
• W2954326918 cites W2156192330 @default.
• W2954326918 cites W2273594182 @default.
• W2954326918 cites W2333477160 @default.
• W2954326918 cites W2546530683 @default.
• W2954326918 cites W2792493819 @default.
• W2954326918 cites W2807934072 @default.
• W2954326918 cites W2953133226 @default.
• W2954326918 cites W86240330 @default.
• W2954326918 doi "https://doi.org/10.1016/j.ijpharm.2019.118472" @default.
• W2954326918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31252146" @default.
• W2954326918 hasPublicationYear "2019" @default.
• W2954326918 type Work @default.
• W2954326918 sameAs 2954326918 @default.
• W2954326918 citedByCount "29" @default.
• W2954326918 countsByYear W29543269182020 @default.
• W2954326918 countsByYear W29543269182021 @default.
• W2954326918 countsByYear W29543269182022 @default.
• W2954326918 countsByYear W29543269182023 @default.
• W2954326918 crossrefType "journal-article" @default.
• W2954326918 hasAuthorship W2954326918A5004197854 @default.
• W2954326918 hasAuthorship W2954326918A5005646734 @default.
• W2954326918 hasAuthorship W2954326918A5014605545 @default.
• W2954326918 hasAuthorship W2954326918A5044113842 @default.
• W2954326918 hasAuthorship W2954326918A5054000263 @default.
• W2954326918 hasAuthorship W2954326918A5066619473 @default.
• W2954326918 hasConcept C101335993 @default.
• W2954326918 hasConcept C127413603 @default.
• W2954326918 hasConcept C15920480 @default.
• W2954326918 hasConcept C178790620 @default.
• W2954326918 hasConcept C185592680 @default.
• W2954326918 hasConcept C192562407 @default.
• W2954326918 hasConcept C197746943 @default.
• W2954326918 hasConcept C203014093 @default.
• W2954326918 hasConcept C2779548794 @default.
• W2954326918 hasConcept C2780917455 @default.
• W2954326918 hasConcept C2781064554 @default.
• W2954326918 hasConcept C2781220964 @default.
• W2954326918 hasConcept C3013748606 @default.
• W2954326918 hasConcept C31903555 @default.
• W2954326918 hasConcept C42475967 @default.
• W2954326918 hasConcept C43617362 @default.
• W2954326918 hasConcept C521977710 @default.
• W2954326918 hasConcept C71924100 @default.
• W2954326918 hasConcept C77281830 @default.
• W2954326918 hasConcept C80107235 @default.
• W2954326918 hasConcept C86803240 @default.
• W2954326918 hasConcept C89423630 @default.
• W2954326918 hasConceptScore W2954326918C101335993 @default.
• W2954326918 hasConceptScore W2954326918C127413603 @default.
• W2954326918 hasConceptScore W2954326918C15920480 @default.
• W2954326918 hasConceptScore W2954326918C178790620 @default.
• W2954326918 hasConceptScore W2954326918C185592680 @default.
• W2954326918 hasConceptScore W2954326918C192562407 @default.
• W2954326918 hasConceptScore W2954326918C197746943 @default.

• next