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- W2954332222 abstract "The eastern Russell’s viper, Daboia siamensis, is one of the important venomous snakes causing serious public health problems in Southeast Asia. Its venom contains a variety of enzymes and peptides that cause hemotoxic effects. Since antivenin commonly used for treating snakebite patients may lead to lethal allergic reaction, medicinal herbs have become an important alternative remedy. To find effective herbs, appropriate screening assays specific to snake venom are needed. This study aims to develop appropriate in vitro assays for screening medicinal herbs that have anti-hemotoxic activity against D. siamensis venom. Five assays corresponded to important biological activities of the venom were tested. Results revealed that 3 out of 5 assays were effective in showing markedly difference between positive and negative controls including 1) phospholipase A2 assay examining diameter of clear zone around the well in agar plate with yolk solution, 2) coagulation assay measuring increase in optical density of the plasma after venom addition, and 3) fibrinogenolytic assay examining cleavage of alpha-fibrinopeptide in the SDS-PAGE. No significant difference between positive and negative controls was found in proteolytic and hemagglutination assays. These selected essays can be further incorporated with in vivo assay(s) to screen for effective herbs against D. siamensis venom." @default.
- W2954332222 created "2019-07-12" @default.
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- W2954332222 date "2019-01-01" @default.
- W2954332222 modified "2023-10-14" @default.
- W2954332222 title "Development of in vitro assays for hematotoxic activity of the Russell’s viper Daboia siamensis venom" @default.
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- W2954332222 doi "https://doi.org/10.1063/1.5115729" @default.
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