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• W2954343358 startingPage "1" @default.
• W2954343358 abstract "Autism spectrum disorders (ASD) are neurodevelopmental disorders induced by genetic and environmental factors. In our recent studies, we showed that the GABA developmental shifts during delivery and the second postnatal week are abolished in two rodent models of ASD. Maternal treatment around birth with bumetanide restored the GABA developmental sequence and attenuated the autism pathogenesis in offspring. Clinical trials conducted in parallel confirmed the usefulness of bumetanide treatment to attenuate the symptoms in children with ASD. Collectively, these observations suggest that an alteration of the GABA developmental sequence is a hallmark of ASD. Here, we investigated whether similar alterations occur in the Shank3 mouse model of ASD. We report that in CA3 pyramidal neurons, the driving force and inhibitory action of GABA are not different in naïve and Shank3-mutant age-matched animals at birth and during the second postnatal week. In contrast, the frequency of spontaneous excitatory postsynaptic currents is already enhanced at birth and persists through postnatal day 15. Therefore, in CA3 pyramidal neurons of Shank3-mutant mice, glutamatergic but not GABAergic activity is affected at early developmental stages, hence reflecting the heterogeneity of mechanisms underlying the pathogenesis of ASD." @default.
• W2954343358 created "2019-07-12" @default.
• W2954343358 creator A5004012507 @default.
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• W2954343358 date "2019-07-03" @default.
• W2954343358 modified "2023-10-18" @default.
• W2954343358 title "Enhanced Glutamatergic Currents at Birth in Shank3 KO Mice" @default.
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• W2954343358 cites W1966097738 @default.
• W2954343358 cites W1966761076 @default.
• W2954343358 cites W1977415662 @default.
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• W2954343358 cites W1983769138 @default.
• W2954343358 cites W1983784678 @default.
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• W2954343358 cites W2035803576 @default.
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• W2954343358 cites W2117421244 @default.
• W2954343358 cites W2118607380 @default.
• W2954343358 cites W2119535735 @default.
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• W2954343358 cites W2129455633 @default.
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• W2954343358 cites W2375456630 @default.
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• W2954343358 cites W2402187732 @default.
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• W2954343358 doi "https://doi.org/10.1155/2019/2382639" @default.
• W2954343358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6636579" @default.
• W2954343358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31354805" @default.
• W2954343358 hasPublicationYear "2019" @default.
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