FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954356893> ?p ?o ?g. }

• W2954356893 endingPage "2132" @default.
• W2954356893 startingPage "2117" @default.
• W2954356893 abstract "ABSTRACT Osteoblast (OB) lineage cells are an important source of vascular endothelial growth factor (VEGF), which is critical for bone growth and repair. During bone development, pubertal differences in males and females exist, but little is known about whether VEGF signaling contributes to skeletal sexual dimorphism. We have found that in mice, conditional disruption of VEGF in osteocalcin‐expressing cells (OcnVEGFKO) exerts a divergent influence on morphological, cellular, and whole bone properties between sexes. Furthermore, we describe an underlying sexual divergence in VEGF signaling in OB cultures in vitro independent of circulating sex hormones. High‐resolution synchrotron computed tomography and backscattered scanning electron microscopy revealed, in males, extensive unmineralized osteoid encasing enlarged blood vessel canals and osteocyte lacunae in cortical bone after VEGF deletion, which contributed to increased porosity. VEGF was deleted in male and female long bone–derived OBs (OBVEGKO) in vitro and Raman spectroscopic analyses of mineral and matrix repertoires highlighted differences between male and female OBVEGFKO cells, with increased immature phosphate species prevalent in male OBVEGFKO cultures versus wild type (WT). Further sexual dimorphism was observed in bone marrow endothelial cell gene expression in vitro after VEGF deletion and in sclerostin protein expression, which was increased in male OcnVEGFKO bones versus WT. The impact of altered OB matrix composition after VEGF deletion on whole bone geometry was assessed between sexes, although significant differences between OcnVEGFKO and WT were identified only in females. Our results suggest that bone‐derived VEGF regulates matrix mineralization and vascularization distinctly in males and females, which results in divergent physical bone traits." @default.
• W2954356893 created "2019-07-12" @default.
• W2954356893 creator A5005830135 @default.
• W2954356893 creator A5013237227 @default.
• W2954356893 creator A5018577391 @default.
• W2954356893 creator A5020057358 @default.
• W2954356893 creator A5023907372 @default.
• W2954356893 creator A5030305021 @default.
• W2954356893 creator A5032320960 @default.
• W2954356893 creator A5038260702 @default.
• W2954356893 creator A5050887535 @default.
• W2954356893 creator A5052538302 @default.
• W2954356893 creator A5058605768 @default.
• W2954356893 creator A5063337734 @default.
• W2954356893 creator A5091749009 @default.
• W2954356893 date "2019-10-09" @default.
• W2954356893 modified "2023-10-17" @default.
• W2954356893 title "Regulation of the Bone Vascular Network is Sexually Dimorphic" @default.
• W2954356893 cites W1828557782 @default.
• W2954356893 cites W1829391012 @default.
• W2954356893 cites W1917177567 @default.
• W2954356893 cites W1938507131 @default.
• W2954356893 cites W1963556609 @default.
• W2954356893 cites W1967212422 @default.
• W2954356893 cites W1975791510 @default.
• W2954356893 cites W1980435596 @default.
• W2954356893 cites W1985547648 @default.
• W2954356893 cites W1992150054 @default.
• W2954356893 cites W2000202544 @default.
• W2954356893 cites W2000292756 @default.
• W2954356893 cites W2019113771 @default.
• W2954356893 cites W2019214663 @default.
• W2954356893 cites W2020730431 @default.
• W2954356893 cites W2028062768 @default.
• W2954356893 cites W2052854307 @default.
• W2954356893 cites W2053648508 @default.
• W2954356893 cites W2056810908 @default.
• W2954356893 cites W2061450074 @default.
• W2954356893 cites W2066749771 @default.
• W2954356893 cites W2076436405 @default.
• W2954356893 cites W2077348706 @default.
• W2954356893 cites W2081495924 @default.
• W2954356893 cites W2084874657 @default.
• W2954356893 cites W2087286553 @default.
• W2954356893 cites W2088798468 @default.
• W2954356893 cites W2089254126 @default.
• W2954356893 cites W2101682146 @default.
• W2954356893 cites W2130607897 @default.
• W2954356893 cites W2135186545 @default.
• W2954356893 cites W2137339494 @default.
• W2954356893 cites W2137830201 @default.
• W2954356893 cites W2144004177 @default.
• W2954356893 cites W2155907836 @default.
• W2954356893 cites W2158135268 @default.
• W2954356893 cites W2172197499 @default.
• W2954356893 cites W2225056950 @default.
• W2954356893 cites W2466006418 @default.
• W2954356893 cites W2611033851 @default.
• W2954356893 cites W2756101256 @default.
• W2954356893 cites W2761459153 @default.
• W2954356893 cites W2791185454 @default.
• W2954356893 cites W280215210 @default.
• W2954356893 cites W2804277886 @default.
• W2954356893 doi "https://doi.org/10.1002/jbmr.3825" @default.
• W2954356893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6899569" @default.
• W2954356893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31269275" @default.
• W2954356893 hasPublicationYear "2019" @default.
• W2954356893 type Work @default.
• W2954356893 sameAs 2954356893 @default.
• W2954356893 citedByCount "17" @default.
• W2954356893 countsByYear W29543568932021 @default.
• W2954356893 countsByYear W29543568932022 @default.
• W2954356893 countsByYear W29543568932023 @default.
• W2954356893 crossrefType "journal-article" @default.
• W2954356893 hasAuthorship W2954356893A5005830135 @default.
• W2954356893 hasAuthorship W2954356893A5013237227 @default.
• W2954356893 hasAuthorship W2954356893A5018577391 @default.
• W2954356893 hasAuthorship W2954356893A5020057358 @default.
• W2954356893 hasAuthorship W2954356893A5023907372 @default.
• W2954356893 hasAuthorship W2954356893A5030305021 @default.
• W2954356893 hasAuthorship W2954356893A5032320960 @default.
• W2954356893 hasAuthorship W2954356893A5038260702 @default.
• W2954356893 hasAuthorship W2954356893A5050887535 @default.
• W2954356893 hasAuthorship W2954356893A5052538302 @default.
• W2954356893 hasAuthorship W2954356893A5058605768 @default.
• W2954356893 hasAuthorship W2954356893A5063337734 @default.
• W2954356893 hasAuthorship W2954356893A5091749009 @default.
• W2954356893 hasBestOaLocation W29543568931 @default.
• W2954356893 hasConcept C105083479 @default.
• W2954356893 hasConcept C105702510 @default.
• W2954356893 hasConcept C126322002 @default.
• W2954356893 hasConcept C131075544 @default.
• W2954356893 hasConcept C133605539 @default.
• W2954356893 hasConcept C134018914 @default.
• W2954356893 hasConcept C160160445 @default.
• W2954356893 hasConcept C167734588 @default.
• W2954356893 hasConcept C181199279 @default.
• W2954356893 hasConcept C202751555 @default.

• next