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• W2954392783 startingPage "1827" @default.
• W2954392783 abstract "Aim: We aim to use peptide nucleic acid (PNA) for antisense therapy against bovine viral diarrhea virus (BVDV), a surrogate model of human hepatitis C virus, and introduce an optimal approach for delivering PNA into the cell. Materials & methods: PNA was designed for hybridization to the 5′-untranslated region of BVDV RNA in order to form a heteroduplex structure and inhibit the translation and replication of virus. Gold nanoparticles (AuNPs) were used as a delivery system for PNA. Results: The cellular uptake of PNA-AuNPs and inhibition of BVDV infection in the middle stage of viral replication were found. Conclusion: Further research is warranted to develop AuNPs as a potential vehicle for delivering PNA in order to remove viruses from the infected cells." @default.
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• W2954392783 date "2019-07-01" @default.
• W2954392783 modified "2023-10-02" @default.
• W2954392783 title "Delivery of antisense peptide nucleic acid by gold nanoparticles for the inhibition of virus replication" @default.
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• W2954392783 doi "https://doi.org/10.2217/nnm-2018-0520" @default.
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