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- W2954416652 abstract "Strategies to control neovascularization in damaged tissues remain a key issue in regenerative medicine. Unlike most reported desferrioxamine (DFO)-loaded systems where DFO demonstrates a burst release, here we attain zero-order release behavior above 40 days. This outcome was achieved by blending DFO with silk nanofibers with special hydrophilic-hydrophobic properties. The special silk nanofibers showed strong physical binding capacity with DFO, avoiding chemical cross-linking. Using these new biomaterials in vivo in a rat wound model suggested that the DFO-loaded silk nanofiber hydrogel systems stimulated angiogenesis by the sustained release of DFO, but also facilitated cell migration and tissue ingrowth. These features resulted in faster formation of a blood vessel network in the wounds, as well improved healing when compared to the free DFO system. The DFO-loaded systems are also suitable for the regeneration of other tissues, such as nerve and bone, suggesting universality in the biomedical field." @default.
- W2954416652 created "2019-07-12" @default.
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- W2954416652 date "2019-06-28" @default.
- W2954416652 modified "2023-10-11" @default.
- W2954416652 title "Injectable Silk Nanofiber Hydrogels for Sustained Release of Small-Molecule Drugs and Vascularization" @default.
- W2954416652 cites W1965275473 @default.
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- W2954416652 cites W2006016787 @default.
- W2954416652 cites W2011107799 @default.
- W2954416652 cites W2019711191 @default.
- W2954416652 cites W2032306927 @default.
- W2954416652 cites W2052344865 @default.
- W2954416652 cites W2063596198 @default.
- W2954416652 cites W2065181822 @default.
- W2954416652 cites W2085195226 @default.
- W2954416652 cites W2085293124 @default.
- W2954416652 cites W2091324157 @default.
- W2954416652 cites W2091474534 @default.
- W2954416652 cites W2095298989 @default.
- W2954416652 cites W2095312143 @default.
- W2954416652 cites W2101588259 @default.
- W2954416652 cites W2106146695 @default.
- W2954416652 cites W2118294833 @default.
- W2954416652 cites W2139237341 @default.
- W2954416652 cites W2141312569 @default.
- W2954416652 cites W2181001225 @default.
- W2954416652 cites W2192188808 @default.
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- W2954416652 cites W2412816609 @default.
- W2954416652 cites W2415972197 @default.
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- W2954416652 cites W2465221033 @default.
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- W2954416652 cites W2479543668 @default.
- W2954416652 cites W2508171826 @default.
- W2954416652 cites W2520583051 @default.
- W2954416652 cites W2526165290 @default.
- W2954416652 cites W2528982998 @default.
- W2954416652 cites W2529655644 @default.
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- W2954416652 cites W2568379729 @default.
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- W2954416652 cites W2617618512 @default.
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- W2954416652 doi "https://doi.org/10.1021/acsbiomaterials.9b00621" @default.
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- W2954416652 hasPublicationYear "2019" @default.
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