FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954446054> ?p ?o ?g. }

• W2954446054 abstract "(E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-(3-(2-[18F]-fluoroethoxy)propyl) oxime ([18F]-PSS232) is a new PET tracer for imaging of metabotropic glutamate receptor subtype 5 (mGlu5), and has shown promising results in rodents and humans. The aim of this study was to estimate the radiation dosimetry and biodistribution in humans, to assess dose-limiting organs, and to demonstrate safety and tolerability of [18F]-PSS232 in healthy volunteers. PET/CT scans of six healthy male volunteers (mean age 23.5 ± 1.7; 21–26 years) were obtained after intravenous administration of 243 ± 3 MBq of [18F]-PSS232. Serial whole-body (vertex to mid-thigh) PET scans were assessed at ten time points, up to 90 min after tracer injection. Calculation of tracer kinetics and cumulated organ activities were performed using PMOD 3.7 software. Dosimetry estimates were calculated using the OLINDA/EXM software. Injection of [18F]-PSS232 was safe and well tolerated. Organs with highest absorbed doses were the gallbladder wall (0.2295 mGy/MBq), liver (0.0547 mGy/MBq), and the small intestine (0.0643 mGy/MBq). Mean effective dose was 3.72 ± 0.12 mSv/volunteer (range 3.61–3.96 mSv; 0.0153 mSv/MBq). [18F]-PSS232, a novel [18F]-labeled mGlu5 tracer, showed favorable dosimetry values. Additionally, the tracer was safe and well tolerated." @default.
• W2954446054 created "2019-07-12" @default.
• W2954446054 creator A5007536863 @default.
• W2954446054 creator A5014971081 @default.
• W2954446054 creator A5030877319 @default.
• W2954446054 creator A5035048827 @default.
• W2954446054 creator A5036774533 @default.
• W2954446054 creator A5041743198 @default.
• W2954446054 creator A5047331691 @default.
• W2954446054 creator A5080852796 @default.
• W2954446054 creator A5087643852 @default.
• W2954446054 creator A5088142967 @default.
• W2954446054 date "2019-06-25" @default.
• W2954446054 modified "2023-10-16" @default.
• W2954446054 title "Radiation dosimetry of [18F]-PSS232—a PET radioligand for imaging mGlu5 receptors in humans" @default.
• W2954446054 cites W1538617620 @default.
• W2954446054 cites W1929385113 @default.
• W2954446054 cites W2001131996 @default.
• W2954446054 cites W2045511585 @default.
• W2954446054 cites W2045511725 @default.
• W2954446054 cites W2059087548 @default.
• W2954446054 cites W2070149789 @default.
• W2954446054 cites W2079462982 @default.
• W2954446054 cites W2083033661 @default.
• W2954446054 cites W2088030336 @default.
• W2954446054 cites W2090813581 @default.
• W2954446054 cites W2105736320 @default.
• W2954446054 cites W2123557408 @default.
• W2954446054 cites W2149199906 @default.
• W2954446054 cites W2149984162 @default.
• W2954446054 cites W2155450622 @default.
• W2954446054 cites W2157609336 @default.
• W2954446054 cites W2160278266 @default.
• W2954446054 cites W2421284360 @default.
• W2954446054 cites W58578266 @default.
• W2954446054 cites W1984616393 @default.
• W2954446054 doi "https://doi.org/10.1186/s13550-019-0522-9" @default.
• W2954446054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6593000" @default.
• W2954446054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31240594" @default.
• W2954446054 hasPublicationYear "2019" @default.
• W2954446054 type Work @default.
• W2954446054 sameAs 2954446054 @default.
• W2954446054 citedByCount "3" @default.
• W2954446054 countsByYear W29544460542022 @default.
• W2954446054 countsByYear W29544460542023 @default.
• W2954446054 crossrefType "journal-article" @default.
• W2954446054 hasAuthorship W2954446054A5007536863 @default.
• W2954446054 hasAuthorship W2954446054A5014971081 @default.
• W2954446054 hasAuthorship W2954446054A5030877319 @default.
• W2954446054 hasAuthorship W2954446054A5035048827 @default.
• W2954446054 hasAuthorship W2954446054A5036774533 @default.
• W2954446054 hasAuthorship W2954446054A5041743198 @default.
• W2954446054 hasAuthorship W2954446054A5047331691 @default.
• W2954446054 hasAuthorship W2954446054A5080852796 @default.
• W2954446054 hasAuthorship W2954446054A5087643852 @default.
• W2954446054 hasAuthorship W2954446054A5088142967 @default.
• W2954446054 hasBestOaLocation W29544460541 @default.
• W2954446054 hasConcept C126322002 @default.
• W2954446054 hasConcept C149857219 @default.
• W2954446054 hasConcept C150903083 @default.
• W2954446054 hasConcept C170493617 @default.
• W2954446054 hasConcept C207001950 @default.
• W2954446054 hasConcept C2777807558 @default.
• W2954446054 hasConcept C2989005 @default.
• W2954446054 hasConcept C67847695 @default.
• W2954446054 hasConcept C71924100 @default.
• W2954446054 hasConcept C75088862 @default.
• W2954446054 hasConcept C86803240 @default.
• W2954446054 hasConceptScore W2954446054C126322002 @default.
• W2954446054 hasConceptScore W2954446054C149857219 @default.
• W2954446054 hasConceptScore W2954446054C150903083 @default.
• W2954446054 hasConceptScore W2954446054C170493617 @default.
• W2954446054 hasConceptScore W2954446054C207001950 @default.
• W2954446054 hasConceptScore W2954446054C2777807558 @default.
• W2954446054 hasConceptScore W2954446054C2989005 @default.
• W2954446054 hasConceptScore W2954446054C67847695 @default.
• W2954446054 hasConceptScore W2954446054C71924100 @default.
• W2954446054 hasConceptScore W2954446054C75088862 @default.
• W2954446054 hasConceptScore W2954446054C86803240 @default.
• W2954446054 hasIssue "1" @default.
• W2954446054 hasLocation W29544460541 @default.
• W2954446054 hasLocation W29544460542 @default.
• W2954446054 hasLocation W29544460543 @default.
• W2954446054 hasLocation W29544460544 @default.
• W2954446054 hasLocation W29544460545 @default.
• W2954446054 hasLocation W29544460546 @default.
• W2954446054 hasLocation W29544460547 @default.
• W2954446054 hasOpenAccess W2954446054 @default.
• W2954446054 hasPrimaryLocation W29544460541 @default.
• W2954446054 hasRelatedWork W1979441788 @default.
• W2954446054 hasRelatedWork W1999605359 @default.
• W2954446054 hasRelatedWork W2043677014 @default.
• W2954446054 hasRelatedWork W2087130573 @default.
• W2954446054 hasRelatedWork W2151908951 @default.
• W2954446054 hasRelatedWork W2508336498 @default.
• W2954446054 hasRelatedWork W2749063204 @default.
• W2954446054 hasRelatedWork W2885376240 @default.
• W2954446054 hasRelatedWork W2954446054 @default.
• W2954446054 hasRelatedWork W2965802642 @default.
• W2954446054 hasVolume "9" @default.

• next