FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954462494> ?p ?o ?g. }

• W2954462494 abstract "Abstract Background This study aimed to explore the correlation of circulating microRNA (miRNA) expression profile with clinical response to tumor necrosis factor (TNF) inhibitor in treating rheumatoid arthritis (RA) patients. Methods Baseline PBMC samples from eight responders and eight non‐responders after 24‐week TNF inhibitor (etanercept) treatment were subjected to miRNA microarray. Then, top 10 dysregulated miRNAs were selected and further validated by quantitative polymerase chain reaction (qPCR) in baseline PBMC samples from 92 RA patients treated with 24‐week TNF inhibitor (etanercept). Responders and non‐responders were divided referring to the decline in disease activity score in 28 joints. Results In microarray assay, total 59 upregulated and 78 downregulated miRNAs were identified in responders compared to non‐responders, which were mainly enriched in regulating immune‐ and inflammation‐related biological processes and pathways. The top 10 dysregulated miRNAs were as follows: miR‐192‐5p, miR‐146a‐5p, miR‐19b‐3p, miR‐320c, miR‐335‐5p, miR‐149‐3p, miR‐766‐3p, let‐7a‐5p, miR‐24‐3p, and miR‐1226‐5p. In qPCR validation, miR‐146a‐5p was increased, while let‐7a‐5p was decreased in responders compared with non‐responders. Multivariate logistic analysis illuminated that miR‐146a‐5p and CRP independently correlated with higher clinical response, while let‐7a‐5p and biologics history independently associated with lower clinical response. Subsequently, receiver operating characteristic curve showed that combination of these four independent factors presented with a great predictive value for clinical response with area under curve: 0.863, 95% CI 0.781‐0.945. Conclusion miRNA expression profile is closely implicated in the treatment efficacy of TNF inhibitor, and combined measurement of miR‐146a‐5p, let‐7a‐5p, CRP, and biologics history disclosed a great predictive value for clinical response to TNF inhibitor in RA patients." @default.
• W2954462494 created "2019-07-12" @default.
• W2954462494 creator A5011564164 @default.
• W2954462494 creator A5015978145 @default.
• W2954462494 creator A5037829735 @default.
• W2954462494 creator A5082060843 @default.
• W2954462494 creator A5085268616 @default.
• W2954462494 creator A5089828986 @default.
• W2954462494 date "2019-06-27" @default.
• W2954462494 modified "2023-10-18" @default.
• W2954462494 title "Correlation of microRNA expression profile with clinical response to tumor necrosis factor inhibitor in treating rheumatoid arthritis patients: A prospective cohort study" @default.
• W2954462494 cites W1996639668 @default.
• W2954462494 cites W2000905503 @default.
• W2954462494 cites W2001476170 @default.
• W2954462494 cites W2005440577 @default.
• W2954462494 cites W2020599612 @default.
• W2954462494 cites W2023495875 @default.
• W2954462494 cites W2033459613 @default.
• W2954462494 cites W2090532253 @default.
• W2954462494 cites W2099802544 @default.
• W2954462494 cites W2102544382 @default.
• W2954462494 cites W2116763826 @default.
• W2954462494 cites W2121843920 @default.
• W2954462494 cites W2127669794 @default.
• W2954462494 cites W2170989872 @default.
• W2954462494 cites W2302089568 @default.
• W2954462494 cites W2343700030 @default.
• W2954462494 cites W2409364676 @default.
• W2954462494 cites W2412747983 @default.
• W2954462494 cites W2511801079 @default.
• W2954462494 cites W2566588825 @default.
• W2954462494 cites W2577604108 @default.
• W2954462494 cites W2610021903 @default.
• W2954462494 cites W2613653038 @default.
• W2954462494 cites W2614331206 @default.
• W2954462494 cites W2616569123 @default.
• W2954462494 cites W2620963691 @default.
• W2954462494 cites W2621337629 @default.
• W2954462494 cites W2622000437 @default.
• W2954462494 cites W2622265102 @default.
• W2954462494 cites W2623617647 @default.
• W2954462494 cites W2743911448 @default.
• W2954462494 cites W2757030084 @default.
• W2954462494 cites W2895590824 @default.
• W2954462494 cites W2917800966 @default.
• W2954462494 cites W4235240484 @default.
• W2954462494 cites W4253796858 @default.
• W2954462494 cites W750760073 @default.
• W2954462494 cites W911382732 @default.
• W2954462494 doi "https://doi.org/10.1002/jcla.22953" @default.
• W2954462494 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6757134" @default.
• W2954462494 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31245894" @default.
• W2954462494 hasPublicationYear "2019" @default.
• W2954462494 type Work @default.
• W2954462494 sameAs 2954462494 @default.
• W2954462494 citedByCount "25" @default.
• W2954462494 countsByYear W29544624942020 @default.
• W2954462494 countsByYear W29544624942021 @default.
• W2954462494 countsByYear W29544624942022 @default.
• W2954462494 countsByYear W29544624942023 @default.
• W2954462494 crossrefType "journal-article" @default.
• W2954462494 hasAuthorship W2954462494A5011564164 @default.
• W2954462494 hasAuthorship W2954462494A5015978145 @default.
• W2954462494 hasAuthorship W2954462494A5037829735 @default.
• W2954462494 hasAuthorship W2954462494A5082060843 @default.
• W2954462494 hasAuthorship W2954462494A5085268616 @default.
• W2954462494 hasAuthorship W2954462494A5089828986 @default.
• W2954462494 hasBestOaLocation W29544624941 @default.
• W2954462494 hasConcept C104317684 @default.
• W2954462494 hasConcept C126322002 @default.
• W2954462494 hasConcept C143998085 @default.
• W2954462494 hasConcept C145059251 @default.
• W2954462494 hasConcept C150194340 @default.
• W2954462494 hasConcept C151956035 @default.
• W2954462494 hasConcept C17991360 @default.
• W2954462494 hasConcept C186836561 @default.
• W2954462494 hasConcept C203014093 @default.
• W2954462494 hasConcept C2777077863 @default.
• W2954462494 hasConcept C2777226972 @default.
• W2954462494 hasConcept C2777575956 @default.
• W2954462494 hasConcept C2779722408 @default.
• W2954462494 hasConcept C2781197716 @default.
• W2954462494 hasConcept C48023723 @default.
• W2954462494 hasConcept C55493867 @default.
• W2954462494 hasConcept C58471807 @default.
• W2954462494 hasConcept C71924100 @default.
• W2954462494 hasConcept C76318530 @default.
• W2954462494 hasConcept C86803240 @default.
• W2954462494 hasConcept C90924648 @default.
• W2954462494 hasConceptScore W2954462494C104317684 @default.
• W2954462494 hasConceptScore W2954462494C126322002 @default.
• W2954462494 hasConceptScore W2954462494C143998085 @default.
• W2954462494 hasConceptScore W2954462494C145059251 @default.
• W2954462494 hasConceptScore W2954462494C150194340 @default.
• W2954462494 hasConceptScore W2954462494C151956035 @default.
• W2954462494 hasConceptScore W2954462494C17991360 @default.
• W2954462494 hasConceptScore W2954462494C186836561 @default.
• W2954462494 hasConceptScore W2954462494C203014093 @default.
• W2954462494 hasConceptScore W2954462494C2777077863 @default.
• W2954462494 hasConceptScore W2954462494C2777226972 @default.

• next