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• W2954463742 startingPage "1065" @default.
• W2954463742 abstract "Abstract Chronic high‐fat‐diet (HFD) consumption can lead to the development of brain insulin resistance, which then exerts deleterious effects on learning and memory. Activity‐regulated cytoskeleton‐associated protein (Arc) is a memory‐related protein, and its expression can be induced by insulin stimulation. In HFD‐fed animals, their basal Arc protein levels in cerebral cortex and hippocampus are reduced. However, the effects of HFD on novelty‐induced Arc protein expression that is important for cognitive function is still unknown. In the present study, after feeding HFD (60% kcal from fat) for 5 weeks, mice developed brain insulin resistance and had a significant reduction in the novelty‐induced but not the basal Arc protein levels in their hippocampi. Further experiments were performed in primary rat hippocampal neurons. The results show that, under the condition of neuronal insulin resistance, acute insulin stimulation induced less activation of the phosphatidylinositol 3‐kinase/protein kinase B/p70 ribosomal S6 kinase (PI3K/Akt/p70S6K) pathway, resulting in reduced induction of Arc protein expression. Accordingly, it is suggested that following HFD feeding, the reduction in novelty‐induced Arc protein expression in animal's hippocampus is probably related to a suppressed activation of the PI3K/Akt/p70S6K pathway due to the existence of brain insulin resistance." @default.
• W2954463742 created "2019-07-12" @default.
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• W2954463742 date "2019-07-01" @default.
• W2954463742 modified "2023-10-16" @default.
• W2954463742 title "High‐fat diet reduces novelty‐induced expression of activity‐regulated cytoskeleton‐associated protein" @default.
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• W2954463742 doi "https://doi.org/10.1002/jcp.29021" @default.
• W2954463742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31264208" @default.
• W2954463742 hasPublicationYear "2019" @default.
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