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- W2954465539 abstract "A cost effective, sensitive, simple, and rapid high-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of the prasugrel metabolite in human plasma. Following solid phase extraction, the analyte (prasugrel active metabolite; R-138727) and internal standard (emtricitabine) were separated using a mobile phase in an isocratic elution mode on a reverse phase C18 column and were analyzed by an LC–MS/MS in the multiple reaction monitoring mode using the respective [M+H]⁺ ions, m/z 498.3–206.0 for R-138727 and m/z 248.2–130.1 for the internal standard. The assay exhibited a linear dynamic range of 0.2–120ng/mL. The lower limit of quantification was 0.2ng/mL with a relative standard deviation of 5.0%. This LC–MS/MS method was validated with intra-batch and inter-batch precision and accuracy. Results for precision and accuracy are in range of 3.9–9.6% and 95.2–102.2% respectively. This validated method is simple and repeatable to use in bioequivalence/pharmacokinetic studies." @default.
- W2954465539 created "2019-07-12" @default.
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- W2954465539 date "2016-01-01" @default.
- W2954465539 modified "2023-09-24" @default.
- W2954465539 title "Analysis of prasugrel active metabolite R-138727 in human plasma: a sensitive, highly selective and fast LC–MS/MS method B Analytical technologies in the biomedical and life sciences" @default.
- W2954465539 hasPublicationYear "2016" @default.
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