FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954501229> ?p ?o ?g. }

• W2954501229 abstract "Abstract Background: Endometriosis is a chronic fibrotic disease characterized by agonizing pelvic pain and low fertility, mainly affecting middle-aged women. The aim of the present study is to assess the potential effects of erythropoietin-producing hepatocellular carcinoma A3 (EPHA3) on endometriosis, with emphasis on the autophagy and apoptosis of macrophages via inhibition of the mammalian target of rapamycin (mTOR) signaling pathway. Methods: The mouse models of endometriosis were established followed by culturing the macrophages and macrophage transfection via the EPHA3 vector, siRNA EPHA3, and RAPA (an inhibitor of the mTOR signaling pathway). The expression of EPHA3, related factors in the mTOR signaling pathway, macrophage autophagy (autophagy-related gene 3 (Atg3), light chain 3-I (LC3-I), light chain 3-II (LC3-II) and Beclin1) and apoptosis (B-cell lymphoma-2 (bcl-2), bax and fas) were all detected and documented, respectively. The changes of autophagic lysosomes and the apoptosis of macrophages in each group following transfection were also inspected and detected. Results: The results of the in silico analysis ascertained EPHA3 to be a candidate gene of endometriosis. After successful modeling, the uterine tissues of endometriosis mice presented with a low expression of EPHA3 and activated mTOR signaling pathway. Overexpression of EPHA3 inhibited the activation of the mTOR signaling pathway, down-regulated bcl-2 expression, up-regulated the expression of Atg3, LC3-II/LC3-I, Beclin1, bax and fas, and also promoted the autophagy and apoptosis of macrophages in endometriosis mice. Conclusion: Altogether, EPHA3 could potentially promote the autophagy and apoptosis of macrophages in endometriosis via inhibition of the mTOR signaling pathway, highlighting the potential of EPHA3 as the target to treat endometriosis." @default.
• W2954501229 created "2019-07-12" @default.
• W2954501229 creator A5015410302 @default.
• W2954501229 creator A5037349641 @default.
• W2954501229 creator A5055365275 @default.
• W2954501229 creator A5066253638 @default.
• W2954501229 creator A5068254469 @default.
• W2954501229 date "2019-07-01" @default.
• W2954501229 modified "2023-10-12" @default.
• W2954501229 title "EPHA3 enhances macrophage autophagy and apoptosis by disrupting the mTOR signaling pathway in mice with endometriosis" @default.
• W2954501229 cites W1523693806 @default.
• W2954501229 cites W1586151303 @default.
• W2954501229 cites W1927522118 @default.
• W2954501229 cites W1978194521 @default.
• W2954501229 cites W1992954695 @default.
• W2954501229 cites W2001083548 @default.
• W2954501229 cites W2001675597 @default.
• W2954501229 cites W2012650501 @default.
• W2954501229 cites W2014338423 @default.
• W2954501229 cites W2028744406 @default.
• W2954501229 cites W2031984119 @default.
• W2954501229 cites W2036406012 @default.
• W2954501229 cites W2036459481 @default.
• W2954501229 cites W2038385234 @default.
• W2954501229 cites W2048030072 @default.
• W2954501229 cites W2049615458 @default.
• W2954501229 cites W2085776608 @default.
• W2954501229 cites W2109034822 @default.
• W2954501229 cites W2120423827 @default.
• W2954501229 cites W2126904458 @default.
• W2954501229 cites W2134399937 @default.
• W2954501229 cites W2151735747 @default.
• W2954501229 cites W2152910765 @default.
• W2954501229 cites W2155295856 @default.
• W2954501229 cites W2165599785 @default.
• W2954501229 cites W2170916168 @default.
• W2954501229 cites W2326122459 @default.
• W2954501229 cites W2337998445 @default.
• W2954501229 cites W2345896299 @default.
• W2954501229 cites W2399977168 @default.
• W2954501229 cites W2477326720 @default.
• W2954501229 cites W2560536820 @default.
• W2954501229 cites W2581986521 @default.
• W2954501229 cites W2599335862 @default.
• W2954501229 cites W2608139107 @default.
• W2954501229 cites W2608827021 @default.
• W2954501229 cites W2790377547 @default.
• W2954501229 cites W2793391613 @default.
• W2954501229 cites W2824152503 @default.
• W2954501229 cites W346499765 @default.
• W2954501229 cites W2805693787 @default.
• W2954501229 doi "https://doi.org/10.1042/bsr20182274" @default.
• W2954501229 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6667729" @default.
• W2954501229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31262977" @default.
• W2954501229 hasPublicationYear "2019" @default.
• W2954501229 type Work @default.
• W2954501229 sameAs 2954501229 @default.
• W2954501229 citedByCount "8" @default.
• W2954501229 countsByYear W29545012292020 @default.
• W2954501229 countsByYear W29545012292021 @default.
• W2954501229 countsByYear W29545012292022 @default.
• W2954501229 countsByYear W29545012292023 @default.
• W2954501229 crossrefType "journal-article" @default.
• W2954501229 hasAuthorship W2954501229A5015410302 @default.
• W2954501229 hasAuthorship W2954501229A5037349641 @default.
• W2954501229 hasAuthorship W2954501229A5055365275 @default.
• W2954501229 hasAuthorship W2954501229A5066253638 @default.
• W2954501229 hasAuthorship W2954501229A5068254469 @default.
• W2954501229 hasBestOaLocation W29545012291 @default.
• W2954501229 hasConcept C126322002 @default.
• W2954501229 hasConcept C185592680 @default.
• W2954501229 hasConcept C190283241 @default.
• W2954501229 hasConcept C202751555 @default.
• W2954501229 hasConcept C203522944 @default.
• W2954501229 hasConcept C2779244956 @default.
• W2954501229 hasConcept C2779522080 @default.
• W2954501229 hasConcept C502942594 @default.
• W2954501229 hasConcept C54009773 @default.
• W2954501229 hasConcept C54355233 @default.
• W2954501229 hasConcept C55493867 @default.
• W2954501229 hasConcept C62478195 @default.
• W2954501229 hasConcept C71924100 @default.
• W2954501229 hasConcept C81885089 @default.
• W2954501229 hasConcept C86554907 @default.
• W2954501229 hasConcept C86803240 @default.
• W2954501229 hasConcept C95444343 @default.
• W2954501229 hasConceptScore W2954501229C126322002 @default.
• W2954501229 hasConceptScore W2954501229C185592680 @default.
• W2954501229 hasConceptScore W2954501229C190283241 @default.
• W2954501229 hasConceptScore W2954501229C202751555 @default.
• W2954501229 hasConceptScore W2954501229C203522944 @default.
• W2954501229 hasConceptScore W2954501229C2779244956 @default.
• W2954501229 hasConceptScore W2954501229C2779522080 @default.
• W2954501229 hasConceptScore W2954501229C502942594 @default.
• W2954501229 hasConceptScore W2954501229C54009773 @default.
• W2954501229 hasConceptScore W2954501229C54355233 @default.
• W2954501229 hasConceptScore W2954501229C55493867 @default.
• W2954501229 hasConceptScore W2954501229C62478195 @default.
• W2954501229 hasConceptScore W2954501229C71924100 @default.
• W2954501229 hasConceptScore W2954501229C81885089 @default.

• next