FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954515247> ?p ?o ?g. }

• W2954515247 abstract "Neoantigens that arise as a consequence of tumor-specific mutations can be recognized by T lymphocytes leading to effective immune surveillance. In colorectal cancer (CRC) and other tumor types, a high number of neoantigens is associated with patient response to immune therapies. The molecular processes governing the generation of neoantigens and their turnover in cancer cells are poorly understood. We exploited CRC as a model system to understand how alterations in DNA repair pathways modulate neoantigen profiles over time. We performed whole exome sequencing (WES) and RNA sequencing (RNAseq) in CRC cell lines, in vitro and in vivo, and in CRC patient-derived xenografts (PDXs) to track longitudinally genomic profiles, clonal evolution, mutational signatures, and predicted neoantigens. The majority of CRC models showed remarkably stable mutational and neoantigen profiles; however, those carrying defects in DNA repair genes continuously diversified. Rapidly evolving and evolutionary stable CRCs displayed characteristic genomic signatures and transcriptional profiles. Downregulation of molecules implicated in antigen presentation occurred selectively in highly mutated and rapidly evolving CRC. These results indicate that CRCs carrying alterations in DNA repair pathways display dynamic neoantigen patterns that fluctuate over time. We define CRC subsets characterized by slow and fast evolvability and link this phenotype to downregulation of antigen-presenting cellular mechanisms. Longitudinal monitoring of the neoantigen landscape could be relevant in the context of precision medicine." @default.
• W2954515247 created "2019-07-12" @default.
• W2954515247 creator A5003553378 @default.
• W2954515247 creator A5004556147 @default.
• W2954515247 creator A5009644242 @default.
• W2954515247 creator A5013358820 @default.
• W2954515247 creator A5024586369 @default.
• W2954515247 creator A5028593479 @default.
• W2954515247 creator A5031287599 @default.
• W2954515247 creator A5032586288 @default.
• W2954515247 creator A5049302590 @default.
• W2954515247 creator A5052141168 @default.
• W2954515247 creator A5055690483 @default.
• W2954515247 creator A5056194390 @default.
• W2954515247 creator A5057693519 @default.
• W2954515247 creator A5059864900 @default.
• W2954515247 creator A5060012110 @default.
• W2954515247 creator A5064011158 @default.
• W2954515247 creator A5078307539 @default.
• W2954515247 creator A5080555744 @default.
• W2954515247 creator A5084972491 @default.
• W2954515247 date "2019-06-28" @default.
• W2954515247 modified "2023-10-18" @default.
• W2954515247 title "Evolving neoantigen profiles in colorectal cancers with DNA repair defects" @default.
• W2954515247 cites W1496141235 @default.
• W2954515247 cites W1914351667 @default.
• W2954515247 cites W1934094702 @default.
• W2954515247 cites W1950829641 @default.
• W2954515247 cites W1999574084 @default.
• W2954515247 cites W2000064968 @default.
• W2954515247 cites W2004140222 @default.
• W2954515247 cites W2031324054 @default.
• W2954515247 cites W2033751993 @default.
• W2954515247 cites W2034353187 @default.
• W2954515247 cites W2042699075 @default.
• W2954515247 cites W2043398720 @default.
• W2954515247 cites W2059145105 @default.
• W2954515247 cites W2093297340 @default.
• W2954515247 cites W2102354469 @default.
• W2954515247 cites W2103441770 @default.
• W2954515247 cites W2108068107 @default.
• W2954515247 cites W2108234281 @default.
• W2954515247 cites W2121964616 @default.
• W2954515247 cites W2125789330 @default.
• W2954515247 cites W2126144698 @default.
• W2954515247 cites W2131408054 @default.
• W2954515247 cites W2131876608 @default.
• W2954515247 cites W2134471382 @default.
• W2954515247 cites W2137886330 @default.
• W2954515247 cites W2150056019 @default.
• W2954515247 cites W2152061559 @default.
• W2954515247 cites W2179438025 @default.
• W2954515247 cites W2180481128 @default.
• W2954515247 cites W2262414037 @default.
• W2954515247 cites W2271914738 @default.
• W2954515247 cites W2461427403 @default.
• W2954515247 cites W2462874491 @default.
• W2954515247 cites W2547187744 @default.
• W2954515247 cites W2549534074 @default.
• W2954515247 cites W2559382297 @default.
• W2954515247 cites W2606616407 @default.
• W2954515247 cites W2725858612 @default.
• W2954515247 cites W2737053924 @default.
• W2954515247 cites W2739132742 @default.
• W2954515247 cites W2767281692 @default.
• W2954515247 cites W2770647635 @default.
• W2954515247 cites W2791483720 @default.
• W2954515247 cites W2802455484 @default.
• W2954515247 cites W2808484886 @default.
• W2954515247 cites W2828180271 @default.
• W2954515247 cites W2886855629 @default.
• W2954515247 cites W2897815318 @default.
• W2954515247 cites W2901973709 @default.
• W2954515247 cites W2909679049 @default.
• W2954515247 cites W2912937988 @default.
• W2954515247 cites W2918086501 @default.
• W2954515247 cites W2922492752 @default.
• W2954515247 cites W4247053599 @default.
• W2954515247 doi "https://doi.org/10.1186/s13073-019-0654-6" @default.
• W2954515247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6599263" @default.
• W2954515247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31253177" @default.
• W2954515247 hasPublicationYear "2019" @default.
• W2954515247 type Work @default.
• W2954515247 sameAs 2954515247 @default.
• W2954515247 citedByCount "35" @default.
• W2954515247 countsByYear W29545152472019 @default.
• W2954515247 countsByYear W29545152472020 @default.
• W2954515247 countsByYear W29545152472021 @default.
• W2954515247 countsByYear W29545152472022 @default.
• W2954515247 countsByYear W29545152472023 @default.
• W2954515247 crossrefType "journal-article" @default.
• W2954515247 hasAuthorship W2954515247A5003553378 @default.
• W2954515247 hasAuthorship W2954515247A5004556147 @default.
• W2954515247 hasAuthorship W2954515247A5009644242 @default.
• W2954515247 hasAuthorship W2954515247A5013358820 @default.
• W2954515247 hasAuthorship W2954515247A5024586369 @default.
• W2954515247 hasAuthorship W2954515247A5028593479 @default.
• W2954515247 hasAuthorship W2954515247A5031287599 @default.
• W2954515247 hasAuthorship W2954515247A5032586288 @default.
• W2954515247 hasAuthorship W2954515247A5049302590 @default.

• next