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- W2954523357 abstract "Objective: TSR-042 is an investigational humanized antiprogrammed death (PD)–1 monoclonal antibody that binds with high affinity to the PD-1 receptor and effectively blocks interaction with the ligands PD-L1 and PD-L2. TSR-042 is being evaluated in patients with advanced solid tumors in the ongoing phase I/II GARNET trial (NCT02715284) (Sachdev JC et al. Ann Oncol. 2017(suppl 5):28:420;1185P). Here we present safety and efficacy data from the previously treated recurrent or advanced endometrial cancer (EC) cohorts, along with pharmacokinetics (PK) and receptor occupancy (RO) findings at the recommended phase II dose (RP2D)." @default.
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- W2954523357 date "2019-06-01" @default.
- W2954523357 modified "2023-10-16" @default.
- W2954523357 title "Preliminary safety, efficacy, and pharmacokinetic/pharmacodynamic characterization from GARNET, a phase I/II clinical trial of the anti–PD-1 monoclonal antibody, TSR-042, in patients with recurrent or advanced MSI-h and MSS endometrial cancer" @default.
- W2954523357 doi "https://doi.org/10.1016/j.ygyno.2019.04.044" @default.
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