FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2954526702> ?p ?o ?g. }

• W2954526702 abstract "Prostate androgen-regulated mucin-like protein 1 (PARM1) is a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response. A single nucleotide polymorphism in the coding region of PARM1 has been associated with competence of bovine embryos to develop to the blastocyst stage. Here we tested the importance of PARM1 for development by evaluating consequences of reducing PARM1 mRNA abundance on embryonic development and differentiation, gene expression and resistance to ER stress.Knockdown of PARM1 using an anti-PARM1 GapmeR did not affect competence of embryos to develop into blastocysts but decreased the number of trophectoderm (TE) cells in the blastocyst and tended to increase the number of cells in the blastocyst inner cell mass (ICM). Treatment of embryos with anti-PARM1 GapmeR affected expression of 4 and 3 of 90 genes evaluated at the compact-morula and blastocyst stage of development at days 5.5 and 7.5 after fertilization, respectively. In morulae, treatment increased expression of DAB2, INADL, and STAT3 and decreased expression of CCR2. At the blastocyst stage, knockdown of PARM1 increased expression of PECAM and TEAD4 and decreased expression of CCR7. The potential role of PARM1 in ER stress response was determined by evaluating effects of knockdown of PARM1 on development of embryos after exposure to heat shock or tunicamycin and on expression of ATF6, DDIT3 and EIF2AK3 at the compact morula and blastocyst stages. Both heat shock and tunicamycin reduced the percent of embryos becoming a blastocyst but response was unaffected by PARM1 knockdown. Similarly, there was no effect of knockdown on steady-state amounts of ATF6, DDIT3 or EIF2AK3.PARM1 participates in formation of TE and ICM cells in early embryonic development but there is no evidence for the role of PARM1 in the ER stress response." @default.
• W2954526702 created "2019-07-12" @default.
• W2954526702 creator A5028606515 @default.
• W2954526702 creator A5064982943 @default.
• W2954526702 creator A5067688757 @default.
• W2954526702 date "2019-07-05" @default.
• W2954526702 modified "2023-09-27" @default.
• W2954526702 title "Importance of prostate androgen-regulated mucin-like protein 1 in development of the bovine blastocyst" @default.
• W2954526702 cites W1694487551 @default.
• W2954526702 cites W1847920242 @default.
• W2954526702 cites W1958074369 @default.
• W2954526702 cites W1963680668 @default.
• W2954526702 cites W1970400867 @default.
• W2954526702 cites W1976889119 @default.
• W2954526702 cites W1979926360 @default.
• W2954526702 cites W1981290705 @default.
• W2954526702 cites W1986960611 @default.
• W2954526702 cites W1989361067 @default.
• W2954526702 cites W1990243394 @default.
• W2954526702 cites W1997119504 @default.
• W2954526702 cites W2012403379 @default.
• W2954526702 cites W2016260678 @default.
• W2954526702 cites W2029118376 @default.
• W2954526702 cites W2039350651 @default.
• W2954526702 cites W2049178111 @default.
• W2954526702 cites W2055221541 @default.
• W2954526702 cites W2062403136 @default.
• W2954526702 cites W2067117349 @default.
• W2954526702 cites W2079945043 @default.
• W2954526702 cites W2088639556 @default.
• W2954526702 cites W2092250528 @default.
• W2954526702 cites W2099681999 @default.
• W2954526702 cites W2101197781 @default.
• W2954526702 cites W2110482597 @default.
• W2954526702 cites W2125228455 @default.
• W2954526702 cites W2125720158 @default.
• W2954526702 cites W2138961762 @default.
• W2954526702 cites W2143468427 @default.
• W2954526702 cites W2145586371 @default.
• W2954526702 cites W2150780033 @default.
• W2954526702 cites W2161604602 @default.
• W2954526702 cites W2170728645 @default.
• W2954526702 cites W2509490855 @default.
• W2954526702 cites W2585912435 @default.
• W2954526702 cites W2610454042 @default.
• W2954526702 cites W2615491086 @default.
• W2954526702 cites W2734635583 @default.
• W2954526702 cites W2774096693 @default.
• W2954526702 cites W2792095728 @default.
• W2954526702 cites W2792547568 @default.
• W2954526702 cites W2800111904 @default.
• W2954526702 cites W2808685148 @default.
• W2954526702 cites W2901918794 @default.
• W2954526702 doi "https://doi.org/10.1186/s12861-019-0195-7" @default.
• W2954526702 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6612098" @default.
• W2954526702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31277570" @default.
• W2954526702 hasPublicationYear "2019" @default.
• W2954526702 type Work @default.
• W2954526702 sameAs 2954526702 @default.
• W2954526702 citedByCount "3" @default.
• W2954526702 countsByYear W29545267022020 @default.
• W2954526702 countsByYear W29545267022021 @default.
• W2954526702 crossrefType "journal-article" @default.
• W2954526702 hasAuthorship W2954526702A5028606515 @default.
• W2954526702 hasAuthorship W2954526702A5064982943 @default.
• W2954526702 hasAuthorship W2954526702A5067688757 @default.
• W2954526702 hasBestOaLocation W29545267021 @default.
• W2954526702 hasConcept C104317684 @default.
• W2954526702 hasConcept C139447449 @default.
• W2954526702 hasConcept C158617107 @default.
• W2954526702 hasConcept C159399396 @default.
• W2954526702 hasConcept C16685009 @default.
• W2954526702 hasConcept C173396325 @default.
• W2954526702 hasConcept C196843134 @default.
• W2954526702 hasConcept C2778177303 @default.
• W2954526702 hasConcept C54355233 @default.
• W2954526702 hasConcept C71924100 @default.
• W2954526702 hasConcept C86803240 @default.
• W2954526702 hasConcept C87073359 @default.
• W2954526702 hasConcept C95444343 @default.
• W2954526702 hasConceptScore W2954526702C104317684 @default.
• W2954526702 hasConceptScore W2954526702C139447449 @default.
• W2954526702 hasConceptScore W2954526702C158617107 @default.
• W2954526702 hasConceptScore W2954526702C159399396 @default.
• W2954526702 hasConceptScore W2954526702C16685009 @default.
• W2954526702 hasConceptScore W2954526702C173396325 @default.
• W2954526702 hasConceptScore W2954526702C196843134 @default.
• W2954526702 hasConceptScore W2954526702C2778177303 @default.
• W2954526702 hasConceptScore W2954526702C54355233 @default.
• W2954526702 hasConceptScore W2954526702C71924100 @default.
• W2954526702 hasConceptScore W2954526702C86803240 @default.
• W2954526702 hasConceptScore W2954526702C87073359 @default.
• W2954526702 hasConceptScore W2954526702C95444343 @default.
• W2954526702 hasIssue "1" @default.
• W2954526702 hasLocation W29545267021 @default.
• W2954526702 hasLocation W29545267022 @default.
• W2954526702 hasLocation W29545267023 @default.
• W2954526702 hasLocation W29545267024 @default.
• W2954526702 hasLocation W29545267025 @default.
• W2954526702 hasOpenAccess W2954526702 @default.

• next